A5033342098- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lung Cancer Treatments and Mutations
- Medical Imaging and Pathology Studies
- Sarcoidosis and Beryllium Toxicity Research
- Respiratory Support and Mechanisms
- Eosinophilic Disorders and Syndromes
- Lung Cancer Research Studies
- Respiratory and Cough-Related Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Occupational and environmental lung diseases
- Cancer Immunotherapy and Biomarkers
- Inhalation and Respiratory Drug Delivery
- Pneumonia and Respiratory Infections
- Pulmonary Hypertension Research and Treatments
- Cardiac tumors and thrombi
- Sepsis Diagnosis and Treatment
- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Inflammatory Myopathies and Dermatomyositis
- Antifungal resistance and susceptibility
- Nosocomial Infections in ICU
- Tracheal and airway disorders
- Neuroendocrine Tumor Research Advances
- Peptidase Inhibition and Analysis
Kumamoto University
2014-2025
Kumamoto University Hospital
2015-2024
Toho University
2021
Toho University Omori Medical Center
2021
University of Indonesia
2013
Kariya Toyota General Hospital
2013
Shinko Hospital
2013
Fujita Health University
2013
National Hospital
2008
Harvard University Press
2003
Circulating levels of KL-6, a high MW glycoprotein (MUC1 mucin), are elevated in majority patients with number interstitial lung diseases, including idiopathic pulmonary fibrosis (IPF). However, KL-6 vary from patient to patient. The aim the present study was determine whether serum level at time diagnosis predicts prognosis IPF.The relationship between clinical variables and 27 IPF were analysed retrospectively. made by histological examination (n = 16) or on findings high-resolution CT...
It has previously been reported that the expression of monocyte chemoattractant protein-1 (MCP-1) in lung tissues patients with idiopathic pulmonary fibrosis (IPF) was different from other interstitial diseases (ILDs). The aim this study to determine whether difference reflects amount MCP-1 bronchoalveolar lavage fluid (BALF) or serum ILD, and such a correlation, if it exists, is clinically useful. concentrations BALF sera were evaluated 86 ILDs including IPF, acute pneumonia, pneumonia...
To examine whether the extent of fibroproliferative changes on high-resolution CT (HRCT) scan influences prognosis, ventilator dependency and associated outcomes in patients with early acute respiratory distress syndrome (ARDS).
ABSTRACT Dendritic cells (DCs) are antigen-presenting with the ability to induce primary immune responses necessary in innate immunity and adaptive immunity. Osteopontin (OPN) is a secreted acidic phosphoprotein containing an arginine-glycine-aspartate sequence has been suggested play important role early cellular responses. The interaction between DCs OPN not clarified. We hypothesized that there OPN, which indispensable extracellular matrix component Human monocyte-derived synthesized...
Introduction Tattoo sarcoidosis is characterized by a granulomatous reaction localized to the tattoo site and typical systemic symptoms of sarcoidosis. Herein, we report case patient diagnosed with Case A 28-year-old man presented subcutaneous nodules at two sites, bilateral hilar mediastinal lymphadenopathy, multiple micronodules predominantly in upper lobes both lungs, elevated serum angiotensin-converting enzyme soluble interleukin-2 receptor levels, hypercalcemia, renal dysfunction. Skin...
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Acute exacerbation of interstitial lung disease (AE-ILD) is the most serious complication in cancer patients with pre-existing ILD receiving chemotherapy. The role vascular endothelial growth factor (VEGF) pathogenesis AE-ILD conflicting. influence bevacizumab (Bev), a monoclonal antibody against VEGF, on remains unclear. We examined effect Bev reducing risk non-squamous non-small cell (NSCLC) analysed incidence and outcomes 48 advanced NSCLC who received first-line chemotherapy (Bev group,...
Abstract Introduction The impact of immune checkpoint blockade on immunity in cancer patients is not completely elucidated due to the complexity network. Recent studies have revealed a significant role programed cell death‐ligand 2 (PD‐L2) negatively controlling production CD4+ T helper type (Th2) cytokines and airway hypersensitiveness, suggesting hypo‐responsive Th2 cells via PD‐1/PD‐L2 inhibitory pathway lung could be reawaken by PD‐1 therapy. Methods We describe first report acute...
Journal Article Asymptomatic carriage of Pneumocystis jiroveci in elderly patients with rheumatoid arthritis Japan: a possible association between colonization and development pneumonia during low-dose MTX therapy Get access Shunsuke Mori, Mori Clinical Research Center for Rheumatic Disease Department Rheumatology, Kumamoto Saishunsou National Hospital, 2659 Suya, Kohshi, 861-1196, Japan Correspondence to: e-mail: moris@saisyunsou1.hosp.go.jp Search other works by this author on: Oxford...
Serum levels of pneumocyte biomarkers KL-6 and surfactant protein D (SP-D) are useful diagnostic markers for interstitial lung diseases. However, associations serum SP-D with radiologic findings in nonspecific pneumonia (NSIP) remain unclear.To determine whether reflect fibrotic and/or inflammatory processes NSIP, we investigated the correlation between high-resolution computed tomography (HRCT) levels.Serum were measured 21 patients biopsy-confirmed NSIP. The radiographic extent 6 HRCT...
We present 3 cases of rapidly progressive interstitial pneumonia (RPIP) associated with clinically amyopathic dermatomyositis (C-ADM) that were treated two courses direct hemoperfusion polymyxin B-immobilized fiber column (PMX-DHP). Despite initial treatment high-dose corticosteroids, pulsed cyclophosphamide, and cyclosporine, the lung disease hypoxemia deteriorated in all patients. After PMX-DHP treatment, PaO2/FiO2 ratio serum LDH KL-6 improved, abnormal shadows chest high-resolution...
The anti-melanoma differentiation-associated gene 5 (MDA-5) antibody is a marker of clinically amyopathic dermatomyositis (CADM) and rapidly progressive interstitial lung disease (ILD) with acute respiratory failure. A 35-year-old woman cervical cancer showed Gottron's papules, severe hypoxemia, diffuse ground-glass opacities on chest computed tomography. She was diagnosed ILD associated CADM. Her serum positive for the anti-MDA-5 antibody. Combination therapy corticosteroids,...
Abstract A 29‐year‐old man presented to our hospital with severe eosinophilic asthma. He needed a short OCS burst for exacerbation of asthma once every 1 or 2 months, although he used high dose inhaled corticosteroids and long‐acting beta‐2 agonists. Chest CT showed multiple mucous plugs bronchiectasis, but further examination found that did not meet the diagnostic criteria allergic bronchopulmonary aspergillosis. After starting dupilumab his asthma, control improved without exacerbation....
Pulmonary alveolar proteinosis (PAP) is a rare disease of unknown aetiology characterized by accumulations lipoproteinaceous material within the alveoli. The macrophages become increasingly foamy, and are thought to have role in pathogenesis PAP. However, mechanisms macrophage recruitment unclear. In bronchoalveolar lavage fluid (BALF) four patients with PAP 20 normal control subjects, following were examined: monocyte chemotactic activity due chemokine chemoattractant protein (MCP)-1 use...
Rapidly progressive interstitial pneumonias (RPIPs) associated with clinically amyopathic dermatomyositis (CADM) are highly resistant to therapy and have a poor prognosis. Multimodal therapies, including direct hemoperfusion using polymyxin B-immobilized fiber column (PMX-DHP), protective effect on RPIPs. We evaluated the effects of PMX-DHP CADM-associated retrospectively enrolled 14 patients RPIPs acute respiratory failure treated PMX-DHP, corticosteroids, immunosuppressive agents. Clinical...
Here, we present real-world data on the incidence and risk factors of acute exacerbation (AE) in patients with chronic fibrotic interstitial pneumonia (CFIP) treated antifibrotic agents, which has been previously poorly documented.We retrospectively examined clinical characteristics, AE a cohort 100 CFIP (n = 75, idiopathic pulmonary fibrosis [IPF]; n 25, other conditions), all whom received agents setting.The median follow-up was 17.4 months (interquartile range [IQR], 6.6 to 26.7 months)....