A5058351630- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Systemic Sclerosis and Related Diseases
- Chronic Lymphocytic Leukemia Research
- Autoimmune and Inflammatory Disorders Research
- Musculoskeletal pain and rehabilitation
- Transcranial Magnetic Stimulation Studies
- Pain Mechanisms and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Musculoskeletal synovial abnormalities and treatments
- Hepatitis C virus research
- Pain Management and Placebo Effect
- Immunodeficiency and Autoimmune Disorders
- Pain Management and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Vasculitis and related conditions
- Mindfulness and Compassion Interventions
- COVID-19 and Mental Health
- Dermatological and Skeletal Disorders
- Spondyloarthritis Studies and Treatments
- Inflammatory Myopathies and Dermatomyositis
- Skin Diseases and Diabetes
- Chronic Myeloid Leukemia Treatments
- Muscle activation and electromyography studies
All India Institute of Medical Sciences
2016-2025
All India Institute of Medical Sciences Guwahati
2023
All India Institute of Medical Sciences Raipur
2011-2022
All India Institute of Medical Sciences Bhopal
2011-2022
Institute of Medical Sciences
2016-2021
Center for Rheumatology
2021
Cancer Institute (WIA)
2021
Universities UK
2020
Employees' State Insurance Model Hospital
2017-2018
Yahoo (United Kingdom)
2018
To evaluate the efficacy and safety of Janus kinase-1-preferential inhibitor filgotinib versus placebo or tumour necrosis factor-α therapy in patients with active rheumatoid arthritis (RA) despite ongoing treatment methotrexate (MTX).This 52-week, multicentre, double-blind, placebo-controlled active-controlled phase III trial evaluated once-daily oral RA randomised 3:3:2:3 to 200 mg (FIL200) 100 (FIL100), subcutaneous adalimumab 40 biweekly, (through week 24), all stable weekly background...
Background:Recovery of patients with rheumatoid arthritis (RA) depends on several physical and psychological factors, besides pharmacological treatment. Co-morbid depression adversely affects the outcome in RA. Usual medical therapies have a limited scope fail to cure componen t disease. With advanced therapeutic options, achieving state remission has become treatment goal, yoga based mind body intervention (MBI) may provide holistic approach its dimension. Hence, MBIs are need hour as...
Various external stressors and environmental challenges lead to the provocation of immune system in autoimmune diseases like Rheumatoid arthritis (RA). The inappropriate response further triggers cascade inflammatory changes resulting precipitation symptoms hampers quality life (QOL). underlying psycho-somatic component disease requires a holistic approach its treatment dimension rather than use pharmacotherapy. applicability mind-body interventions has become essential today's fast-paced...
Because transethnic analysis may facilitate prioritization of causal genetic variants, we performed a genomewide association study (GWAS) psoriasis in South Asians (SAS), consisting 2,590 cases and 1,720 controls. Comparison with our existing European-origin (EUR) GWAS showed that effect sizes known signals were highly correlated SAS EUR (Spearman ρ = 0.78;
The pathogenesis of rheumatoid arthritis (RA) is characterized by a Th17/Treg cell imbalance. A pro-inflammatory cytokine milieu that promotes the continued proliferation Th17 cells related to development autoinflammation. In RA, T have several hallmarks cellular aging, and they accumulate DNA damage, predisposing occurrence mutations epigenetic alterations. Since onset, progression, treatment response are influenced variety external stressors environmental factors, this study aimed evaluate...
Abstract Objectives Fibromyalgia Syndrome (FMS), is a chronic pain disorder with poorly understood pathophysiology. In recent years, repetitive transcranial magnetic stimulation (rTMS) has been recommended for relief in various disorders. The objective of the present research was to study effect low frequency rTMS over right dorsolateral prefrontal cortex (DLPFC) on status FMS. Methods Ninety diagnosed cases FMS were randomized into Sham-rTMS and Real-rTMS groups. Real (1 Hz/1200 pulses/8...
In Brief Objective Inter-individual variations to methotrexate (MTX) response among rheumatoid arthritis (RA) patients have been attributed clinical heterogeneity and genetic influencing MTX pharmacology. this study, we analyzed the association of polymorphisms in ATIC, AMPD1, ADA, ADORA2A from purine biosynthetic pathway with RA north India. We also assessed cumulative contribution these together those receptor–metabolizer–transporter folate genes that previously investigated. Methods...
Objective Methotrexate (MTX) is the drug of first choice for treatment rheumatoid arthritis (RA), but effective only in around 60% patients. Identification genetic markers to predict response essential within a critical window period 6 months after diagnosis, have been hitherto elusive. In this study, we used genome-wide genotype data identify potential risk variants associated with MTX (poor)response north Indian RA cohort. Materials and methods Genome-wide genotyping total 457 patients...
Tumor necrosis factor alpha (TNF-α) is the major cause of inflammation in autoimmune diseases like rheumatoid arthritis (RA). It's mechanisms signal transduction through nuclear kappa B (NF-kB) pathway via small molecules such as metabolite crosstalk are still elusive. In this study, we have targeted TNF-α and NF-kB metabolites RA, to inhibit activity deter signaling pathways, thereby mitigating disease severity RA. structure was obtained from PDB database RA were selected literature survey....
Genome-wide association studies (GWAS) and their subsequent meta-analyses have changed the landscape of genetics in rheumatoid arthritis (RA) by uncovering several novel genes. Such are heavily weighted samples from Caucasian populations, but they explain only a small proportion total heritability. Our previous genetically distinct North Indian RA cohorts demonstrated apparent allelic/genetic heterogeneity between Western warranting GWAS non-European populations. We undertook this study to...
Methotrexate (MTX) is the drug of choice for rheumatoid arthritis (RA) but effective only in around 60% treated patients. Bioavailability MTX may be a major determinant response status and this governed by variations receptor transporter genes responsible polyglutamation deconjugation. We investigated contribution single nucleotide polymorphisms (SNPs) RFC, FOLR1, FPGS, GGH MDR1 to RA patients from North India.RA recruited using American College Rheumatology criteria, were categorized into...
Purpose of the Study: The present study was undertaken to evaluate diagnostic utility fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (F-18 FDG PET/CT) in patients presenting as pyrexia unknown origin (PUO). Materials and Methods: Forty-seven (31 males 16 females; mean age 42.7 ± 19.96 years) PUO Department Medicine at All India Institute Medical Sciences, New Delhi over a period 2 years underwent F-18 PET/CT. PET ⁄ CT considered supportive when its results...
Cerebral malaria is a major health hazard, with high incidence of mortality. The disease endemic in many developing countries, but greater increase tourism, occasional cases may be detected countries where the not prevalent. Early diagnosis and evaluation cerebral involvement utilizing modern imaging modalities have an impact on treatment clinical outcome.To evaluate magnetic resonance (MR) features patients presenting altered sensorium.We present findings three sensorium. MR using 1.5-Tesla...
Rheumatoid arthritis (RA) is one of the most common chronic inflammatory autoimmune diseases, which adversely affects quality life. RA a disease unknown etiology, however, both genetic and environmental factors appear to contribute susceptibility this disease. The severity progression are attributable release host cytokines, cytotoxic immune regulatory factors. treatments primarily limited symptomatic alleviation pain or other symptoms use drug treatment in severe forms commonly associated...