A5012276632- Hepatitis B Virus Studies
- Occupational and environmental lung diseases
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Viral gastroenteritis research and epidemiology
- RNA Interference and Gene Delivery
- Cancer Research and Treatments
- Animal Virus Infections Studies
- Renal cell carcinoma treatment
- Renal and related cancers
- RNA Research and Splicing
- Medical Imaging and Pathology Studies
- Virus-based gene therapy research
- Ubiquitin and proteasome pathways
- Pleural and Pulmonary Diseases
- Immunotherapy and Immune Responses
- Tuberous Sclerosis Complex Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- DNA Repair Mechanisms
- Vascular Tumors and Angiosarcomas
- Bacteriophages and microbial interactions
- Immune Cell Function and Interaction
- Occupational exposure and asthma
- Thyroid Cancer Diagnosis and Treatment
- RNA and protein synthesis mechanisms
Juntendo University
2015-2025
Tokyo Metropolitan Geriatric Hospital
2025
Japanese Foundation For Cancer Research
2000-2004
Cancer Institute (WIA)
1995-2003
The Cancer Institute Hospital
1994-2001
Fox Chase Cancer Center
1993-1998
Ehime University
1990-1993
National Institute of Health Sciences
1991
National Institute of Infectious Diseases
1989-1990
Cancer-associated fibroblasts (CAFs) play a significant role in human breast cancer as major stromal component. While their promoting proliferation and malignancy through interaction with cells the tumor microenvironment is known, exact mechanisms behind this are not fully understood. Our study reveals that lymphoid enhancer-binding factor 1 (LEF1), central transcription for Wnt/β-catenin signaling, expressed experimentally generated tumor-promoting CAFs (exp-CAFs) well from patients,...
Earlier studies have suggested that transient hepadnavirus infections in mammals are associated with virus replication a large fraction of hepatocytes. Although the viremia occurred during some individuals would presumably lead to all hepatocytes, these did not reveal if this was case. The question extent hepatocyte infection therefore reinvestigated because implications results for mechanisms clearance. Woodchucks were inoculated woodchuck hepatitis virus, and course hepatic determined....
Persistent hepatitis C virus (HCV) infection is associated with the development of human hepatocellular carcinoma (HCC), although mechanism HCV-related hepatocarcinogenesis remains unclear. Recently, however, close relationships between HCC and mitogen-activated protein kinase (MAPK)/extracellular signal-regulated (ERK) cascade have been described. In present study, we investigated effects HCV core on this MAPK/ERK cascade. significantly activated cascade, including Elk1. We also examined...
Abstract Purpose: The development of hepatocellular carcinoma is associated with the chronic inflammation liver caused by various factors such as hepatitis B or C virus infection. Previously, we reported DNA binding protein A (dbpA) a candidate molecule that can accelerate inflammation-induced hepatocarcinogenesis. DbpA belongs to Y-box family, and protein-1 (YB-1), prototype member this be prognostic marker malignant diseases other than carcinoma. purpose study examine significance...
Objectives: The aim of this study was to identify factors that predict recurrence by comparing low-dose and standard-dose Bacillus Calmette-Guérin (BCG) induction therapy in patients with non-muscle invasive bladder cancer (NMIBC). Methods: A total 273 consecutive NMIBC who received (40 mg) or (80 BCG intravesical instillation between January 2004 December 2023 were analyzed. Recurrence-free survival (RFS) rates assessed using the Kaplan–Meier method log-rank test. Univariate multivariate...
The poor prognosis of hepatocellular carcinoma (HCC) is partly the result high rate recurrence that caused either by intrahepatic metastasis (IM) or independent multicentric occurrence (MO). For convenience, discrimination IM and MO based on pathological findings, but reliable parameters are not sufficiently established. In case hepatitis B virus (HBV)–associated HCC, molecular from can be achieved comparison integrated HBV DNAs. However, Southern blotting cannot used for this purpose when...
HepG2 cells, known to support the replication and virion formation of hepatitis B virus (HBV), were transfected with a cosmid constructed contain 12 tandem head-to-tail repeats HBV genome for effective expression. We detected previously identified RNAs 3.3, 2.3, 2.0 kilobases (kb) that code core antigen, large surface middle/major respectively. also four additional 2.1, 1.7, 1.1, 0.7 kb [the lengths exclude poly(A) tail]. S1 mapping nucleotide sequencing data showed 2.1-kb RNA is spliced...
Human hepatitis delta virus (HDV), obtained from the serum of an experimentally infected woodchuck, was injected into either peritoneal cavity or tail vein both adult CB17 mice and with a severe combined immunodeficiency (CB17-scid mice). Three lines evidence indicated that able to reach liver infect hepatocytes: (i) amount HDV genomic RNA detected in by Northern (RNA) analysis increased during first 5 10 days postinoculation, reaching peak about threefold original inoculum; (ii) also viral...
ERC/mesothelin is expressed in mesothelioma and other malignancies. The gene (MSLN) encodes a 71-kDa precursor protein, which cleaved to yield 31-kDa N-terminal (N-ERC/mesothelin) 40-kDa C-terminal (C-ERC/mesothelin) proteins. N-ERC/mesothelin soluble protein has been reported be diagnostic serum marker of ovarian cancer. Gastric cancer tissue also expresses C-ERC/mesothelin, but the significance N-ERC levels for diagnosing gastric not yet studied. We examined latter issue present study as...
A modified AFLP (amplified fragment length polymorphism) method was employed to isolate genes differentially expressed in renal carcinogenesis of Tsc2 gene mutant (Eker) rats. One gene, selected for further investigation, named "Niban" "second" Japanese), because it is the second new be found after Erc (expressed carcinoma) our laboratory. Importantly, well even small primary rat Eker tumors, more than progressed cell lines, and also human carcinoma cells, but not normal or kidneys....
Previously, we reported that a 61-bp subgenomic HBV DNA sequence (designated as 15AB, nt 1855-1915) is hot spot for genomic recombination and cellular protein binding to 15AB may be the putative recombinogenic protein. In present study, established existence of 15AB-like in human rat chromosomal by Southern blot analysis. The isolated from chromosome demonstrated 80.9% identity with 5'-CCAAGCTGTGCCTTGGGTGGC-3', at 1872-1892 hepatitis B virus genome, thought essential region recombination....
Microsatellite instability (MSI), which reflects loss of DNA mismatch repair (MMR) activity, and immunohistochemistry (IHC) for MMR proteins are employed as screening examinations Lynch syndrome (LS). Recent studies revealed that there is a population MSI-high tumors in sporadic endometrial cancer (EC). However, MSI data Japanese EC patients scarce. Furthermore, estrogen-dependent (type I) generally considered to arise from hyperplasia. Because LS usually associated with type I EC, we...
Mesothelioma is a rare, aggressive malignancy with poor outcome, and has limited treatment options. The aim of this study was to perform comprehensive analysis programmed death ligand 1 (PD‐L1) B7 homolog 3 (B7‐H3) expression in mesothelioma. We investigated the protein PD‐L1 B7‐H3 their potential correlation histological subtype, which might help develop new therapies targeting these immune checkpoint molecules. Expression performed by immunohistochemistry using serial tissue sections...