Robert Markewitz
A5052669009- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- German Literature and Culture Studies
- Peripheral Neuropathies and Disorders
- Public Administration and Political Analysis
- SARS-CoV-2 detection and testing
- Medical Practices and Rehabilitation
- Autoimmune Neurological Disorders and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Diabetes and associated disorders
- Herpesvirus Infections and Treatments
- Hematological disorders and diagnostics
- Advanced Memory and Neural Computing
- Health and Medical Studies
- Platelet Disorders and Treatments
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Long-Term Effects of COVID-19
- Neural dynamics and brain function
- Medical and Health Sciences Research
- Biomedical and Chemical Research
- Multiple and Secondary Primary Cancers
- interferon and immune responses
- Transcranial Magnetic Stimulation Studies
- Infant Health and Development
University Hospital Schleswig-Holstein
2020-2025
University of Lübeck
2020-2025
Clinical Research Center Kiel
2024
Ludwig-Maximilians-Universität München
2021
Jena University Hospital
2021
Klinikum Ludwigshafen
2021
University of Regensburg
2015-2018
In light of the SARS-CoV-2 pandemic, protecting vulnerable groups has become a high priority. Persons at risk severe disease, for example, those receiving immunosuppressive therapies chronic inflammatory cdiseases (CIDs), are prioritised vaccination. However, data concerning generation protective antibody titres in immunosuppressed patients scarce. Additionally, mRNA vaccines represent new vaccine technology leading to increased insecurity especially with CID.Here we present first time, on...
<h3>Background and Objectives</h3> To determine the real-world use of rituximab in autoimmune encephalitis (AE) to correlate treatment with long-term outcome. <h3>Methods</h3> Patients NMDA receptor (NMDAR)-AE, leucine-rich glioma-inactivated-1 (LGI1)- AE, contactin-associated protein-like-2 (CASPR2)-AE, or glutamic acid decarboxylase 65 (GAD65) disease from GErman Network for Research on AuToimmune Encephalitis who had received at least 1 dose a control cohort non–rituximab-treated patients...
Abstract SARS-CoV-2 RT-PCR is a critical and, at times, limited resource. Frequent Retesting of patients may strain testing infrastructure unduly. Recommendations that include cycle threshold (Ct) cutoffs incentivize early retesting when the Ct value reported. We aimed to investigate patterns in association with initial Ct-values. performed retrospective analysis results (including Ct-values) for from whom ≥ 2 samples were collected within 14 days, first which had be positive. calculated...
Heterologous vaccinations against SARS-CoV-2 with ChAdOx1 nCoV-19 and a second dose of an mRNA-based vaccine have been shown to be more immunogenic than homologous nCoV-19. In the current study, we examined kinetics antibody response three different vaccination regimens (homologous vs. + BNT162b2 or mRNA-1273) in longitudinal manner; whether there are differences latency amplitude early which markers most suitable detect these responses.We performed assays for anti-S1 IgG IgA, anti-NCP...
Summary Coronavirus disease 2019 (COVID-19) displays high clinical variability but the parameters that determine severity are still unclear. Pre-existing T cell memory has been hypothesized as a protective mechanism conclusive evidence is lacking. Here we demonstrate all unexposed individuals harbor SARS-CoV-2-specific cells with marginal cross-reactivity to common cold corona and other unrelated viruses. They display low functional avidity broad protein target specificities their...
Abstract Differential diagnosis between Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA) using cerebrospinal fluid (CSF) biomarkers is challenging. A recent study suggested that the addition of Aβ38 Aβ43 to a standard AD biomarker panel (Aβ40, Aβ42, t‐tau, p‐tau) improve differential diagnosis. We tested this hypothesis in an independent German cohort CAA patients controls same analytical techniques. found excellent discrimination controls, but not CAA. Adding did
Abstract Laboratory testing for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) consists of two pillars: detection viral RNA via rt-PCR as diagnostic gold standard in cases, and antibodies against SARS-CoV-2. However, concerning latter, questions remain about their prognostic value it is not clear whether all patients develop detectable antibodies. We examined sera from 347 Spanish COVID-19 patients, collected during peak epidemic outbreak Spain, presence IgA IgG SARS-CoV-2...
Abstract Objectives To better characterize occurrence and extent of anticoagulant-associated pseudothrombocytopenia (PTCP) in the daily routine a high-throughput clinical laboratory order to draw conclusions on more precise definition this phenomenon. Methods Concomitant platelet counts both EDTA citrate whole blood (WB) performed our over period four years 9 months, were analyzed, calculating correlation, as well absolute difference results obtained from materials, cross-referencing these...
Paired associative stimulation (PAS), a form of non-invasive cortical pairing transcranial magnetic (TMS) with peripheral sensory stimulus, has been shown to induce neuroplastic effects in the human motor, somatosensory and auditory cortex. The current study investigated acoustic PAS on late evoked potentials (LAEP) influence tone duration placebo stimulation. In two experiments, 18 participants underwent 4 kHz paired 400 ms using 200 pairs stimuli (TMS-pulse over left cortex 45 after...
Abstract The pandemic spread of the potentially life-threatening disease COVID-19 requires a thorough understanding longitudinal dynamics host responses. Temporal resolution cellular features associated with severe trajectory will be pre-requisite for finding outcome predictors. Here, we performed multi-omics study using two-centre German cohort 13 patients (from Cologne and Kiel, 1). We analysed bulk transcriptome, DNA methylome, single-cell transcriptome (>358,000 cells, including BCR...
•Antibodies against SARS-CoV-2 were associated with lower viral loads of SARS-CoV-2•Higher on admission a fatal outcome•Cycle threshold values different assays and target genes not readily comparable ObjectivesTo examine the relationship between antibody status cycle (Ct) values, prognostic value latter for COVID-19 patients, inter-assay comparability Ct values.MethodsIn 347 inpatients, (via reverse transcription-quantitative polymerase chain reaction) compared 2 correlated response (in...
Ziel/Aim Ziel dieser Arbeit ist es, den Einfluss des Folsäurespiegels im Rahmen der PSMA-PET/CT-Bildgebung bei Patienten mit Prostatakarzinomen zu untersuchen. Da die physiologische enzymatische Aktivität PSMA in vitro durch Zugabe von Folsäure gehemmt werden kann und zur Bildgebung verwendeten PSMA-Liganden ebenfalls an das aktive Zentrum dieses Enzyms binden, könnte sich infolge einer kompetitiven Hemmung eine Konsequenz für ergeben.