A5035595889- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Heavy Metal Exposure and Toxicity
- Medicinal Plant Extracts Effects
- Neurological Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Pharmacological Effects of Natural Compounds
- Neuroinflammation and Neurodegeneration Mechanisms
- Schizophrenia research and treatment
- Ginkgo biloba and Cashew Applications
- Olfactory and Sensory Function Studies
- Treatment of Major Depression
- Adipokines, Inflammation, and Metabolic Diseases
- Cannabis and Cannabinoid Research
- Medicinal Plants and Neuroprotection
- Sleep and Wakefulness Research
- Drug-Induced Hepatotoxicity and Protection
- Neurogenesis and neuroplasticity mechanisms
- Folate and B Vitamins Research
- Circadian rhythm and melatonin
- Gut microbiota and health
- Fatty Acid Research and Health
- Neurotransmitter Receptor Influence on Behavior
- Mitochondrial Function and Pathology
- Ginger and Zingiberaceae research
Olusegun Agagu University of Science and Technology
2023-2024
University of Medical Sciences, Ondo
2023-2024
University of Ibadan
2021-2024
Academia Sinica
2024
National Yang Ming Chiao Tung University
2024
Delta State University
2024
University of Ilorin
2018-2021
Post-traumatic stress disorder (PTSD) is a mental linked to neurochemical, hypothalamic-pituitary-adrenal (HPA)-axis dysregulations, inflammatory and pro-oxidant challenges in response traumatic events. It one of the leading causes neurocognitive declines, hence prompting need for pharmacological intervention. However, impact diosgenin, naturally occurring steroidal saponin with adaptogenic-like action, on PTSD-induced neuropsychiatric disturbances its underlying mechanisms are unknown. In...
Abstract Introduction Lead is the most used nonphysiological neurotoxic heavy metal in world that has been indicated to interfere with cognitive and noncognitive processes via numerous mechanisms. The neuroprotective effect of melatonin well known, but its interaction lead brain remains inconclusive. Objective To assess therapeutic role on deficit, anxiety depressive‐like symptoms matured male Wistar rats exposed a subchronic chloride (PbCl 2 ). Methods Twenty were blindly randomized into...
We investigated the effects of melatonin on sperm parameters and some biochemical markers in lead-exposed male Wistar rats. Lead (50 mg/kg bw/day) and/or (4 or 10 was administered for 4 weeks, while 2-week lead exposure preceded by followed treatment with both doses other groups. reduced glutathione, catalase, adjusted testes weight, semen but did not change malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase, total antioxidant capacity. Though independent prolactin,...
Parkinson's disease (PD) is a chronic neurodegenerative that occurs progressively with time. Current PD treatments are symptomatic moderate effects on striatal dopamine release. Previously, the ethnomedicinal benefits of Zingiber officinale Roscoe have been demonstrated to possess broad range pharmacological benefits, but no single data its effect against nigrostriatal degeneration in model has reported. Proactive neuroprotective and pharmacotherapeutic approaches asymptomatic needed prevent...
The Anthocleista species are used to treat pain, inflammation, and stomach disorders, but the mechanism by which vogelii Planch stem bark ethanol extract (AVSBE) elicits its anti-pain activity is not fully understood. This study elucidates phytochemical signatures of AVSBE along with anti-nociceptive, anti-inflammatory, antioxidant activities in animal models pain inflammation. Gas Chromatography Mass Spectrometry (GC-MS) Lorke's methods were for characterization LD50 determination AVSBE....
Background: Datura stramonium (DS) is a potent plant with psychoactive and anticholinergic properties used to treat human ailments. However, its toxicity or insult can cause cognitive impairments. The present study aimed determine whether donepezil could mitigate this deficit elucidate the potential mechanisms involved in male Wistar rats Methods: Rats were randomly divided into seven groups (n = 5/group). While group 1 received distilled water (10 mL/kg), 2–4 graded doses of DS (50, 100,...
Background
 The antithyroid effect of ketoconazole has been reported. secretion and action melatonin in the thyroid gland are also known. However, possible on ketoconazole-induced is unknown.
 Objective
 We sought to investigate modulatory and/or function female rats.
 Methods
 Groups 1-4 rats respectively underwent 14-day treatment with normal saline, 25 mg/kg ketoconazole, 4 10 melatonin. 5 6 both received were treated simultaneously. 7 8 pretreatment melatonin,...
Abstract Background Lipid profile and redox status play a role in brain (dys)functions. Cannabinoid melatonergic systems operate the contribute to (patho)physiology, but their roles modulation of lipid are not well-known. We studied effect ethanol extract Cannabis sativa (CS) and/or melatonin (M) on anti-oxidant system rat brain. Methods randomly divided twenty-four (24) female Wistar rats into 4 groups ( n = 6 each). Group 1 (control) received distilled water mixed with DMSO. Groups II–IV...
Ethnopharmacological relevance: Carpolobia lutea decoction is widely used as a phytotherapeutic against central nervous system-related disorders including insomnia, migraine headache, and mental illness in West Central Tropical Africa.Aimthis study was designed to investigate the antipsychotic activity of (EECL) mice models psychosis.Methods: Male Swiss (n = 5/group) were given EECL (100, 200, 400, 800 mg/kg), haloperidol (1 clozapine (5 mg/kg) vehicle (10 mL/kg) orally before amphetamine...