Cu(II) complexes of three tridentate ligands, L1, L2 and L3,[ N-((1H-imidazole-2-yl)methyl)-2-(pyridine-2-yl)ethanamine; L2, N-((1-methyl-1H-imidazole-2-yl)methyl)-2-(pyridine-2-yl)ethanamine; L3, 2-(pyridine-2-yl)-N-((pyridine-2-yl)methyl)ethanamine] respectively, were synthesized characterized. The single crystal X-ray structure complex 1 reveals the pseudo octahedral coordination geometry around copper center. Absorption fluorescence experimental evidence show good DNA binding propensity...

Fluoride is a naturally occurring element that plays significant role in the environment and serves as an essential trace living organisms. It present various environmental components, including air, water, soil, plants, animals, due to both natural processes anthropogenic activities. Extended exposure fluoride animals can result toxicity, leading adverse health outcomes onset of fluorosis. This condition predominantly affects dental skeletal structures, potentially causing deformities. In...

Abstract Background: Diabetic nephropathy (DN) occurs due to angiopathy of glomerular capillaries, which alters the compliance and resistance vessel wall. This can be measured with renal resistive index (RI) using Doppler, indicating disease progression. Aims Objectives: study aimed assess utility RI in type 2 diabetes mellitus association between DN other complications. Materials Methods: One hundred diabetic patients, 50 each without nephropathy, alongside nondiabetics (controls) were...

The quenched fluorescent intensity of a copper(II) complex, 1, ligand, in degassed methanol or aqueous (buffered at pH 7.2) solution, was found to reappear on exposure nitric oxide. Thus, it can function as fluorescence based oxide sensor. It has been that the present complex be used sense nanomolar quantities both and 7.2 buffered-water medium.

Summary. Influenza virus infection, induced experimentally in mice, was associated with marked changes lung morphology viz. epithelial damage focal areas of reactive papillary hyperplasia, infiltration leukocytes and development oxidative stress, as evidenced by increased superoxide radical production lipid peroxidation (LPO) products alveolar macrophages. These effects were observed on the 5th day after instillation. The levels LPO measured spectrophotometrically nitroblue tetrazolium (NBT)...

In the mice, instillation of influenza virus A/Udorn/317/72(H3N2) intranasally resulted in a significant decrease pulmonary concentrations catalase, reduced glutathione, and superoxide dismutase. There was vitamin E level also. These effects were observed on 5th day after viral instillation. Oral supplementation with quercetin simultaneous produced increases However, did not reverse fall associated infection. It is concluded that during infection, there "oxidative stress." Because restored...

Thuja orientalis (Commonly- Morpankhi, Family- Cupressaceae) is an evergreen, monoecious trees or shrubs used in various forms of traditional medicines and homeopathy ways. In practices for treatment bronchial catarrh, enuresis, cystitis, psoriasis, uterine carcinomas, amenorrhea rheumatism. Recent re- searches different parts the world have shown that T. its active component thujone great poten- tial against a health problems. preparations can be efficiently microbial/worm infection. It as...

A μ-oxo diiron complex, featuring the pyridine-2,6-dicarboxamide-based thiazoline-derived redox-active ligand, H

Leptospira interrogans serovar Copenhageni strain Fiocruz L1-130 carries a set of cas genes associated with CRISPR-Cas subtype I-B. Herein, we report for the first time active transcription (cas1 to cas8) L. where cas4, cas1, cas2 and cas6, cas3, cas8, cas7, cas5 are clustered together in two independent operons. As an initial step toward comprehensive understanding system spirochete, biochemical study one core Cas2 proteins (Lep_Cas2) showed nuclease activity on both DNA RNA nonspecific...

The roles of cellular proteases in Moloney murine leukemia virus (MLV) infection were investigated using MLV particles pseudotyped with vesicular stomatitis (VSV) G glycoprotein as a control for effects on core versus specific to envelope protein (Env). broad-spectrum inhibitors cathepsin inhibitor III and E-64d gave comparable dose-dependent inhibition Env VSV pseudotypes, suggesting that the decrease did not involve protein. Whereas, CA-074 Me biphasic response differentiated between at...

The present study was conducted to investigate the effect of dietary supplementation zinc (Zn) and selenium (Se) on antioxidative status testosterone, T4 T3 levels in 12 bucks aged between 2 4 years, weighing 25–35 kg. experimental animals were divided control test groups containing six each. group not given any supplementation, whereas Zn Se form 150-ppm sulphate 0.50-ppm sodium selenite, respectively, for 105 days. serum seminal plasma, plasma estimated at 0, 60, 75, 90 days experiment....

The nitric oxide reactivity of two copper(II) complexes, 1 and 2 with ligands L1 L2, respectively, [L1 = 5,5,7,12,12,14-hexamethyl-1,4,8,11-tetraazacyclotetradecane, L2 5,5,7-trimethyl-[1,4]-diazepane] have been studied. center in complex was found to be unreactive toward pure acetonitrile; however, it displayed reduction methanol solvent presence base. 2, acetonitrile solvent, on exposure has reduced copper(I). same observed methanol, also, case 2. In 1, presumably, the attack deprotonated...

Background: Apicomplexan parasite Theileria annulata causes significant economic loss to the livestock industry in India and other tropical countries. In India, control is mainly dependent on live attenuated schizont vaccine drug buparvaquone. For effective disease control, it essential study population structure genetic diversity of field isolates currently used India. Methodology/Results: A total 125 T. were genotyped using 10 microsatellite markers from four states belonging different...