A5101662178- Glaucoma and retinal disorders
- Reproductive System and Pregnancy
- Sperm and Testicular Function
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Mindfulness and Compassion Interventions
- Retinal Imaging and Analysis
- Retinal Diseases and Treatments
- Reproductive Biology and Fertility
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Urological Disorders and Treatments
- Ocular Oncology and Treatments
- Inflammasome and immune disorders
- S100 Proteins and Annexins
- Sexual Differentiation and Disorders
- Signaling Pathways in Disease
- Ocular Surface and Contact Lens
- Fluoride Effects and Removal
- Mitochondrial Function and Pathology
- Infant Nutrition and Health
- Neuropeptides and Animal Physiology
- Cardiac Health and Mental Health
- Corneal Surgery and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cancer-related Molecular Pathways
All India Institute of Medical Sciences
2011-2025
Manipal Hospital
2024
Sawai ManSingh Medical College and Hospital
2024
All India Institute of Medical Sciences Bhubaneswar
2020
Keele University
2018
Objectives Hypospermatogenesis (HS) is a common histopathological subtype of non-obstructive azoospermia (NOA), characterized by decrease in the total number germ cells within seminiferous tubule. The diagnosis HS made invasive procedures like testicular biopsy or fine needle aspiration (FNA). MicroRNAs (miRs) are biomolecules with emerging roles as diagnostic biomarkers for diseases. This study aimed to investigate differential miR expression profile idiopathic (iHS) explore candidate...
Various external stressors and environmental challenges lead to the provocation of immune system in autoimmune diseases like Rheumatoid arthritis (RA). The inappropriate response further triggers cascade inflammatory changes resulting precipitation symptoms hampers quality life (QOL). underlying psycho-somatic component disease requires a holistic approach its treatment dimension rather than use pharmacotherapy. applicability mind-body interventions has become essential today's fast-paced...
Hypospermatogenesis is a common histopathological subtype of non-obstructive azoospermia and characterized by decrease in the total number germ cells within seminiferous tubule as result spermatogenic failure. Determination genetic factors before intracytoplasmic sperm injection can prevent inheritance these factors, hypospermatogenesis patients gives high successful retrieval rate. This study aimed to identify structural variants associated with idiopathic (iHS) analyzing patient cohorts...
Recurrent pregnancy loss (RPL) is one of the devastating complications and current focus lies in addressing management paternal factors. Dysregulation selective transcripts delivered to oocyte at fertilization can result losses adversely affect embryogenesis. The objective this study was assess effect yoga-based lifestyle intervention (YBLI) on seminal oxidative stress (OS), DNA damage spermatozoal transcript levels.The present a part prospective ongoing exploratory 30 male partners couples...
A series of thiazolopyrimidine derivatives was designed, synthesized and screened for in-vitro inhibition Dipeptidyl Peptidase IV (DPP IV). The SAR study indicated the influence substituted chemical modifications on scaffold. Compound 9 (IC(50) = 0.489 μm) 10 0.329 having heterocyclic-substituted piperazine with acetamide linker resulted as most potent DPP inhibitors among all compounds screened. Single dose (10 mg/kg) both significantly reduced glucose excursion during oral tolerance test...
Hypertrophic Cardiomyopathy (HCM) is an autosomal dominant disorder of the myocardium which hypertrophied resulting in arrhythmias and heart failure leading to sudden cardiac death (SCD). Several sarcomeric proteins modifier genes have been implicated this disease. Troponin I, being a part complex (troponin troponin C, T), important gene for function. Four mutations (1 novel) were identified Indian HCM cases, namely, Pro82Ser, Arg98Gln, Arg141Gln Arg162Gln I protein, are functionally...
SUMMARY Obesity and depression are conditions that have been linked through a great number of interesting mechanisms. To fully understand the implications treatment choices it is necessary to continue investigate physiology these two conditions. By examining background problems considering factors such as stress response, neurological change systemic inflammation, we propose cycle linking obesity. With reference this cycle, discuss management options, focusing particularly on prescribing...
Abstract Glycogen storage disease type III (GSD III) is a rare autosomal recessive inborn error of glycogen degradation pathway due to deficiency or reduced activity debranching enzyme (GDE) that results in accumulation abnormal the liver, muscle, and heart. The cardinal hallmarks are hepatomegaly, fasting hypoglycemia, seizures, growth retardation, progressive skeletal myopathy, cardiomyopathy few. To date, 258 mutations amyloglucosidase ( AGL ) gene have been identified worldwide. However,...
Purpose: To evaluate changes in anterior segment morphology following laser peripheral iridotomy (LPI) and trabeculectomy primary angle closure glaucoma (PACG) using Sirius Scheimpug imaging. Methods: In this prospective study, PACG patients undergoing LPI were imaged pre- post-procedure the system. Anterior parameters including chamber depth (ACD), volume (ACV), (ACA), iris curvature (I-Curv), lens vault (LV) analyzed compared. Results: 72 eyes of 36 analyzed. At 1 month post-LPI, there...
Introduction This study aimed to evaluate the efcacy of adding 0.1% nepafenac ophthalmic suspension a topical steroid regimen after uncomplicated cataract surgery in reducing additional inammatory manifestations and subclinical macular edema. Methodology randomized controlled interventional took place at an upgraded Department Ophthalmology within tertiary care facility Jaipur. Data collection occurred from June October 2023, with two months for analysis. The included patients senile...
Background Retinoblastoma (RB) is initiated by mutation in both alleles of RB1 gene. However, few cases may occur even the absence suggesting role genes other than RB1.Methodology The current study was planned to utilize targeted exome sequencing Indian RB patients affected with unilateral non-familial RB. 75 below 5 years age were enrolled. Genomic DNA extracted from blood and tumor tissue. From peripheral DNA, all coding exon/intron regions amplified using PCR direct sequencing. Cases...
Abstract Hypospermatogenesis (HS) is among the most prevalent histopathological subtype of primary testicular failure and characterized by a decrease in total number germ cells within seminiferous tubules, leading to azoospermia or oligospermia. Spermatozoa retrieval for intracytoplasmic sperm injection hypospermatogenesis cases has high success rate, but there risk that progeny will inherit genomic epigenetic causative factors. A multifactorial etiology associated with all subtypes failure,...