Takuya Ono

ORCID: 0000-0002-0960-3532
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About
Contact & Profiles
Research Areas
  • Sarcoma Diagnosis and Treatment
  • Cardiac electrophysiology and arrhythmias
  • Cardiovascular Syncope and Autonomic Disorders
  • Virus-based gene therapy research
  • Bone Tumor Diagnosis and Treatments
  • ECG Monitoring and Analysis
  • Heart Rate Variability and Autonomic Control
  • Oral and Maxillofacial Pathology
  • Cardiac Arrhythmias and Treatments
  • Peptidase Inhibition and Analysis
  • CAR-T cell therapy research
  • Cancer Genomics and Diagnostics
  • Protein Degradation and Inhibitors
  • COVID-19 Clinical Research Studies
  • Tissue Engineering and Regenerative Medicine
  • Neurofibromatosis and Schwannoma Cases
  • Atrial Fibrillation Management and Outcomes
  • Blood Pressure and Hypertension Studies
  • Vascular Tumors and Angiosarcomas
  • Intraperitoneal and Appendiceal Malignancies
  • Electrospun Nanofibers in Biomedical Applications
  • Neurobiology and Insect Physiology Research
  • Thermal Regulation in Medicine
  • Cancer Cells and Metastasis
  • Neuroendocrine Tumor Research Advances

Yamagata University
2025

Nagasaki University
2017-2024

National Cancer Research Institute
2021-2024

Tokyo Women's Medical University Adachi Medical Center
2017-2023

National Cancer Centre Japan
2021-2023

Tokyo Women's Medical University
2023

Toho University
2017

Toho University Ohashi Medical Center
2017

Okayama Medical Center
2017

Nippon Medical School
2003-2015

Abstract This study aimed to compare the treatment plans of x‐ray SBRT and scanning carbon ion radiation therapy (CIRT) for localized lung tumors, evaluate dose dependence tumor size tumor‐to‐heart distance. For phantom verification, we used a chest with spherical simulated tumor. Treatment 3‐dimensional conformal (3D‐CRT), volumetric modulated arc (VMAT), CIRT were created. GTVs created in sizes ranging from 0.5 5 cm diameter, on GTV diameter was evaluated each plan. patient validation, 30...

10.1002/acm2.14618 article EN cc-by Journal of Applied Clinical Medical Physics 2025-02-11

Although cases of respiratory bacterial infections associated with coronavirus disease 2019 (COVID-19) have often been reported, their impact on the clinical course remains unclear. Herein, we evaluated and analyzed complication rates infections, causative organisms, patient backgrounds, outcome in Japanese patients COVID-19.We performed a retrospective cohort study that included inpatients COVID-19 from multiple centers participating Japan Taskforce (April 2020 to May 2021) obtained...

10.1186/s12890-023-02418-3 article EN cc-by BMC Pulmonary Medicine 2023-04-26

Scaffolds play a key role in the process of regeneration and morphogenesis tissue or organ. We have developed novel sonication decellularization system to prepare decellularized bio-scaffolds short treatment time. The aim study is investigate condition that completely decellularize meniscus can be changed as well maintain biomechanical parameters scaffolds. samples were using treatment. treated evaluated histologically by EVG for cell removal, picrosirius red content collagen type I III,...

10.1109/embc.2013.6611157 article EN 2013-07-01

10.1016/j.jiac.2023.01.006 article EN publisher-specific-oa Journal of Infection and Chemotherapy 2023-01-20

GANG, Y., et al. : QT Dispersion Has No Prognostic Value in Patients with Symptomatic Heart Failure: An ELITE II Substudy. This study prospectively investigated 3,118 standard 12‐lead ECGs recorded 1,804 patients, who participated the Losartan Failure Survival Study—ELITE clinical trial. After exclusion of patients rhythms other than sinus, or atrioventricular block, poor quality ECGs, 986 (703 men, mean age 71 ± 7 years) baseline were retained, whom 615 had follow‐up 4 months after...

10.1046/j.1460-9592.2003.00057.x article EN Pacing and Clinical Electrophysiology 2003-01-01

The budding yeast, Saccharomyces cerevisiae, is an attractive host for studying G protein-coupled receptors (GPCRs). We developed a system in which peptide ligand specific GPCR displayed on yeast plasma membrane. model described here based membrane display of analogue α-factor, Ste2p, the that activates pheromone response pathway. α-Factor analogues, containing linkers varying lengths and produced cells, became attached to cell by linking glycosylphosphatidylinositol (GPI)-anchored protein...

10.1093/jb/mvs027 article EN The Journal of Biochemistry 2012-03-08

This study examined the feasibility of using indices obtained from a long term Holter ECG record for sudden cardiac arrest (SCA) risk stratification. The ndices tested were QT-RR interval co-variability and alternans ratio percentile (ARP(θ)) which is defined as θ(th) ratios over 24 hour period. co-variabilities are evaluated by serial correlation coefficient between QT RR trend sequences (QTRC). Previously reported Kalman filter technique simple smoothing spline method estimation compared....

10.1109/embc.2015.7319714 article EN 2015-08-01

Objective The present study analyzed the psychological status of healthcare workers in Japan and influencing factors during 2019 coronavirus disease pandemic.

10.2169/internalmedicine.7207-21 article EN Internal Medicine 2021-07-02

Myxofibrosarcoma (MFS) is a highly aggressive malignancy with complex karyotypes and postoperative recurrence tendency, owing to its strong invasiveness. Although systemic chemotherapy considered in patients unresectable MFS, the efficacy of conventional hitherto unclear. Recently, drug screening analysis using large number tumor cell lines has been attempted discover novel therapeutic candidate drugs for common cancers. However, MFS extremely small because low incidence-this hinders...

10.3390/cells11020207 article EN cc-by Cells 2022-01-08

Rat endogenous pyrogen (EP), prepared from the white blood cells of lipopolysaccharide-pretreated rats, produced a fever in both rabbits and rats. The effects human, rabbit, rat EP on body temperatures rats were investigated to clarify differences febrile response each kind EP. latency onset time peak induced by significantly greater than those human rabbit maximum elevation temperature animals was almost identical that In comparison responses various EPs between onset, peak, approximately...

10.1152/ajpregu.1986.250.5.r776 article EN AJP Regulatory Integrative and Comparative Physiology 1986-05-01

Pseudomyxoma peritonei (PMP) is the intraperitoneal accumulation of mucus due to a mucinous tumor. PMP predominantly occurs in low-grade carcinomas. The incidence rate one two cases per million people year. standard therapy comprises complete cytoreductive surgery and hyperthermic chemotherapy. recurs about 50% patients, 30-40% are unable receive treatment because its invasiveness. Therefore, novel therapies utmost necessity. For basic pre-clinical research, patient-derived cell lines...

10.3390/jpm12020258 article EN Journal of Personalized Medicine 2022-02-10
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