A5031835550- Reproductive tract infections research
- Syphilis Diagnosis and Treatment
- Adolescent Sexual and Reproductive Health
- Cervical Cancer and HPV Research
- HIV/AIDS Research and Interventions
- HIV, TB, and STIs Epidemiology
- COVID-19 epidemiological studies
- Reproductive Health and Contraception
- HIV, Drug Use, Sexual Risk
- Bacterial Infections and Vaccines
- Sex work and related issues
- Urinary Tract Infections Management
- Hepatitis B Virus Studies
- Genital Health and Disease
- Global Cancer Incidence and Screening
- Colorectal Cancer Screening and Detection
- T-cell and Retrovirus Studies
- Vaccine Coverage and Hesitancy
- HIV Research and Treatment
- COVID-19 and Mental Health
- Data-Driven Disease Surveillance
- Parvovirus B19 Infection Studies
- Female Genital Mutilation/Cutting Issues
- Statistical Methods and Bayesian Inference
- Autoimmune Bullous Skin Diseases
Harvard Global Health Institute
2018-2024
Harvard University
2017-2024
Massachusetts Department of Public Health
2017-2024
Centers for Disease Control and Prevention
2024
Stanford University
2024
Public Health Department
2021
Imperial College London
2010-2019
Boston University
2018-2019
Medical Research Council
2013
National Institute for Health Research
2013
Significance The US COVID-19 Trends and Impact Survey (CTIS) has operated continuously since April 6, 2020, collecting over 20 million responses. As the largest public health survey conducted in United States to date, CTIS was designed facilitate detailed demographic geographic analyses, track trends time, accommodate rapid revision address emerging priorities. Using examples of results illuminating symptoms, risks, mitigating behaviors, testing, vaccination relation evolving high-priority...
In 2020, the World Health Organization (WHO) launched its initiative to eliminate cervical cancer as a public health problem. To inform global efforts for countries with high HIV and burden, we assessed impact of human papillomavirus (HPV) vaccination screening treatment in South Africa, on potential achieving elimination before 2120, considering faster HPV disease progression higher risk among women living HIV(WLHIV) interventions.
Abstract Background Comprehensive evaluation of the quality-adjusted life-years (QALYs) lost attributable to chlamydia, gonorrhea, andtrichomoniasis in United States is lacking. Methods We adapted a previous probability-tree model estimate average number lifetime QALYs due genital and trichomoniasis, per incident infection at population level, by sex age group. conducted multivariate sensitivity analyses address uncertainty around key parameter values. Results The estimated total discounted...
Abstract Background Point-of-care testing (POCT) assays for chlamydia are being developed. Their potential impact on the burden of chlamydial infection in United States, light suboptimal screening coverage, remains unclear. Methods Using a transmission model calibrated to data we estimated POCT prevalence, incidence, and chlamydia-attributable pelvic inflammatory disease (PID) assuming status quo (Analysis 1) improved 2) frequencies. We tested robustness results changes sensitivity,...
Abstract The U.S. COVID-19 Trends and Impact Survey (CTIS) is a large, cross-sectional, Internet-based survey that has operated continuously since April 6, 2020. By inviting random sample of Facebook active users each day, CTIS collects information about symptoms, risks, mitigating behaviors, mental health, testing, vaccination, other key priorities. large scale the – over 20 million responses in its first year operation allows tracking trends short timescales comparisons at fine demographic...
Population-level effects of control strategies on the dynamics Chlamydia trachomatis transmission are difficult to quantify. In this study, we calibrated a novel sex- and age-stratified pair-formation model chlamydial infection epidemiologic data in United States for 2000-2015. We used age-specific prevalence estimates from National Health Nutrition Examination Surveys, case report national chlamydia surveillance, survey Youth Risk Behavior Survey proportion sexually active population aged...
Background Men who have sex with men (MSM) are disproportionately burdened by gonorrhea and face high rates of extragenital (rectal pharyngeal) infection, which is mostly asymptomatic often missed urogenital-only screening. Extragenital screening likely remains below Centers for Disease Control Prevention–recommended levels. Because increasing coverage resource-intensive, we assessed whether improved among already presenting at clinics could lead to substantial reductions in prevalence...
<h3>Objectives</h3> A number of individuals have acquired lymphogranuloma venereum (LGV) infection multiple times since its re-emergence. We describe the characteristics reinfections and those who acquire them. <h3>Methods</h3> The LGV Enhanced Surveillance system collected detailed information on episodes in UK from 2004 to 2010. Using logistic regression we compared baseline men sex with (MSM) had a repeat episode ('repeaters') MSM single reported ('non-repeaters'). <h3>Results</h3> There...
Background The burden of gonorrhea infections in the United States is high. There are marked disparities by race/ethnicity and sexual orientation. We quantified impact screening treatment on rates US population aged 15 to 39 years for period 2000 2015 estimated that alternative strategies might have had over same period. Methods developed a national-level transmission model divides race/ethnicity, preferred gender sex partners, age, gender, activity level. compared our fitted (“base case”) 4...
The COVID-19 pandemic indirectly impacts HIV epidemiology in Central/West Africa. We estimated the potential impact of COVID-19-related disruptions to prevention/treatment services and sexual partnerships on incidence HIV-related deaths among key populations including female sex workers (FSW), their clients, men who have with men, overall.Yaoundé (Cameroon) Cotonou (Benin).We used mathematical models calibrated city population-specific risk demographic/behavioral/epidemic data. relative...
Abstract Background The purpose of this study was to estimate the health impact syphilis in United States terms number quality-adjusted life years (QALYs) lost attributable infections 2018. Methods We developed a Markov model that simulates natural history and management syphilis. parameterized by sex sexual orientation (women who have with men, men women [MSW], [MSM]), age at primary infection. separate decision tree quantify losses due congenital estimated average lifetime QALYs per...
Chlamydia remains a significant public health problem that contributes to adverse reproductive outcomes. In the United States, sexually active women 24 years and younger are recommended receive annual screening for chlamydia. this study, we evaluated impact of estimated current levels partner notification (PN), based on guidelines chlamydia associated sequelae, quality adjusted life (QALYs) lost costs.We conducted cost-effectiveness analysis screening, using published calibrated pair...
Abstract Rapid point-of-care tests that diagnose gonococcal infections and identify susceptibility to antibiotics enable individualized treatment. This could improve patient outcomes slow the emergence spread of antibiotic resistance. However, little is known about long-term impact such diagnostics on burden gonorrhea effective life span antibiotics. We used a mathematical model transmission among men who have sex with in United States project annual rate reported cases ceftriaxone,...
Background Since common diagnostic tests for gonorrhea do not provide information about susceptibility to antibiotics, treatment of remains empiric. Antibiotics used empiric therapy are usually changed once resistance prevalence exceeds a certain threshold (e.g., 5%). A low switch is intended increase the probability that an infection successfully treated with first-line antibiotic, but it could also pace at which recommendations switched newer antibiotics. Little known impact changing on...
Background The current syphilis epidemic in the United States is concentrated gay, bisexual, and other men who have sex with (MSM), but substantial heterosexual transmission reported some parts of country. Using US states Louisiana Massachusetts as case studies, we investigated how context influences impact population screening approaches for control. Methods We constructed a compartmental metapopulation model parameterized to describe observed patterns transmission. estimated different...