A5073708168- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- Myasthenia Gravis and Thymoma
- Antifungal resistance and susceptibility
- Pulmonary Hypertension Research and Treatments
- Tracheal and airway disorders
- Fungal Infections and Studies
- Infectious Diseases and Mycology
- Cancer Diagnosis and Treatment
- IgG4-Related and Inflammatory Diseases
- Inhalation and Respiratory Drug Delivery
- Peripheral Neuropathies and Disorders
- Congenital Diaphragmatic Hernia Studies
- Pericarditis and Cardiac Tamponade
- Long-Term Effects of COVID-19
- Pleural and Pulmonary Diseases
- COVID-19 Clinical Research Studies
- Metastasis and carcinoma case studies
- Sarcoidosis and Beryllium Toxicity Research
- Occupational and environmental lung diseases
- Neonatal Respiratory Health Research
- Toxoplasma gondii Research Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Pneumothorax, Barotrauma, Emphysema
- Soft tissue tumor case studies
Toho University Omori Medical Center
2009-2018
Toho University
2009-2018
Abstract Corticosteroids use in coronavirus disease 2019 (COVID-19) is controversial, especially mild to severe patients who do not require invasive/noninvasive ventilation. Moreover, many factors remain unclear regarding the appropriate of corticosteroids for COVID-19. In this context, multicenter, retrospective, propensity score–matched study was launched evaluate efficacy systemic corticosteroid administration hospitalized with COVID-19 ranging degree severity from critically-ill disease....
The aim of this study was to investigate the effect outpatient pulmonary rehabilitation (PR) program and use 6-min walk distance (6MWD), expressed as a percentage predicted value (%6MWD), quantify response PR in elderly patients with interstitial lung disease (ILD).This prospective, nonrandomized controlled study. Forty eligible stable ILD (≥65 y old) were advised attend an for 3 mo. Thirteen completed formed group. Ten who did not evaluated after mo control Patients group underwent...
Chronic pulmonary aspergillosis (CPA) has been accepted the criteria for diagnosis of Aspergillus infection. Whereas, either pathophysiology or signs CPA remains still controversial.In this study, we histopathologically investigated 25 specimens CPA, surgically resected.21 (84 %) that comprised male. There were 21 cases with mild impairment immune system and/or a scar mostly due to old tuberculosis. is tendency negative correlation between peripheral blood white cell numbers and value level...
Background Little has been reported on the feasibility of xenon-enhanced dual-energy computed tomography (Xe-DECT) in visual and quantitative analysis combined pulmonary fibrosis emphysema (CPFE). Objectives We compared CPFE with idiopathic (IPF) chronic obstructive disease (COPD), as well correlation parameters function tests (PFTs). Methods Studied 3 groups were 25 patients CPFE, IPF without (IPF alone), 30 COPD. Xe-DECT patients' entire thorax was taken from apex to base after a patient's...
Antiphospholipid syndrome (APS) is clinically characterized by arterial or venous thrombosis; however, non-thromboembolic lung manifestations, such as diffuse alveolar hemorrhage (DAH), have also been previously reported. DAH relatively common in APS patients with systemic lupus erythematosus, although it rare primary APS. We encountered a 78-year-old man who presented hemoptysis and dyspnea. Chest CT showed ground-glass opacity pulmonary thromboembolism. He was successfully treated...
We report a case of miliary tuberculosis associated with chronic neutrophilic leukemia (CNL). A 70-year-old woman was referred to our hospital complaining 1-month history persistent fever and anorexia. Chest abdominal computed tomography images revealed diffuse small nodular lesions in the bilateral lung fields extreme splenomegaly. Sputum cultures isolated Mycobacterium tuberculosis. After anti-tuberculous therapy for 1 year, patient underwent splenectomy massive splenomegaly progressive...
Immunoglobulin G4 (IgG4)-related lung diseases can occur in patients with autoimmune pancreatitis (AIP). However, the causal relationship between AIP and acquired hemophilia A (AH) is unknown. We herein report first case of AH associated IgG4-related disease that developed a patient AIP. 65-year-old asymptomatic man history sclerosing cholangitis diagnosed at age 57 was admitted to our hospital due an abnormal reticulonodular shadow on chest X-ray. An examination biopsy specimens revealed...
A 73-year-old male metalworker was admitted to our hospital with a 3-year history of progressive dry cough. Chest high-resolution computed tomography revealed emphysematous changes and reticular lesions, which is referred as combined pulmonary fibrosis emphysema (CPFE). Surgical lung biopsy specimens unclassified interstitial pneumonia, including nonspecific pneumonia pattern usual pattern. Two years after his first admission he developed rapid renal dysfunction an elevated level...
Chronic pulmonary aspergillosis (CPA) is a refractory disorder that needs long-term antifungal treatment and occasionally results in fatal respiratory failure hemoptysis. However, the pathological features of have not been thoroughly delineated. Thirty cases were therefore analyzed clinically histologically to elucidate pathophysiology CPA. The subjects comprised 14 individuals who underwent surgical removal 16 patients died. No subject exhibited severely immunocompromised state. main...
Idiopathic pulmonary hemosiderosis is characterized by repeated alveolar hemorrhaging. We herein report a 52-year-old Japanese woman who had shortness of breath, diffuse small nodules, thin-walled cysts, and bronchiolectasis. A surgical lung biopsy revealed peribronchial hemosiderosis, centrilobular emphysema, fragile elastic fibers the septa vessels. She ultimately underwent living-donor transplantation five years after first visit.
A 30-year-old male smoker with congenital amblyopia and oculocutaneous albinism was admitted to our hospital complaining of progressive dyspnea on exertion. Chest computed tomography images revealed diffuse reticular opacities honeycombing in the bilateral lower lobes sparing subpleural region along emphysema predominantly upper lobes. Lung biopsy specimens showed a mixture usual interstitial pneumonia non-specific pattern emphysema. Of note, cuboidal epithelial cells foamy cytoplasm...
Trastuzumab deruxtecan (T-DXd) frequently induces interstitial lung disease (ILD) more than other anti-human epidermal growth factor receptor 2 therapies. We diagnosed two cases of ILD induced by T-DXd in patients with advanced breast cancer. The first case is that a 57-year-old Japanese woman who complained dyspnoea and fever after 4 cycles T-DXd. Chest computed tomography (CT) showed diffuse consolidation reticular shadow. second was 72-year-old 3 CT shadow predominantly the left lung....
A 30-year-old man was admitted to Toho University Omori Medical Center for assessment of right chest pain and fever. Chest computed tomography (CT) revealed an anterior mediastinal tumor sized 11.0×6.0×5.0 cm, with pleural effusion. The laboratory analysis elevated white blood cell count (11,000/µl), C-reactive protein (4.1 mg/dl) cytokeratin fragment (CYFRA; 12.7 ng/ml; normal, <2 ng/ml). level CYFRA in the effusion also markedly (143 On first day after admission (6 days initial CT), there...
We report a case of pulmonary Mycobacterium abscessus (M. abscessus) infection with destructive growth in the entire right lung. The patient was 56-year-old woman who had tuberculosis at age 40 and been diagnosed as having 4 years prior to admission our hospital. Although various antibiotics were administered, persistent fever, hemoptysis weight loss developed. After undergoing pneumonectomy, her clinical symptoms improved dramatically sputum excretions M. ceased. No relapse disease has...
Abstract Background : Corticosteroids use in coronavirus disease 2019 (COVID-19) is controversial, especially mild to severe patients who do not require invasive/noninvasive ventilation. Moreover, many factors remain unclear regarding the appropriate of corticosteroids for COVID-19. In this context, multicenter, retrospective, propensity score–matched study was launched evaluate efficacy systemic corticosteroid administration hospitalized with COVID-19 ranging degree severity from...
Good's syndrome is associated with thymoma and acquired immunodeficiency. A 54-year-old man visited our hospital a complaint of cough. Chest imaging revealed diffuse nodular shadows anterior mediastinal mass. Hypogammaglobulinemia decreased B lymphocyte count were found by laboratory evaluation. The lung nodules markedly regressed after immunoglobulin therapy. mass remaining nodule surgically resected diagnosed as type AB necrotizing epithelioid granuloma T lymphocyte-dominant alveolitis,...
Cytomegalovirus infection is typically asymptomatic in immunocompetent individuals. A 26-year-old woman was admitted to our hospital with a fever and breathlessness. Chest computed tomography (CT) revealed bilateral diffuse reticulation nodules. Laboratory investigations showed atypical lymphocytosis increased transaminases. She treated corticosteroid pulse therapy because of acute lung injury, her clinical condition improved. Based on the presence antibodies, antigen, polymerase chain...
Abstract A 28‐year‐old woman with a history of treatment low‐dose oestrogen–progestin (LEP) formulation presented to our hospital due right chest pain. She had just been discharged from another for pneumonia and pleurisy which improved antibiotics. Contrast‐enhanced computed tomography (CT) revealed bilateral pulmonary emboli corresponding the peripheral consolidations. The indicated that consolidation was infarction (PI). No aetiological factors were identified except LEP therapy. Although...
背景．肺癌回腸転移は生前診断されることは稀である．症例．症例1は61歳男性．非小細胞癌の術後再発で，化学療法中に急性腹症を発症した．胸部X線，腹部CTにて腹腔内にfree airを認め，消化管穿孔と診断した．緊急手術を行ったところ，回腸に腫瘍を認め，肺癌の回腸転移による消化管穿孔と診断した．術後3日目に敗血症で死亡した．症例2は72歳男性．非小細胞癌（cT3N2M1，stage IV）で，化学療法施行中に急性腹症と大量下血を認めた．保存的治療では症状が改善せず，開腹手術を行ったところ回腸に腫瘍を認め，肺癌回腸転移からの出血と診断した．術後1カ月で癌死した．結論．今後，急性腹症を生じ緊急処置を要する可能性のある小腸転移の早期発見を目的としたFDG-PETやPET-CT検査によるスクリーニング，さらに消化管に集積を認めた症例には，積極的な消化管内視鏡検査による診断が必要であると考えられた．