A5020668759- Diversity and Impact of Dance
- Human Motion and Animation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Sports injuries and prevention
- Winter Sports Injuries and Performance
- Sports Dynamics and Biomechanics
- Cancer Immunotherapy and Biomarkers
- Sports Performance and Training
- Autophagy in Disease and Therapy
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Human Pose and Action Recognition
- Foot and Ankle Surgery
- Music Technology and Sound Studies
- Cancer-related molecular mechanisms research
- Musicians’ Health and Performance
- Pulmonary Hypertension Research and Treatments
- Bladder and Urothelial Cancer Treatments
- Ferroptosis and cancer prognosis
- Sport Psychology and Performance
- Action Observation and Synchronization
- Monoclonal and Polyclonal Antibodies Research
- Lower Extremity Biomechanics and Pathologies
- Toxin Mechanisms and Immunotoxins
- Chronic Kidney Disease and Diabetes
- Lung Cancer Research Studies
Nagoya Gakuin University
2010-2025
Center for Cancer Research
2021-2024
National Institutes of Health
2023-2024
National Cancer Institute
2021-2023
Kumamoto University
2017-2020
Jikei University School of Medicine
2016-2019
Kumamoto University Hospital
2013-2019
State Key Laboratory of Respiratory Disease
2016
National Center for Global Health and Medicine
2016
Toray Industries, Inc. (Japan)
2003-2013
Abstract Ferroptosis is a necrotic form of regulated cell death (RCD) mediated by phospholipid peroxidation in association with free iron-mediated Fenton reactions. Disrupted iron homeostasis resulting excessive oxidative stress has been implicated the pathogenesis chronic obstructive pulmonary disease (COPD). Here, we demonstrate involvement ferroptosis COPD pathogenesis. Our vivo and vitro models show labile accumulation enhanced lipid concomitant non-apoptotic during cigarette smoke (CS)...
Accumulation of profibrotic myofibroblasts in fibroblastic foci (FF) is a crucial process for development fibrosis during idiopathic pulmonary (IPF) pathogenesis, and transforming growth factor (TGF)-β plays key regulatory role myofibroblast differentiation. Reactive oxygen species (ROS) has been proposed to be involved the mechanism TGF-β-induced Metformin biguanide antidiabetic medication its pharmacological action mediated through activation AMP-activated protein kinase (AMPK), which...
Cigarette smoke (CS)-induced accumulation of mitochondrial damage has been widely implicated in chronic obstructive pulmonary disease (COPD) pathogenesis. Mitophagy plays a crucial role eliminating damaged mitochondria, and is governed by the PINK1 (PTEN induced putative protein kinase 1)-PRKN (parkin RBR E3 ubiquitin ligase) pathway. Although both increased reduced PRKN have COPD pathogenesis association with mitophagy, there are conflicting reports for mitophagy progression. To clarify...
Abstract Fibroblastic foci, known to be the leading edge of fibrosis development in idiopathic pulmonary (IPF), are composed fibrogenic myofibroblasts. Autophagy has been implicated regulation myofibroblast differentiation. Insufficient mitophagy, mitochondria-selective autophagy, results increased reactive oxygen species, which may modulate cell signaling pathways for Therefore, we sought investigate regulatory role mitophagy differentiation as a part IPF pathogenesis. Lung fibroblasts were...
Introduction: The mechanism of foot injury in ballet dancers can be understood by measuring the forces exerted on pointe shoes. In this study, we aimed to reveal vertical applied toes a shoe during movements time series using modified pressure sensor. Methods: Three wore their shoes equipped with sensors replace usual toe pads. They performed 2 tasks: (1) holding posture right leg for 5 seconds and (2) jumping times while pointe, force platform. Their were captured 10-camera motion-capture...
Pirfenidone (PFD) is an anti-fibrotic agent used to treat idiopathic pulmonary fibrosis (IPF), but its precise mechanism of action remains elusive. Accumulation profibrotic myofibroblasts a crucial process for fibrotic remodeling in IPF. Recent findings show participation autophagy/mitophagy, part the lysosomal degradation machinery, IPF pathogenesis. Mitophagy has been implicated myofibroblast differentiation through regulating mitochondrial reactive oxygen species (ROS)-mediated...
Accumulation of profibrotic myofibroblasts is involved in the process fibrosis development during idiopathic pulmonary (IPF) pathogenesis. TGFB (transforming growth factor β) one major cytokines for myofibroblast differentiation and NOX4 (NADPH oxidase 4) has an essential role TGFB-mediated cell signaling. Azithromycin (AZM), a second-generation antibacterial macrolide, pleiotropic effect on cellular processes including proteostasis. Hence, we hypothesized that AZM may regulate levels by...
A disruption of immune checkpoints leads to imbalances in homeostasis, resulting immune-related adverse events. Recent case studies have suggested the association between checkpoint inhibitors (ICIs) and disorders coagulation-fibrinolysis system, implying that systemic activation may impact a balance clotting bleeding. However, little is known about system disorder with efficacy ICIs. We retrospectively evaluated 83 lung cancer patients who received ICI at Kumamoto University Hospital. The...
Acute exacerbation of interstitial lung disease (AE-ILD) is the most serious complication in cancer patients with pre-existing ILD receiving chemotherapy. The role vascular endothelial growth factor (VEGF) pathogenesis AE-ILD conflicting. influence bevacizumab (Bev), a monoclonal antibody against VEGF, on remains unclear. We examined effect Bev reducing risk non-squamous non-small cell (NSCLC) analysed incidence and outcomes 48 advanced NSCLC who received first-line chemotherapy (Bev group,...
Foot injury is one of the major problems that afflict ballet dancers. Measuring force applied to foot in pointe shoes can be a way identify factors causing injuries are associated with shoes. However, suitable sensor for measuring pressure has not yet been developed. In this article, we propose using pressure-sensitive film which magnitude correlates intensity color, used measurement The advantage method two-fold: first, it measure at many locations on toes high spatial resolution and...
Abstract Background: Small cell lung cancer (SCLC) is the most aggressive type of with 5-year survival 7%. Besides chemotherapy, immune checkpoint blockade (ICB) part treatment regimen but only a subset patients derive benefit. Tumor tissue can identify distinct subtypes therapeutic vulnerabilities. Need for prompt and limited access to biopsies at relapse highlight demand noninvasive methods monitor response. Methods: We used sequential blood samples from relapsed/refractory SCLC enrolled...
Abstract ASCP is a rare and highly aggressive variant of pancreatic ductal adenocarcinoma (PDAC) with especially poor prognosis because it frequently refractory to standard chemotherapy. Previous work has demonstrated that upregulation the Myc oncogene an important driver ASCP. Minnelide oral superenhancer inhibitor drug downregulates expression in PDAC safe administer patients. In this Phase II, single institution, open label, arm study, patients previously treated, RECIST-measurable,...
OBJECTIVE The prostacyclin analog, beraprost sodium (BPS), was examined for its potential to improve the symptoms of obesity-type diabetes (i.e., hyperglycemia, hyperinsulinemia, dyslipidemia, histopathologic changes, and diabetic complications). RESEARCH DESIGN AND METHODS Obese Zucker rats, an experimental model genetic obesity-induced type 2 diabetes, were repeatedly administered BPS at oral doses 0.2 or 0.6 mg · kg−1 day−1 b.i.d. 12 weeks, serum chemistry, urinalysis, examination...
Abstract Introduction The impact of immune checkpoint blockade on immunity in cancer patients is not completely elucidated due to the complexity network. Recent studies have revealed a significant role programed cell death‐ligand 2 (PD‐L2) negatively controlling production CD4+ T helper type (Th2) cytokines and airway hypersensitiveness, suggesting hypo‐responsive Th2 cells via PD‐1/PD‐L2 inhibitory pathway lung could be reawaken by PD‐1 therapy. Methods We describe first report acute...
In hip-hop dance contests, a procedure for evaluating performances has not been clearly defined, and objective criteria evaluation are necessary. It is assumed that most techniques have common motion characteristics by which judges determine the dancer's skill level. This study aimed to extract may be linked higher evaluations judges. Ten expert 12 nonexpert dancers performed basic rhythmic movements at rate of 100 beats per minute. Their were captured using capture system, eight evaluated...
Abstract Background ONC201 is a small molecule that can cause nonapoptotic cell death through loss of mitochondrial function. Results from the phase I/II trials in patients with refractory solid tumors demonstrated tumor responses and prolonged stable disease some patients. Methods This single-arm, open-label, II clinical trial evaluated efficacy at recommended dose (RP2D) recurrent or metastatic breast endometrial cancer. Fresh tissue biopsies blood were collected baseline cycle 2 day for...
Prolonged exposure to hyperglycemia is one of the key factors induce progressive diabetic nephropathy in humans. We examined whether or not same phenomenon observed a nonobese type 2 diabetes model, Goto-Kakizaki (GK) rats.Urine and serum samples from GK Wistar rats were collected measure biochemical parameters renal function. The kidneys these animals histopathologically immunohistochemically analyzed.Moderate was sustained during experimental period. Noticeable morphological changes such...
Hallux valgus is a serious medical concern for classical ballet dancers. Although it well-known that progression of hallux related to inappropriate movement techniques in ballet, the kinematic relationship between degree and has not been substantiated. To develop proper training methods prevent valgus, this study aimed investigate ballet. Seventeen female dancers at advanced college-level participated study. Kinematic analysis standing plié first position was conducted via video capture...
Ankle taping is commonly used to prevent ankle sprains. However, kinematic assessments investigating the biomechanical effects of have provided inconclusive results. This study aimed determine effect on external joint moments during a drop landing tilted surface at 25°. Twenty-five participants performed landings force platform that caused inversion with and without taping. Landing kinematics were captured using motion capture system. External moment, angular impulse due medio-lateral...
The evaluation of hip hop dancers presently lacks clearly defined criteria and is often dependent on the subjective impressions judges. Our study objective was to extract hidden motion characteristics that could potentially distinguish skill levels examine relationship between performance kinematics judging scores. Eleven expert, six nonexpert, nine novice participated in study, where each performed “wave” as an experimental task. movements their upper extremities were captured by a capture...