Deregulation of the normal cellular apoptotic function is a fundamental element in etiology most cancers and anti-apoptotic B cell lymphoma 2 (BCL‑2) protein family known to play crucial role regulation this function. Overexpression has been implicated some cancers, such that agents could inhibit their over-activity are now being explored for anticancer drug development. A number studies have revealed potential Morinda lucida-derived extracts compounds. In search more inhibitors from plant...

Morbidity and mortality rates are on the upward trajectory globally, probably due to lack of effective treatments poor healthcare. Most drugs are, however, characterized by serious side effects upon long usage. It is, therefore, imperative explore natural sources for efficient therapeutics with little or no effects. This paper outlines therapeutic potentials endophytes using published articles in both Web Science (WoS) Scopus (1990–2020). Scientific evidences discussed this review suggest...

Abstract Background Endophytes have continued to receive increased attention worldwide, probably, due the enormous biotechnological potentials spanning through various industrial sectors. This paper outlines of endophytes in biocontrol and enzyme production, possible contribution towards achieving agro-industrial sustainability using published articles on both Web Science Scopus (1990–2020). Main body abstract review discusses potential produce novel secondary metabolites with effective...

The types and mechanisms of atrazine-metolachlor toxicity, an herbicide composed atrazine (ATR) metolachlor (MET), need to be further investigated. This study evaluated the toxic actions ATR-MET by in vivo silico methods. Here, varying doses were orally administered rats once daily for twenty-one days using normal saline as control. Molecular docking was used characterize binding ATR MET with androgen receptor (AR) predict their potential endocrine-disrupting effects, testosterone benchmark....

Diarrhea is a prevalent gastrointestinal problem associated with fatal implications. It huge public health concern that requires better alternatives to current drugs. This study investigated the mechanisms involved in antidiarrheal activity of Anacardium occidentale (Ao) stem bark extract, plant commonly used management diarrhea Nigeria. Methanolic extract was partitioned into three fractions: hexane fraction, ethyl acetate fraction (AoEF) and methanol fraction. In vitro studies on effect...

Human exposure to aluminum is inevitable, and one of the most adverse health effects a decrease in male fertility rates. Therefore, this study investigated ameliorative an aqueous extract from Laurus nobilis-bay leaf (BL) on chloride (AlCl3)-induced testicular toxicity rats.Twenty-four Wistar rats were divided into four groups (n = 6, each group): The control (group 1) received normal saline; Group 2 animals intraperitoneally administered with 30 mg/kg body weight (BW) AlCl3; Groups 3 4...

Objective: To investigate the potential of N -acetylcysteine (NAC) and zinc sulphate (ZnSO 4 ) in mitigating reproductive dysfunction caused by di-2-ethylhexyl phthalate (DEHP) rats to understand underlying mechanisms, specifically oxidative stress sex hormone receptor activity. Methods: Thirty-five male Wistar were randomly divided into five equal groups ( n =7 per group). Group 1 was administered 0.5 mL distilled water served as control group. 2 given only DEHP (750 mg/kg/day), while group...

Finasteride used for treating benign prostatic hyperplasia is associated with undesirable side effects via oxidative stress related mechanisms. This study employed in vivo and silico methods to investigate the protective role of hesperidin against testicular toxicity induced by finasteride possible molecular mechanisms involved. Male Wistar rats were randomized into four groups six animals each. Group I (control) administered distilled water, group II received (3.1 mg/kg bw), III (100 while...

Abstract Background Cancer is responsible for high morbidity and mortality globally. Because the overexpression of histone deacetylases (HDACs) one molecular mechanisms associated with development progression some diseases such as cancer, studies are now considering inhibition HDAC a strategy treatment cancer. In this study, receptor-based in silico screening was exploited to identify potential inhibitors among compounds isolated from Cajanus cajan , since reports have earlier confirmed...

Nymphaea lotus is used traditionally for the treatment of diabetes and its complications. However, mode action likely bioactive phytochemicals involved are not yet fully explored. GC-MS analysis was employed to identify inherent compounds in N. leaves. To gain an insight into antidiabetic this plant, identified were subjected computational studies against four molecular targets diabetes, dipeptidyl peptidase-4, glycogen synthase kinase 3, NADPH oxidase (NOX), sodium-glucose co-transporter-2,...

Kolaviron (KV) is a biflavonoid isolate mixture of defatted Garcinia kola seed extract patented for treatment hepatic disorders and inflammation-related conditions. The clinical experimental-based reports on liver impairment valproic acid, front-line synthetic drug used in the epilepsy gained public attention. Therefore, mitigative effect perturbed redox status genotoxicity caused by sodium valproate was investigated murine tissue. at dose 200 mg/kg (SVP) 500 were administered orally...

Neurological disorders remain a global health challenge, with Alzheimer's Disease (AD) as the most famous cause of dementia in old people. Nevertheless, culinary spices and herbs have shown promising potentials management neurological diseases. This study aimed at investigating neuroprotective property aqueous extracts bay leaf (Laurus nobilis) rosemary (Rosmarinus officinalis) by assessing antioxidant activity effects on key-enzymes implicated AD: Acetylcholinesterase (AChE)...

Different parts of Psidium guajava are consumed as food and used for medicinal purposes around the world. Although studies have reported their antiproliferative effects via different biochemical mechanisms, modulatory on epigenetic modification DNA molecules histone deacetylases (HDACs) largely unknown.This study was carried out to investigate deacetylase 6 (HDAC6) 10 (HDAC10) binding propensity guava-derived compounds, using in silico methods, other identify compounds with HDAC inhibitory...