A5083255970- Computational Drug Discovery Methods
- Histone Deacetylase Inhibitors Research
- Cholinesterase and Neurodegenerative Diseases
- Pharmacological Effects of Natural Compounds
- Malaria Research and Control
- Antioxidant Activity and Oxidative Stress
- SARS-CoV-2 and COVID-19 Research
- Synthesis and biological activity
- Bioactive Compounds and Antitumor Agents
- Ovarian function and disorders
- Phytochemical compounds biological activities
- Estrogen and related hormone effects
- Phytochemicals and Antioxidant Activities
- Moringa oleifera research and applications
- Morinda citrifolia extract uses
- Essential Oils and Antimicrobial Activity
- Biological Activity of Diterpenoids and Biflavonoids
- Diverse Scientific Research Studies
- Medicinal Plants and Neuroprotection
- Chemical synthesis and alkaloids
- Protein Degradation and Inhibitors
- COVID-19 Clinical Research Studies
- Helicobacter pylori-related gastroenterology studies
- Enzyme function and inhibition
- Phytochemistry and biological activities of Ficus species
University of Ilorin
2014-2024
Wesley University
2022
Mountain Top University
2022
Federal University Lokoja
2022
Abubakar Tafawa Balewa University
2022
Federal University of Technology
2022
Kwara State Polytechnic
2021-2022
Cape Peninsula University of Technology
2022
Neurodegenerative diseases have been characterized by loss of neuron structures as well their functions. This study was designed to assess molecular docking flavonoids from Andrographis paniculata potential acetylcholinesterase, butyrylcholinesterase, and monoamine oxidase inhibitors in the treatment neurodegenerative diseases. Eight identified possible were retrieved PubChem database. The docking, ADMET, Lipinski’s rule five examined using different bioinformatic tools. It shown that only...
Introduction: Emergence of drug resistant strains Plasmodium species has necessitated the search for novel antimalarials with unique mechanisms action. Synthesis hybrid compounds been one approach to tackling this challenge. In study, synthesis artesunate-ellagic acid compound (EA31) from ellagic and artesunate its evaluation antimalarial antioxidant activities using in vitro vivo models were carried out. Method: EA31 was synthesized acid. The against falciparum W2 P. berghei NK65 evaluated,...
With the world threatened by a second surge in number of Coronavirus cases, there is an urgent need for development effective treatment novel coronavirus (COVID-19). Recently, global attention has turned to preliminary reports on promising anti-COVID-19 effect histamine H2-receptor antagonists (H2RAs), most especially Famotidine. Therefore, this study was designed exploit possible molecular basis efficacy H2RAs against coronavirus. Molecular docking performed between four H2RAs, Cimetidine,...
Deregulation of the normal cellular apoptotic function is a fundamental element in etiology most cancers and anti-apoptotic B cell lymphoma 2 (BCL‑2) protein family known to play crucial role regulation this function. Overexpression has been implicated some cancers, such that agents could inhibit their over-activity are now being explored for anticancer drug development. A number studies have revealed potential Morinda lucida-derived extracts compounds. In search more inhibitors from plant...
Diarrhea is a prevalent gastrointestinal problem associated with fatal implications. It huge public health concern that requires better alternatives to current drugs. This study investigated the mechanisms involved in antidiarrheal activity of Anacardium occidentale (Ao) stem bark extract, plant commonly used management diarrhea Nigeria. Methanolic extract was partitioned into three fractions: hexane fraction, ethyl acetate fraction (AoEF) and methanol fraction. In vitro studies on effect...
Polycystic ovary syndrome (PCOS) is a chronic endocrine disorder prevalent in premenopausal women and characterized by range of physiological biochemical abnormalities which may include reproductive, endocrine, metabolic alterations such as insulin resistance. Insulin resistance the hallmark PCOS it predisposes affected subjects to higher risk impaired glucose tolerance type 2 diabetes mellitus (T2DM). In this study, inhibitory activities phytosterols saccharides from aqueous extract Costus...
Neurological disorders remain a global health challenge, with Alzheimer's Disease (AD) as the most famous cause of dementia in old people. Nevertheless, culinary spices and herbs have shown promising potentials management neurological diseases. This study aimed at investigating neuroprotective property aqueous extracts bay leaf (Laurus nobilis) rosemary (Rosmarinus officinalis) by assessing antioxidant activity effects on key-enzymes implicated AD: Acetylcholinesterase (AChE)...
Different parts of Psidium guajava are consumed as food and used for medicinal purposes around the world. Although studies have reported their antiproliferative effects via different biochemical mechanisms, modulatory on epigenetic modification DNA molecules histone deacetylases (HDACs) largely unknown.This study was carried out to investigate deacetylase 6 (HDAC6) 10 (HDAC10) binding propensity guava-derived compounds, using in silico methods, other identify compounds with HDAC inhibitory...
The emergence of 2019 novel Coronavirus (COVID-19 or 2019-nCoV) has caused significant global morbidity and mortality with no consensus specific treatment. We tested the hypothesis that FDA-approved antiretrovirals, antibiotics, antimalarials will effectively inhibit COVID-19 two major drug targets, coronavirus nucleocapsid protein (NP) hemagglutinin-esterase (HE). To test this hypothesis, we carried out a phylogenic analysis genome to understand origins NP HE, also modeled proteins before...
Cholinesterases, beta-secretase 1 (BACE1) and monoamine oxidase (MAO) are significant in the etiology of neurodegenerative diseases. Inhibition these enzymes is therefore a major strategy for development neurotherapeutics. Even though, this has birthed some approved synthetic drugs, they characterized by adverse effects. It therefore, imperative to explore promising alternatives. Consequently, we assessed inhibitory activities endophytes-derived compounds against selected targets towards...
Abstract This study investigated the effect of ethanolic extract Ocimum gratissimum leaves (EEOGL) on letrozole‐induced polycystic ovarian syndrome (PCOS) and determine possible binding effects compounds identified in EEOGL using molecular docking method. After induction letrozole (1 mg/kg), normal (n=4) PCOS (n=16; 4 groups animals/group) were treated for 14 days orally with distilled water ml/kg), metformin (500 clomiphene‐citrate (2 (50 100 mg/kg). 47 docked to androgen receptor (AR),...
Background: Recent studies have observed overexpression of histone deacetylase 7 (HDAC7) and overactivity extracellular signal-regulated kinases 1/2 (ERK1/2) in many tumors; therefore, pharmacological interventions to inhibit HDAC7 ERK1/2 cancerous cells holds great promise cancer treatment. The promising anticancer properties artemisinin artemisinin-derivatives (ARTs) been validated by various experimental reports, including advanced pre-clinical trials. Objective: Our aim this silico study...
The reduced levels of acetylcholine and dopamine lead to Alzheimer's disease (AD) Parkinson's PD, respectively, due the action cholinesterase monoamine oxidase B.Therapeutic options for AD PD involve respective cholinergic monoaminergic inhibitors, considering adverse outcomes cholinergic- monoaminergic- inhibitory therapeutics, phytoconstituents may be promising alternatives. Reports have shown that different extracts calyx Hibiscus sabdariffa exhibit anticholinesterase B properties with...