A5030736846- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Medicinal Plants and Neuroprotection
- Biochemical effects in animals
- Alzheimer's disease research and treatments
- Ginkgo biloba and Cashew Applications
- Phytochemistry and Biological Activities
- Parkinson's Disease Mechanisms and Treatments
- Aldose Reductase and Taurine
- Treatment of Major Depression
- Neurological Disease Mechanisms and Treatments
- Pharmacological Effects of Natural Compounds
- Coenzyme Q10 studies and effects
- Phytochemicals and Medicinal Plants
- Birth, Development, and Health
- Natural Antidiabetic Agents Studies
- Medicinal Plant Extracts Effects
- Prenatal Substance Exposure Effects
- Anesthesia and Neurotoxicity Research
- Ethnobotanical and Medicinal Plants Studies
- Neurotransmitter Receptor Influence on Behavior
- Circadian rhythm and melatonin
- Regulation of Appetite and Obesity
Delta State University
2020-2025
University of Victoria
2021-2025
University of Ibadan
2016-2023
Delta Air Lines (United States)
2022
Delta State University
2022
Centro Científico Tecnológico - San Luis
2022
PAMO University of Medical Sciences
2019-2020
Rivers State University
2019-2020
A decrease in the levels of antioxidant arsenals exacerbate generation reactive oxygen/nitrogen species, leading to neurochemical dysfunction, with significant impact on pathogenesis psychotic disorders such as schizophrenia. This study examined preventive and reversal effects diosgenin, a phyto-steroidal saponin functions mice treated ketamine which closely replicates schizophrenia-like symptoms human laboratory animals. In phase, adult cohorts were clustered into 5 groups (n = 9). Groups 1...
Oxidative stress and aberrant inflammatory response have important implications in cyclosporin-induced reproductive functions. Previous studies shown that agents with antioxidant anti-inflammatory activities might be beneficial reversing impairment. Lutein is a naturally occurring compound properties. However, the effect of lutein against impairment remains complete. Hence, we investigated protective lutein, specifically focusing on role nuclear factor erythroid 2 related factor-2...
Flavonoids are naturally occurring bioactive phytochemical metabolites widely known to prevent and suppress several human diseases, important sources of therapeutic compounds from plants. Evidence derived previous studies suggests that naringin, a neuroactive flavonoid possess functional beneficial neurobehavioral effects including anxiolytic, antidepressant memory enhancing properties. However, literature search revealed no have been carried out evaluate the possible biochemical mechanisms...
Previous reports revealed that increased oxidative stress with up-regulated inflammatory proteins and apoptotic factors have serious implications in busulfan-induced chemo-brain testicular damages. Hence, we investigated the potential reversal effects of kolaviron (KV), a neuro-active extract rich flavonoids proven anti-oxido-inflammatory anti-apoptotic properties, on damage, proteins, apoptosis brains testes male rats. In treatment-regimen, animals groups 1 2 had saline (10 ml/kg/p.o./day)...
Inhibition of neuroinflammation through N-methyl-D-aspartate receptor (NMDAR) regulation can provide normalization neurochemical homeostasis and neurotrophic support in the pathogenesis psychiatric disorders with complex symptoms such as schizophrenia. Accordingly, preventive reversal effects potential mechanisms diosgenin, a phyto-steroidal sapogenin anti-inflammatory functions, was evaluated ketamine (an NMDAR antagonist) model schizophrenia mice. Adult male mice were allotted into 5...
Post-traumatic stress disorder (PTSD) is a mental linked to neurochemical, hypothalamic-pituitary-adrenal (HPA)-axis dysregulations, inflammatory and pro-oxidant challenges in response traumatic events. It one of the leading causes neurocognitive declines, hence prompting need for pharmacological intervention. However, impact diosgenin, naturally occurring steroidal saponin with adaptogenic-like action, on PTSD-induced neuropsychiatric disturbances its underlying mechanisms are unknown. In...