Hirofumi Kamata
A5026865435- COVID-19 Clinical Research Studies
- Mycobacterium research and diagnosis
- Long-Term Effects of COVID-19
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Tuberculosis Research and Epidemiology
- COVID-19 and healthcare impacts
- SARS-CoV-2 and COVID-19 Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Infectious Diseases and Mycology
- Immune Response and Inflammation
- Respiratory Support and Mechanisms
- Pneumocystis jirovecii pneumonia detection and treatment
- Dysphagia Assessment and Management
- SARS-CoV-2 detection and testing
- Lung Cancer Treatments and Mutations
- Pneumonia and Respiratory Infections
- Pleural and Pulmonary Diseases
- Eosinophilic Disorders and Syndromes
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer-related molecular mechanisms research
- Inflammatory Myopathies and Dermatomyositis
- Immune Cell Function and Interaction
- Immune cells in cancer
- Erythrocyte Function and Pathophysiology
Keio University
2015-2025
Pulmonary Associates
2009-2023
Tokyo Medical and Dental University
2022
National Hospital Organization
2022
Tokyo Medical Center
2022
Kyoto University
2022
Nihon University
2021
Saiseikai Central Hospital
2011-2017
Creative Commons
2017
Saiseikai Utsunomiya hospital
2013
Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge1-5. Here we conducted a genome-wide association study (GWAS) involving 2,393 cases of in cohort Japanese individuals collected during initial waves pandemic, with 3,289 unaffected controls. We identified variant on chromosome 5 at 5q35 (rs60200309-A), close to dedicator cytokinesis 2 gene (DOCK2), which was associated patients less than 65 years age. This risk allele prevalent East Asian but rare...
We aimed to elucidate differences in the characteristics of patients with coronavirus disease 2019 (COVID-19) requiring hospitalization Japan, by COVID-19 waves, from conventional strains Delta variant.We used secondary data a database and performed retrospective cohort study that included 3261 aged ≥ 18 years enrolled 78 hospitals participated Japan Task Force between February 2020 September 2021.Patients hospitalized during second (mean age, 53.2 [standard deviation {SD}, ± 18.9]) fifth...
Mechanisms underpinning the dysfunctional immune response in severe acute respiratory syndrome coronavirus 2 infection are elusive. We analyzed single-cell transcriptomes and T B cell receptors (BCR) of >895,000 peripheral blood mononuclear cells from 73 disease 2019 (COVID-19) patients 75 healthy controls Japanese ancestry with host genetic data. COVID-19 showed a low fraction nonclassical monocytes (ncMono). report downregulated transitions classical to ncMono reduced CXCL10 expression...
Predictive models for determining coronavirus disease 2019 (COVID-19) severity have been established; however, the complexity of interactions among factors limits use conventional statistical methods. This study aimed to establish a simple and accurate predictive model COVID-19 using an explainable machine learning approach. A total 3,301 patients ≥ 18 years diagnosed with between February 2020 October 2022 were included. The discovery cohort comprised whose onset fell before 1, (N = 1,023),...
<i>Background:</i> CC chemokines play important roles in the pathogenesis of interstitial lung diseases. Elevated chemokine levels have been observed bronchoalveolar lavage (BAL) fluid patients with idiopathic pulmonary fibrosis (IPF). <i>Objectives:</i>We aimed to examine whether four chemokines, i.e. monocyte chemoattractant protein-1 (MCP-1/CCL2), macrophage inflammatory protein-1α (MIP-1α/CCL3), thymus- and activation-regulated (TARC/CCL17), macrophage-derived...
Although arachidonic acid cascade has been shown to be involved in sepsis, little is known about the role of PGD(2) and its newly found receptor, chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2), septic response. Severe sepsis associated with failure neutrophil migration. To investigate whether CRTH2 influences recruitment lethality during was induced by cecal ligation puncture (CLP) surgery mice. knockout (CRTH2(-/-)) mice were highly resistant CLP-induced which...
The coronavirus disease (COVID-19) pandemic is having a devastating effect worldwide. Host genome differences between populations may influence the severity of COVID-19. Japan COVID-19 Task Force conducting host analysis hospitalized patients with from more than 70 institutions nationwide in Japan. This report describes clinical characteristics enrolled to date. median (interquartile range) age 1674 included was 59 (45-71) years, and half (66.2%) were male. Less (41.2%) had severe disease....
Abstract Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious that has caused millions of deaths, where comprehensive understanding mechanisms still unestablished. In particular, studies gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on thorough analysis whole blood RNA-seq data from 465 genotyped samples the Japan Task Force, including 359 severe 106 non-severe cases. We discover 1169 putative causal...
Abstract Background Respiratory symptoms are associated with coronavirus disease 2019 (COVID-19) outcomes. However, the impacts of upper and lower respiratory on COVID-19 outcomes in same population have not been compared. The objective this study was to characterize compare their hospitalized patients. Methods This a multicenter, retrospective cohort study; database from Japan Task Force used. A total 3314 patients were included study, data collected. participants classified according...
COVID-19 was severe in the Delta variant-dominated epidemic wave (fifth wave) Japan. The clinical characteristics and effectiveness of vaccination are not fully understood Omicron (sixth seventh waves), especially hospitalized patients. We investigated relationship between disease severity Omicron-dominated compared these waves.The nationwide database (Japan Task Force) used to compare critical outcomes patients with (fifth, N = 735) vs waves (sixth, 495; seventh, 128).Patients sixth had a...
Although cases of respiratory bacterial infections associated with coronavirus disease 2019 (COVID-19) have often been reported, their impact on the clinical course remains unclear. Herein, we evaluated and analyzed complication rates infections, causative organisms, patient backgrounds, outcome in Japanese patients COVID-19.We performed a retrospective cohort study that included inpatients COVID-19 from multiple centers participating Japan Taskforce (April 2020 to May 2021) obtained...
Macrolides are used to treat various inflammatory diseases owing their immunomodulatory properties; however, little is known about precise mechanism of action. In this study, we investigated the functional significance expansion myeloid-derived suppressor cell (MDSC)-like CD11b+Gr-1+ cells in response macrolide antibiotic clarithromycin (CAM) mouse models shock and post-influenza pneumococcal pneumonia as well humans. Intraperitoneal administration CAM markedly expanded splenic lung...
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With the recent increasing use of nanoparticles, there is concern that they may become an environmental risk factor as airborne particles. However, impact these particles on susceptible subjects with predisposing lung disease have not been sufficiently elucidated. In present study, we investigated effects nanoparticles pulmonary inflammatory and fibrotic changes induced by intratracheal bleomycin (BLM) challenge in mice. Mice were intratracheally administered either vehicle, 14-nm carbon...
In bronchiectasis patients, chronic Pseudomonas aeruginosa (PA) infection has been associated with worse health-related quality of life (HRQL), but little is known about Mycobacterium avium complex lung disease (MACLD) patients in this context. This study aimed to evaluate HRQL and investigate the impact PA MACLD patients. cross-sectional was conducted using Registry Prospective Cohort Study including The 36-item Short-Form health survey (SF-36) St. George’s Respiratory Questionnaire (SGRQ)...
This study aimed to identify the relationship between abnormal serum uric acid levels or a history of hyperuricemia and COVID-19 severity in Japanese population.We included 1523 patients enrolled Japan Task Force cohort February 2020 May 2021. We compared clinical characteristics, including co-morbidities, laboratory findings, outcomes, particularly invasive mechanical ventilation (IMV), among with without hyperuricemia.Patients high were older had higher body weight mass index than those...
Abstract Background Obesity is reported to be a risk factor for severe disease in patients with coronavirus 2019 (COVID-19). However, there are no specific reports on the of according body mass index (BMI) Japan. Thus, this study aimed investigate effect obesity stratified by BMI severity COVID-19 general Japanese population. Methods From February 2020 May 2021, 1 837 aged ≥18 years were enrolled Japan Task Force. Patients known and analyzed. Severity was defined as critical if patient...