A5077028241- Medical Imaging Techniques and Applications
- RNA and protein synthesis mechanisms
- Radiopharmaceutical Chemistry and Applications
- RNA modifications and cancer
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging and Pathology Studies
- Cardiac Imaging and Diagnostics
- Neuroendocrine Tumor Research Advances
- Neuroblastoma Research and Treatments
- Glioma Diagnosis and Treatment
- Bacterial Genetics and Biotechnology
- RNA Research and Splicing
- DNA and Nucleic Acid Chemistry
- Orthopedic Infections and Treatments
- Cancer, Hypoxia, and Metabolism
- Bacteriophages and microbial interactions
- Lung Cancer Research Studies
- Pediatric Urology and Nephrology Studies
- Adrenal and Paraganglionic Tumors
- Advanced X-ray and CT Imaging
- Hematological disorders and diagnostics
- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Cancer Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
AstraZeneca (United States)
2024
University of Miami
2012-2021
All India Institute of Medical Sciences
2008-2018
Delhi State Cancer Institute
2017
Dr. Ram Manohar Lohia Institute of Medical Sciences
2015
Wadsworth Center
1998-2014
DR. B.R.A. Institute Rotary Cancer Hospital
2011-2013
All India Institute of Medical Sciences Bhopal
2000-2011
All India Institute of Medical Sciences Raipur
2000-2011
Voluntary Health Association Of India
2011
Besides linear RNAs, pre-mRNA splicing generates three forms of RNAs: lariat introns, Y-structure introns from trans-splicing, and circular exons through exon skipping. To study the persistence excised in total cellular RNA, we used Escherichia coli 3' to 5' exoribonucleases. Ribonuclease R (RNase R) thoroughly degrades abundant RNAs while preserving loop portion a RNA. II II) polynucleotide phosphorylase (PNPase) also preserve loop, but are less efficient degrading RNAs. RNase digestion RNA...
The path of the nucleic acids through a transcription elongation complex was tracked by mapping cross-links between bacterial RNA polymerase (RNAP) and transcript or template DNA onto x-ray crystal structure. In resulting model, downstream duplex is nestled in trough formed β′ subunit enclosed on top β subunit. RNAP channel, RNA/DNA hybrid extends from enzyme active site, along region harboring rifampicin resistance mutations, to “rudder.” single-stranded then extruded another channel...
Objective The correct diagnosis of tumor thrombosis and its differentiation from benign thrombus can change patient management prevent unnecessary anticoagulation treatment. This study was aimed at evaluating the role fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET-CT) in thrombosis, thromboembolism. Methods We conducted a retrospective review FDG PET-CT scans patients who underwent for staging/restaging known malignancy had FDG-avid thrombosis. Maximum...
RNase II, a 3′ to 5′ processive exoribonuclease, is the major hydrolytic enzyme in Escherichia coli accounting for ∼90% of total activity. Despite its importance, little actually known about regulation this enzyme. We show here that one residue, Lys501, acetylated II. This modification, reversibly controlled by acetyltransferase Pka, and deacetylase CobB, affects binding substrate thus decreases catalytic activity As consequence, steady-state level target RNAs II may be altered cells. also...
The purpose of this study was to evaluate the role (68)Ga-labeled DOTANOC PET/CT for baseline evaluation patients with head and neck paragangliomas (HNPs).The data 26 (mean age ± SD, 34.3 10.4 y; 50% men) known or suspected HNPs who underwent (68)Ga-DOTANOC staging were retrospectively analyzed. performed after intravenous injection 132-222 MBq (68)Ga-DOTANOC. images evaluated by 2 experienced nuclear medicine physicians in consensus, both qualitatively quantitatively. findings grouped as...
This study aimed to compare the diagnostic performance of Ga-DOTANOC PET/CT with F-FDG in patients gastroenteropancreatic neuroendocrine tumors (GEP-NETs).Data 51 definite histological diagnosis GEP-NET who underwent both Ga-DOTA-NOC PET-CT and within a span 15 days were selected for this retrospective analysis. Sensitivity, specificity, predictive values calculated PET-CT, results compared on patientwise regionwise analysis.Ga-DOTA-NOC is superior analysis (P < 0.0001). On analysis, only...