A5086437823- Malaria Research and Control
- Mosquito-borne diseases and control
- Reproductive tract infections research
- Potassium and Related Disorders
- Adolescent Sexual and Reproductive Health
- COVID-19 epidemiological studies
- Syphilis Diagnosis and Treatment
- Child Nutrition and Water Access
- Parasites and Host Interactions
- Gestational Diabetes Research and Management
- Invertebrate Immune Response Mechanisms
- Pregnancy and preeclampsia studies
- Survey Sampling and Estimation Techniques
- Criminal Justice and Corrections Analysis
- Vibrio bacteria research studies
- Global Maternal and Child Health
- Vaccine Coverage and Hesitancy
- Computational Drug Discovery Methods
- Substance Abuse Treatment and Outcomes
- SARS-CoV-2 and COVID-19 Research
- HIV, Drug Use, Sexual Risk
- Regional Development and Policy
- Electrolyte and hormonal disorders
- HIV-related health complications and treatments
- Bacterial Infections and Vaccines
Harvard University
2023-2024
Analysis Group (United States)
2024
Boston University
2024
Group Health Cooperative
2024
Center for Disease Dynamics, Economics & Policy
2022
University of North Carolina at Chapel Hill
2020-2021
Program for Appropriate Technology in Health
2020
University of Massachusetts Boston
2017
In Africa, most rapid diagnostic tests (RDTs) for falciparum malaria recognize histidine-rich protein 2 antigen. Plasmodium parasites lacking (pfhrp2) and 3 (pfhrp3) genes escape detection by these RDTs, but it is not known whether deletions confer sufficient selective advantage to drive population expansion. By studying blood samples from a cohort of 12,572 participants enroled in prospective, cross-sectional survey along Ethiopia's borders with Eritrea, Sudan South using PCR, an...
Abstract Diagnosis and treatment of Plasmodium falciparum infections are required for effective malaria control pre-requisites elimination efforts; hence we need to monitor emergence, evolution spread drug- diagnostics-resistant parasites. We deep sequenced key drug-resistance mutations 1,832 SNPs in the parasite genomes 609 cases collected during a diagnostic-resistance surveillance study Ethiopia. found that 8.0% (95% CI 7.0–9.0) were caused by P. carrying candidate artemisinin...
Abstract Background Doxycycline post-exposure prophylaxis (DoxyPEP) has demonstrated efficacy for prevention of bacterial sexually transmitted infections. To inform policy decisions on the use DoxyPEP gonorrhea prevention, we used a mathematical model to investigate its impact resistance dynamics and burden infection in men who have sex with (MSM). Methods Findings Using deterministic compartmental transmission an MSM population, introduced at various uptake levels (10-75%) compared 20-year...
Abstract Background The recent expansion of tools designed to accurately quantify malaria parasite-produced antigens has enabled us evaluate the performance rapid diagnostic tests (RDTs) as a function they detect—typically histidine rich protein 2 (HRP2) or lactate dehydrogenase (LDH). Methods For this analysis, whole blood specimens from longitudinal study in Bancoumana, Mali were used ultra-sensitive HRP2-based Alere™ Malaria Ag P.f RDT (uRDT). samples collected part transmission-blocking...
Abstract Background Gonorrhea is a highly prevalent sexually transmitted infection and an urgent public health concern due to increasing antibiotic resistance. Only ceftriaxone remains as the recommended treatment in U.S. The prospect of approval new anti-gonococcal antibiotics raises question how deploy drug maximize its clinically useful lifespan. Methods We used compartmental model gonorrhea transmission population men who have sex with compare strategies for introducing treatment. tested...
Abstract The emergence and spread of drug- diagnostic-resistant Plasmodium falciparum are major impediments to malaria control elimination. We deep sequenced known drug resistance mutations other informative loci across the genome 609 samples collected during a study three regions Ethiopia. found that 8.0% (95% CI 7.0-9.0) cases were caused by P. carrying candidate artemisinin partial-resistance K13 622I mutation, which occurred less commonly in pfhrp2/3- deleted than normal non-deleted...
Abstract Background and Aims Hyperkalaemia is associated with increased healthcare resource use often requires long-term management. The GALVANIZE Outcomes study a comparison of hyperkalaemia-related all-cause hospitalisations or emergency department visits between matched patients treated long- short-term sodium zirconium cyclosilicate (SZC), using real-world data. This analysis evaluated outcomes in history hyperkalaemia. Method A large US insurance claims database (from HealthVerity) was...
Introduction: Patients receiving renin-angiotensin-aldosterone system inhibitors (RAASi) are at increased risk of developing hyperkalemia (HK). Sodium zirconium cyclosilicate (SZC) is used to treat HK, but the impact duration SZC on healthcare resource utilization (HRU) in RAASi users unknown. The GALVANIZE Outcome study compared HK-related HRU among between long-term and short-term users. Methods: Adults with ≥1 outpatient prescription for (index date) spanning index date were identified...
To bridge a gap in access to community services for releasing state inmates, the Boston Offender Needs Delivery (BOND) project was developed as longitudinal study (2014-2016) of adult inmates with history substance use and co-occurring mental health disorders returning following detention one Massachusetts' State correctional facilities. Pre-release who were wrapping up their sentence (i.e., no supervision) presented illness and/or disorder recruited. Participants provided abuse treatment...
Abstract Malaria diagnostic testing in Africa is threatened by Plasmodium falciparum parasites lacking histidine-rich protein 2 ( pfhrp2 ) and 3 pfhrp3 genes. Among 12,572 subjects enrolled along Ethiopia’s borders with Eritrea, Sudan, South Sudan using multiple assays, we estimate HRP2-based rapid tests would miss 9.7% (95% CI 8.5-11.1) of malaria cases due to deletion. Established novel genomic tools reveal distinct subtelomeric deletion patterns, well-established deletions, recent...
Background: Assessment of disease severity associated with a novel pathogen or variant provides critical information needed by public health agencies and governments to develop appropriate responses. The SARS-CoV-2 Omicron Variant Concern (VOC) spread rapidly through populations worldwide before robust epidemiological laboratory data were available investigate its relative severity. Here we set methods that make use non-linked, aggregate answer questions dynamics.Methods: Using from the...