Michael Wittig
A5012645304- Helicobacter pylori-related gastroenterology studies
- Genetic Associations and Epidemiology
- Digestive system and related health
- Genomic variations and chromosomal abnormalities
- Inflammatory Bowel Disease
- Epigenetics and DNA Methylation
- Genomics and Rare Diseases
- Genetic and phenotypic traits in livestock
- Genetics and Neurodevelopmental Disorders
- Blood groups and transfusion
- COVID-19 Clinical Research Studies
- Genetic Mapping and Diversity in Plants and Animals
- Hemoglobinopathies and Related Disorders
- RNA modifications and cancer
- T-cell and B-cell Immunology
- SARS-CoV-2 and COVID-19 Research
- Genetic diversity and population structure
- Alzheimer's disease research and treatments
- Erythrocyte Function and Pathophysiology
- Dementia and Cognitive Impairment Research
- Acute Lymphoblastic Leukemia research
- RNA regulation and disease
- RNA and protein synthesis mechanisms
- Chronic Myeloid Leukemia Treatments
- Liver Disease Diagnosis and Treatment
Kiel University
2014-2024
Harvard University
2023
Clinical Research Center Kiel
2009-2021
Biogipuzkoa Health Research Institute
2020
Brigham and Women's Hospital
2012
University Hospital Schleswig-Holstein
2009-2011
University of Lübeck
2009-2011
Medical University of Vienna
2009
Max Delbrück Center
2009
University of Cologne
2009
There is considerable variation in disease behavior among patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes 2019 (Covid-19). Genomewide association analysis may allow for identification of potential genetic factors involved development Covid-19.
Although single base-pair substitutions in splice junctions constitute at least 10% of all mutations causing human inherited disease, the factors that determine their phenotypic consequences RNA level remain to be fully elucidated. Employing a neural network for splice-site recognition, we performed meta-analysis 478 disease-associated splicing mutations, 38 different genes, which detailed laboratory-based mRNA phenotype assessment had been performed. Inspection +/-50-bp DNA sequence context...
Microdeletion at chromosomal position 15q13.3 has been described in intellectual disability, autism spectrum disorders, schizophrenia and recently idiopathic generalized epilepsy (IGE). Using independent IGE cohorts, we first aimed to confirm the association of deletions IGE. We then set out determine relative occurrence sporadic familial cases examine likelihood having seizures for individuals with microdeletion cases. The was identified 7 539 (1.3%) unrelated using quantitative PCR or SNP...
Crohn disease (CD), a sub-entity of inflammatory bowel (IBD), is complex polygenic disorder. Although recent studies have successfully identified CD-associated genetic variants, these susceptibility loci explain only fraction the heritability disease. Here, we report on multi-stage genome-wide scan 393 German CD cases and 399 controls. Among 116,161 single-nucleotide polymorphisms tested, an association with known gene NOD2, 5q31 haplotype, recently reported locus at 5p13.1 was confirmed. In...
ABSTRACT Background Respiratory failure is a key feature of severe Covid-19 and critical driver mortality, but for reasons poorly defined affects less than 10% SARS-CoV-2 infected patients. Methods We included 1,980 patients with respiratory at seven centers in the Italian Spanish epicenters pandemic Europe (Milan, Monza, Madrid, San Sebastian Barcelona) genome-wide association analysis. After quality control exclusion population outliers, 835 1,255 population-derived controls from Italy,...
Abstract Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder and common form of dementia in elderly. Susceptibility to AD considerably determined by genetic factors which hitherto were primarily identified using case–control designs. Elucidating architecture additional AD-related phenotypic traits, ideally those linked underlying process, holds great promise gaining deeper insights into basis developing better clinical prediction models. To this end, we generated...
Because transethnic analysis may facilitate prioritization of causal genetic variants, we performed a genomewide association study (GWAS) psoriasis in South Asians (SAS), consisting 2,590 cases and 1,720 controls. Comparison with our existing European-origin (EUR) GWAS showed that effect sizes known signals were highly correlated SAS EUR (Spearman ρ = 0.78;
Alzheimer’s disease (AD) is the most frequent neurodegenerative with an increasing prevalence in industrialized, aging populations. AD susceptibility has established genetic basis which been focus of a large number genome-wide association studies (GWAS) published over last decade. Most these GWAS used dichotomized clinical diagnostic status, i.e., case vs. control classification, as outcome phenotypes, without use biomarkers. An alternative and potentially more powerful study design afforded...
Rolandic epilepsy (RE) is the most common idiopathic focal childhood epilepsy.Its molecular basis largely unknown and a complex genetic etiology assumed in majority of affected individuals.The present study tested whether six large recurrent copy number variants at 1q21, 15q11.2,15q13.3,16p11.2,16p13.
Inversion polymorphisms constitute an evolutionary puzzle: they should increase embryo mortality in heterokaryotypic individuals but still are widespread some taxa. Some insect species have evolved mechanisms to reduce the cost of humans not. In birds, a detailed analysis is missing although intraspecific inversion regarded as common. Australian zebra finches (Taeniopygia guttata), two polymorphic inversions known cytogenetically and we set out detect these potentially additional using...
Genotype imputation of the human leukocyte antigen (HLA) region is a cost-effective means to infer classical HLA alleles from inexpensive and dense SNP array data. In research setting, helps avoid costs for wet lab-based typing thus renders association analyses in large cohorts feasible. Yet, most reference panels target Caucasian ethnicities multi-ethnic are scarce. We compiled high-quality panel based on genotypes measured with Illumina's Immunochip genotyping types established using...
Abstract Introduction Neurofilament light (NfL), chitinase‐3‐like protein 1 (YKL‐40), and neurogranin (Ng) are biomarkers for Alzheimer's disease (AD) to monitor axonal damage, astroglial activation, synaptic degeneration, respectively. Methods We performed genome‐wide association studies (GWAS) using DNA cerebrospinal fluid (CSF) samples from the EMIF‐AD Multimodal Biomarker Discovery study discovery, Disease Neuroimaging Initiative validation analyses. GWAS were all three CSF linear...
Objective Haemorrhoidal disease (HEM) affects a large and silently suffering fraction of the population but its aetiology, including suspected genetic predisposition, is poorly understood. We report first genome-wide association study (GWAS) meta-analysis to identify risk factors for HEM date. Design conducted GWAS 218 920 patients with 725 213 controls European ancestry. Using summary statistics, we performed multiple correlation analyses between other traits as well calculated polygenic...
The executive function of shifting between mental sets demands cognitive flexibility. Based on evidence that physical exercise fostered cognition, we tested whether acute can improve in an unselected sample adolescents. Genetic polymorphisms were analyzed to gain more insight into possibly contributing neurophysiological processes. We examined 297 students aged 13 and 17 years their schools. Physical was manipulated by intense incremental condition using bicycle ergometers a control which...