A5065833452- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- COVID-19 Clinical Research Studies
- Sarcoidosis and Beryllium Toxicity Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lung Cancer Research Studies
- Pneumonia and Respiratory Infections
- Occupational and environmental lung diseases
- Medical Imaging and Pathology Studies
- SARS-CoV-2 and COVID-19 Research
- Intensive Care Unit Cognitive Disorders
- Inflammatory Myopathies and Dermatomyositis
- Nosocomial Infections in ICU
- Long-Term Effects of COVID-19
- Diabetes and associated disorders
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Diagnosis and Treatment
- Neonatal Respiratory Health Research
- interferon and immune responses
- Cardiac Valve Diseases and Treatments
- Thermal Regulation in Medicine
- Cancer Diagnosis and Treatment
- Single-cell and spatial transcriptomics
Saiseikai Kumamoto Hospital
2016-2025
Social Welfare Organization Saiseikai Imperial Gift Foundation
2016-2025
Santen (Japan)
2024
Kyoto University
2024
Scientific Research WorkS Peer Support Group
2024
Kyoto Min-iren Asukai Hospital
2024
Osaka University
2015
Kumamoto University
2005
Akita Red Cross Hospital
1996
Seiwa Hospital
1991
To examine whether the extent of fibroproliferative changes on high-resolution CT (HRCT) scan influences prognosis, ventilator dependency and associated outcomes in patients with early acute respiratory distress syndrome (ARDS).
Acute exacerbation (AE) of idiopathic pulmonary fibrosis (IPF) is a fatal condition without an established pharmaceutical treatment. Most patients are treated with high-dose corticosteroids and broad-spectrum antibiotics. Azithromycin macrolide immunomodulatory activity may be beneficial for treatment acute lung injury. The objective this study was to determine the effect azithromycin on survival AE IPF.We evaluated 85 consecutive hospitalized in our department IPF from April 2005 August...
ABSTRACT Dendritic cells (DCs) are antigen-presenting with the ability to induce primary immune responses necessary in innate immunity and adaptive immunity. Osteopontin (OPN) is a secreted acidic phosphoprotein containing an arginine-glycine-aspartate sequence has been suggested play important role early cellular responses. The interaction between DCs OPN not clarified. We hypothesized that there OPN, which indispensable extracellular matrix component Human monocyte-derived synthesized...
<b><i>Background:</i></b> Acute exacerbation of chronic fibrosing interstitial pneumonia (AE-CFIP) is an often fatal condition with no established treatment. Recently, macrolides were found to be beneficial in cases acute lung injury. <b><i>Objectives:</i></b> To examine the clinical effectiveness and safety intravenous azithromycin patients hospitalized for AE-CFIP. <b><i>Methods:</i></b> A prospective, open-label study...
Although cases of respiratory bacterial infections associated with coronavirus disease 2019 (COVID-19) have often been reported, their impact on the clinical course remains unclear. Herein, we evaluated and analyzed complication rates infections, causative organisms, patient backgrounds, outcome in Japanese patients COVID-19.We performed a retrospective cohort study that included inpatients COVID-19 from multiple centers participating Japan Taskforce (April 2020 to May 2021) obtained...
Acute respiratory distress syndrome is a life-threatening form of failure without an established pharmacological treatment. Recently, macrolides have been found to be beneficial in cases acute lung injury, but evidence limited.This single-centre retrospective cohort evaluation hospitalized patients with sepsis-associated aimed assess the impact azithromycin on clinical outcomes by using propensity score analysis. All data were collected prospectively as part ongoing research high-resolution...
The efficacy of corticosteroid use in acute respiratory distress syndrome (ARDS) remains controversial. Generally, short-term high-dose therapy is considered to be ineffective ARDS. On the other hand, low-dose, long-term corticosteroids has been reported effective since they provide continued inhibition systemic inflammatory response (SIRS) that accompanies Thus far, no reports have published on initiating treatment with a regimen tapering.We conducted retrospective observational study...
Abstract Background The use of baseline tumor burden (TB) as a prognostic factor for non‐small cell lung cancer (NSCLC) patients treated with immune checkpoint inhibitors (ICIs) and associations between TB other biomarkers remain unclear. In this study, we investigated the association survival in NSCLC ICIs comparison biomarkers. Methods We retrospectively evaluated 83 administered February 2016 December 2018. was measured sum unidimensional diameters up to five target lesions. Results...
Here, we present real-world data on the incidence and risk factors of acute exacerbation (AE) in patients with chronic fibrotic interstitial pneumonia (CFIP) treated antifibrotic agents, which has been previously poorly documented.We retrospectively examined clinical characteristics, AE a cohort 100 CFIP (n = 75, idiopathic pulmonary fibrosis [IPF]; n 25, other conditions), all whom received agents setting.The median follow-up was 17.4 months (interquartile range [IQR], 6.6 to 26.7 months)....
Abstract Background Although corticosteroid therapy with dose tapering is the most commonly used treatment for acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF), there no consensus on regimen. This study aimed to investigate association between early and in-hospital mortality in patients AE-IPF. Methods In this retrospective cohort study, we analyzed data a from eight Japanese tertiary care hospitals routinely collected administrative 185 hospitals. Patients AE-IPF were classified...
Although acute respiratory distress syndrome (ARDS) reportedly shows various clinical phenotypes with different risk and prognostic factors, few studies have assessed the features prognosis of pulmonary extrapulmonary ARDS. The aim present study was to investigate differences between ARDS.In total, 200 patients who met Berlin criteria were diagnosed ARDS October 2004 September 2017 included. We classified into groups. Both groups for 60-day mortality, duration ventilation, other...
Objectives To report the clinical features and prognosis of drug-associatedacute respiratory distress syndrome (ARDS). Design A retrospective analysis data collected during a prospective cohort study. Setting Intensive care unit in teaching hospital. Participants total 197 Japanese patients with ARDS diagnosed by Berlin definition who were admitted to Division Respiratory Medicine from October 2004 December 2015 enrolled study classified as two groups according their causes: drug-associated...
Abstract Drugs can cause acute respiratory distress syndrome (ARDS). However, there is no established clinical prediction rule for drug-associated ARDS (DARDS). We aimed to develop and validate a scoring system DARDS prediction. analysed data collected from prospective, single-centre, cohort study that included patients. The diagnosis was based on the American-European Consensus Conference or Berlin definition. Drug-associated lung injury (DALI) defined as previous exposure drugs which ALI...
Recent studies have suggested that an increased peripheral monocyte count predicts a poor outcome in fibrosing interstitial lung disease (ILD). However, the association between and acute exacerbations (AEs) of ILD remains to be elucidated. Our retrospective cohort study aimed assess impact on AEs ILD. We analyzed electronic medical records 122 consecutive patients with no prior history AE, who were treated anti-fibrotic agents from August 2015 December 2018. determined their counts at agent...
We aimed to develop algorithms identify patients with acute exacerbation of interstitial pneumonia and lung diseases using Japanese administrative data.
Alectinib, a second-generation anaplastic lymphoma kinase (ALK) inhibitor, is key drug for ALK rearranged lung adenocarcinoma. Interstitial disease (ILD) an important adverse effect of alectinib, which generally requires termination treatment. However, we treated two patients with drug-induced ILD who continued to receive alectinib. Patient 1 was 57-year-old male ALK-rearranged Stage IV adenocarcinoma administered alectinib as first-line therapy. Computed tomography (CT) detected...
Abstract Background Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‐TKIs) are used to treat patients with non‐small cell lung cancer (NSCLC) and EGFR driver mutations. Although some discontinued these treatments because of adverse events, it is unclear whether switching EGFR‐TKI events provides a benefit. Methods This retrospective study evaluated data from 22 mutation‐positive NSCLC who received at least two EGFR‐TKIs that were switched (March 2011 September 2017)....
Hermansky-Pudlak syndrome (HPS) is an autosomal recessive disorder characterized by oculocutaneous albinism, bleeding tendency, and lysosomal accumulation of ceroid-like material, with occasional development interstitial pneumonia (IP). Nine genetically distinct subtypes HPS are known in humans; IP develops primarily types 1 4. Most reported cases type 1, there no published reports 4 Japanese individuals. A 58-year-old man congenital albinism progressive dyspnea for month was admitted to our...