A5087479613- Systemic Lupus Erythematosus Research
- Antifungal resistance and susceptibility
- Phagocytosis and Immune Regulation
- Erythrocyte Function and Pathophysiology
- Immunotherapy and Immune Responses
- Phenothiazines and Benzothiazines Synthesis and Activities
- Essential Oils and Antimicrobial Activity
- Photodynamic Therapy Research Studies
- Reproductive System and Pregnancy
- Dialysis and Renal Disease Management
- Muscle and Compartmental Disorders
- Synthesis and Catalytic Reactions
- Fungal Plant Pathogen Control
- Erythropoietin and Anemia Treatment
- Fungal Infections and Studies
- Biopolymer Synthesis and Applications
- Heme Oxygenase-1 and Carbon Monoxide
- Immune Cell Function and Interaction
- Synthesis and biological activity
- Infectious Diseases and Mycology
- Phytochemistry and Bioactivity Studies
- Click Chemistry and Applications
- Blood disorders and treatments
- Pharmacogenetics and Drug Metabolism
- Hemoglobin structure and function
Birla Institute of Technology and Science, Pilani
2024
Manipal Hospital
2023
National Institute of Immunology
2014-2021
University College of Medical Sciences
2016
Guru Teg Bahadur Hospital
2016
The phenothiazine analogs represent one of the privileged structures in medicinal chemistry and there has been an increasing number studies on phenothiazine-containing compounds. In this study, we report synthesis techniques including heterogeneous catalyst-assisted, microwave-assisted, ultrasound-assisted, combinatorial synthesis, as well using cyclization method, transition metal-catalyzed nanoparticle-mediated which have enhanced diversity potential applications unique scaffold also...
We investigated in vitro activity of polyene drugs (amphotericin B, Amp B; and nystatin, NYS;) combination with ethylene diamine tetra acetic acid (EDTA) against 8 pathogenic isolates Aspergillus spp.The intensity the drug interactions was assessed using Fractional Inhibitory Concentration Index (FICI) model Combination (CI) model. The were further confirmed by time-kill curve study. best ratio subjected for toxicity analysis MTT haemolytic assay. A significant synergy found between each two...
Immunopathological outcomes in Systemic Lupus Erythematosus (SLE; or lupus) are believed to be autoantibody-mediated. Conditions which promote a Th2 skew (such as pregnancy) should encourage antibody production, worsening antibody-mediated diseases while ameliorating Th1/Th17-mediated diseases. Although an increased propensity towards autoreactivity can observed pregnant lupus patients and lupus-prone mice, whether unique human pregnancy-specific factor contribute such effects is unknown....
The undigested remnants of apoptosis are believed to stimulate the generation autoantibodies in lupus. biological properties initiator, disease-specific IgM antibodies that specifically recognize apoptotic cells, readily detected sera lupus patients, remain unclear. Apoptotic cell-reactive monoclonal (generated from lupus-prone mice), as opposed control IgM, preferentially stimulated maturation bone marrow-derived dendritic cells (BMDCs) derived such mice, relative BMDCs healthy mice. An...
While apoptotic debris is believed to constitute the original antigenic insult in lupus (which characterized by a time-dependent diversification of autoreactivity), whether such and autoantibodies specifically recognizing its constituents mediate differential effects on innate humoral responses lupus-prone mice currently unknown. Apoptotic blebs (as opposed cellular lysate) enhanced preferentially maturation dendritic cells (DCs) from bone marrow precursors drawn mice. Murine, somatically...
Haemoglobin (Hb) has well-documented inflammatory effects and is normally efficiently scavenged; clearance mechanisms can be overwhelmed during erythrocyte lysis. Whether Hb preferentially in lupus triggers broad anti-self responses was assessed. Peripheral blood mononuclear cells (PBMCs) derived from SLE patients secreted higher levels of lupus-associated cytokines when incubated with human than did PBMCs healthy donors, an effect negated by haptoglobin. Ferric murine triggered the...
Background: The fungal genus Aspergillus contains a number of species that are capable causing spectrum diseases in immunocompromised humans. A. fumigatus accounts for approximately 90% life-threatening infections. Poly –acid ligand i.e. EDTA having potent antifungal activity against was investigated its effect on proteins. Objective: foremost objective this research to reveal A.fumigatus proteins inhibited response polyacid EDTA. Methods: profile has been analysed by silver stained gel...
Background: Several studies have suggested that online hemodiafiltration (OL-HDF) may reduce the risk of mortality and improve quality life these patients compared with standard hemodialysis. Methods: Forty stable out on dialysis (20 hemodialysis 20 hemodiafiltration) above age 18 years vintage more than 3 months were followed up for months. Clinical, biochemical parameters along SF-36 score at baseline after follow assessed. Results: At months, statistically significant difference was found...
Background: The Kingdom (Fungi) comprises numerous species that are associated with fungal diseases. Moreover, the resistance, stagnation in development of antifungal agents and unacceptably high mortality rate some resistant fungus indicate alternative therapeutic options should be considered. Objective: objective this study was to find out new targets A.fumigatus response adjunctive combination, i.e., Ketoconazole (KTZ) plus EDTA. Methods: cultured absence presence a sublethal dose (MIC...