A5004233738- Lung Cancer Diagnosis and Treatment
- Tracheal and airway disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lung Cancer Treatments and Mutations
- Asthma and respiratory diseases
- Airway Management and Intubation Techniques
- Respiratory Support and Mechanisms
- COVID-19 Clinical Research Studies
- Medical Imaging and Pathology Studies
- Vascular Anomalies and Treatments
- Cancer Immunotherapy and Biomarkers
- Respiratory and Cough-Related Research
- Otitis Media and Relapsing Polychondritis
- Pleural and Pulmonary Diseases
- Phonocardiography and Auscultation Techniques
- Trauma Management and Diagnosis
- Long-Term Effects of COVID-19
- Esophageal Cancer Research and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Voice and Speech Disorders
- Congenital Ear and Nasal Anomalies
- Esophageal and GI Pathology
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Ultrasound in Clinical Applications
St. Marianna University School of Medicine
2016-2025
Respiratory Clinical Trials
2018
Heidelberg University
2011
Kawasaki Hospital
2007
Japanese Red Cross Kumamoto Hospital
2004-2006
Self-Defense Forces Central Hospital
1999
Hiroshima Prefectural Hospital
1999
Hiroshima University
1997
City Hospital
1993
National Defense Medical College
1992
Background Conventional methods for lung cancer detection including computed tomography (CT) and bronchoscopy are expensive invasive. Thus, there is still a need an optimal technique. Methods The exhaled breath of 50 patients with histologically proven by bronchoscopic biopsy samples (32 adenocarcinomas, 10 squamous cell carcinomas, 8 small carcinomas), were analyzed using ion mobility spectrometry (IMS) compared 39 healthy volunteers. As secondary assessment, we adenocarcinoma without...
Abstract Introduction COVID‐19 pandemic led to significant reductions in influenza detection worldwide, fueling debates on whether truly ceased circulating communities. The number of cases decreased significantly Japan, raising concerns about the potential risk immunity population. Our single‐center study aimed investigate trends before and during Tokyo, Japan. Materials Methods This cross‐sectional included patients all ages who visited Tokyo Shinagawa Hospital between April 1, 2018, March...
Background: Genetic panel tests require sufficient tissue samples, and therefore, cannot always be performed. Although collecting cytological specimens is easier than collection, there are no validation studies on the diagnostic accuracy of lung cancer gene using cytology samples. Methods: Using an amplicon-based high-sensitivity next-generation sequencing test capable measuring eight druggable genes, we prospectively enrolled consecutive patients who underwent procedures. We evaluated...
<i>Background:</i> Narrow band imaging (NBI), which enhances blood vessels, is a new endoscopic technology for diagnosing malignancies, but it has not been investigated pleuroscopy. <i>Objectives:</i> To evaluate the efficacy of NBI applied to pleuroscopy detecting malignant lesions by assessing vascular patterns pleura. <i>Methods:</i> From May 2006 September 2008, 45 patients with undiagnosed pleural ef-fusion underwent using pleura-videoscope white...
Programmed cell death-1 (PD-1) immune checkpoint inhibitor antibody has proven to be effective in advanced non-small lung cancer (NSCLC) patients positive for programmed ligand-1 (PD-L1). However, there are currently no prospective studies evaluating PD-L1 expression small biopsy samples. To prospectively investigate the reliability of samples NSCLC, we included who underwent diagnostic by flexible bronchoscopy, computed tomography (CT) and ultra-sonography (US) guided core-needle determine...
Background Recent studies have revealed a reduction in the skeletal muscle area patients with advanced non‐small cell lung cancer ( NSCLC ) after chemotherapy. EGFR and ALK tyrosine kinase inhibitor TKI )‐based therapies are less cytotoxic than chemotherapy, but differences mass between receiving chemotherapy not yet been reported. Methods Data of pathologically proven were reviewed, chest computed tomography and/or positron emission tomography‐computed images obtained from J anuary 2012 to...
Abstract Airway involvement in relapsing polychondritis (RP) can be debilitating and life threatening, often requiring interventional procedures. If standard therapies including systemic corticosteroid immunosuppressive agents are ineffective, airway stenting is required. Recently, biologics have been reported to effective for RP, the early administration of may avoid stenting. To evaluate survival rates treatment approaches, medical records RP patients with were reviewed. These cases...
While smoking has consistently been shown to be related increased risk of colorectal adenomas, few studies have addressed the association between and site‐specific adenomas. The reported alcohol use adenomas inconsistent. We evaluated risks at proximal colon, distal rectum in relation cigarette use, their interaction. Subjects were 754 cases with histologically proven 1547 controls normal colonoscopy among male officials Self‐Defense Forces (SDF) undergoing total two SDF hospitals....
Lateral airway pressure can provide valuable physiological information during bronchoscopy.To evaluate tracheal obstruction intervention.To prospectively measure lateral bronchoscopy using a double-lumen catheter in 15 healthy subjects and 30 patients with obstruction. Pressure difference was used to the site of maximal The angle between recordings on either side stenosis measured simultaneously (pressure-pressure curves) assess degree obstruction.In experimental study, pressure-pressure...
<h3>BACKGROUND:</h3> Spirometry is used to physiologically assess patients with central airway obstruction (CAO) before and after interventional bronchoscopy, but not always feasible in these patients, does localize the anatomic site of obstruction, may correlate patient9s functional impairment. Impulse oscillometry overcome limitations. We assessed correlations between impulse measurements, symptoms, type narrowing, whether parameters can discriminate fixed dynamic CAO. <h3>METHODS:</h3>...
There are few prospective reports of transbronchial lung cryobiopsy (TBLC) for malignant tumors in combination with forceps biopsy. We investigated the clinical parameters which TBLC is superior to This a cohort study analyse efficacy suspected malignancy. was performed after brushing cytology and biopsy, diagnostic yield TBLC, cytology, biopsy were examined. Adverse events defined as those requiring additional procedures. Next-generation sequencing (NGS) analysis each case non-small cell...
Transbronchial lung biopsy is an indispensable method for the diagnosis of peripheral lesions; however, diagnostic yield still remains unsatisfactory. Endobronchial ultrasound with guide sheath (EBUS-GS) excellent decision points and has contributed to improvements in yield, but choosing proper bronchus depends on individual ability each bronchoscopist. To clarify usefulness virtual bronchoscopic navigation system (VBN), we evaluated time required determine target lesion. Fifty-seven cases...
Next-generation sequencing (NGS) enables the diagnosis of large numbers gene aberrations during one examination, and precision medicine has been developed for patients with advanced non-small cell lung cancer (NSCLC). However, peripheral lesions account majority cancers, especially adenocarcinoma. In these cases, it is difficult to obtain tissue samples which contain sufficient tumor cells by transbronchial biopsy (TBB) forceps. Even when target are quite small, bronchial brushing can enough...
Abstract Corticosteroids use in coronavirus disease 2019 (COVID-19) is controversial, especially mild to severe patients who do not require invasive/noninvasive ventilation. Moreover, many factors remain unclear regarding the appropriate of corticosteroids for COVID-19. In this context, multicenter, retrospective, propensity score–matched study was launched evaluate efficacy systemic corticosteroid administration hospitalized with COVID-19 ranging degree severity from critically-ill disease....
In western Yokohama, our hospital and primary care clinics manage adults with asthma via a coordinated system. We investigated the changes in fractional expired nitric oxide (FeNO), forced expiratory volume 1 second (FEV
The purpose of this study was to elucidate the mechanism underlying effects adipose tissue-derived stem/stromal cell (ASC) transplantation on porcine pancreatic elastase-induced emphysema.ASCs (2.5 × 10(6)) were transplanted into elastase (250 U/kg)-treated rats, after which gas exchange and growth factor/cytokine levels in lung tissue determined.ASC restored pulmonary function (arterial oxygen tension alveolar-arterial difference) almost that normal animals. Enlargement alveolar airspaces...