Papain is a globular cysteine-protease family consisting of single polypeptide chain with three disulfide bridges and sulfhydryl group necessary for proteolytic activity. Its application extensive to the fields medicine food. The aim this study extract, purify characterize papain enzymes from leaves Carica papaya. Crude extracts containing were extracted papaya in Mountain Top University, Nigeria, purified 3-step purification using 70% NH4(SO4)2, DEAE-Cellulose column chromatography Sephadex...

One of the most pressing challenges associated with SARS treatment is emergence new variants that may be transmissible, causing more severe disease or being resistant to current standard treatment. This study aimed identify potential drug candidates from novel imidazole derivatives against SARS-CoV-2 main protease (Mpro), a crucial target for treating viral infection, using computational approach integrated molecular docking and dynamics simulation. In this study, we utilized AutoDock Vina...

The phenothiazine analogs represent one of the privileged structures in medicinal chemistry and there has been an increasing number studies on phenothiazine-containing compounds. In this study, we report synthesis techniques including heterogeneous catalyst-assisted, microwave-assisted, ultrasound-assisted, combinatorial synthesis, as well using cyclization method, transition metal-catalyzed nanoparticle-mediated which have enhanced diversity potential applications unique scaffold also...

Diabetes Mellitus (DM) is a chronic disorder which needs urgent attention. Detection of the disease from grass root using patient risk factors key for early prevention disease. The aim this paper to use Artificial Neural Network (ANN) detection DM. Datasets were collected past records patients suffering DM in General Hospital Kaura Namoda, Nigeria between 2019 2023. hospital and region are selected because most cases reported prevalence about 8% 10%. datasets consists two sample size 400...

Lactic acid bacteria (LAB) have been known to possess bacteriocidal activity resulting from ribosomally synthesized antimicrobial peptides called bacteriocin. This study focused on the characterization of bactericidal bacteriocin PB2 and comprehensive detection pediocin ped-A1 Pediococcus pentosaceus obtained fermented sorghum beverage, Pito, in Nigeria against Escherichia coli ATCC 25922 Listeria monocytogenes 15313. Bacteriocin was purified a 2-step purification using 80% NH4 (SO4)2,...

Fermented products, including Ogi-baba and Pito, provide several health benefits, particularly when probiotics are used in the fermentation process. Probiotic microorganisms exert strain-specific health-promoting activities on humans animals. The objective of this study was to investigate probiotic potentials Lactic-acid bacteria (LAB) isolates from indigenous fermented sorghum products (Ogi-baba Pito). LAB were screened for potential properties by antagonistic activity against eight...

Severe Acute Respiratory Syndrome Coronavirus- 2 (SARS-CoV-2), including the recently reported severe variant B.1.617.2, has been to attack respiratory tract with symptoms that may ultimately lead death. While studies have conducted evaluate therapeutic interventions against virus, this study evaluated inhibitory potential of virtually screened novel derivatives and structurally similar compounds towards SARS-CoV-2 via a computational approach. A molecular docking simulation potentials drug...

S6K1 (ribosomal protein S6 kinase beta-1) is a critical serine/threonine involved in the regulation of various cellular processes, including synthesis, gene expression, and metabolic homeostasis. The structural complexity S6K1, with its multiple isoforms unique domain, allows for diverse functionality across different contexts. In this review, we report intricate structure highlighting significance domain. Additionally, explored tissue-specific expression subcellular localization isoforms,...

generated during metabolic processes [4].Cancer cells have different strategies in escaping destruction, and these are captured its hallmarks [5].The ability to evade immune suppression is one of cancer's hallmarks.Tumor

Polycystic ovary syndrome (PCOS) is a chronic endocrine disorder prevalent in premenopausal women and characterized by range of physiological biochemical abnormalities which may include reproductive, endocrine, metabolic alterations such as insulin resistance. Insulin resistance the hallmark PCOS it predisposes affected subjects to higher risk impaired glucose tolerance type 2 diabetes mellitus (T2DM). In this study, inhibitory activities phytosterols saccharides from aqueous extract Costus...

Palm fatty acid distillate (PFAD) and soybean deodorized (SDD) are two prominent byproducts in the vegetable oil industry; hence, objective of this paper was to characterize physicochemical properties palm biodiesel production. Various properties, including composition, value, iodine saponification viscosity, underwent analysis. Moreover, study identified impurities like moisture, free acids, unsaponifiable matter. This thorough assessment offers essential insights into materials'...

В статье представлены результаты исследования гипогликемической и нейропротекторной эффективности производных 3-оксипиридина, содержащих остаток аскорбиновой кислоты, – веществ с лабораторным шифром ЛХТ-020 ЛХТ-021. У крыс со стрептозотоциновым диабетом как ЛХТ-020, так ЛХТ-021 продемонстрировали способность снижать уровень глюкозы в крови, при этом применение вещества обеспечивало дополнительное снижение медианного уровня гликемии на 0,4 ммоль/л по сравнению эффектом к 14-му дню...

The objective of this study was to investigate the probiotic potentials Lactic-acid bacteria (LAB) isolates from indigenous fermented sorghum products (Ogi-baba and Pito). LAB were screened for potential properties by antagonistic activity against eight enteropathogenic clinical (Escherichia coli, Klebsiella sp., Helicobacter pylori, Bacillus Staphylococcus Salmonella Pseudomonas sp. Listeria monocytogenes) as indicator organisms using agar well diffusion technique. also acidity, bile...

Abstract One of the most pressing challenges associated with SARS treatment is emergence new variants that may be transmissible, causing more severe disease or being resistant to current standard treatment. This study aimed identify potential drug candidates from newly synthesized imidazole derivatives against SARS-CoV-2 Main Protease (Mpro), a crucial target for treating viral infection, using computational approach integrated molecular docking and dynamics simulation. In this study, we...