A5034529168- COVID-19 Clinical Research Studies
- Emergency and Acute Care Studies
- COVID-19 and healthcare impacts
- Trauma and Emergency Care Studies
- Long-Term Effects of COVID-19
- Retinal and Optic Conditions
- Respiratory Support and Mechanisms
- Cardiac Arrest and Resuscitation
- Airway Management and Intubation Techniques
- Peptidase Inhibition and Analysis
- Cerebral Venous Sinus Thrombosis
- Acute Ischemic Stroke Management
- Inflammasome and immune disorders
- Respiratory and Cough-Related Research
- Social Policies and Healthcare Reform
- Vitamin C and Antioxidants Research
- COVID-19 Digital Contact Tracing
- Neuroscience of respiration and sleep
- Ocular Diseases and Behçet’s Syndrome
- Health and Medical Studies
- Radiation Dose and Imaging
- Healthcare cost, quality, practices
- Simulation-Based Education in Healthcare
- Social and Demographic Issues in Germany
- Voice and Speech Disorders
University Hospital Schleswig-Holstein
2020-2025
University of Lübeck
2020-2025
Universitäts Hautklinik Kiel
2021-2025
German Center for Infection Research
2024
Kiel University
2021
Deutsche Interdisziplinäre Vereinigung für Intensiv- und Notfallmedizin
2020
University Hospital Regensburg
2012
Klinikum rechts der Isar
2003
Abstract The receptor-interacting serine/threonine protein kinase 1 (RIPK1) is a key mediator of regulated cell death and inflammation. Recent studies suggest that RIPK1 inhibition would fundamentally improve the therapy RIPK1-dependent organ damage in stroke, myocardial infarction, kidney failure, systemic inflammatory response syndrome. Additionally, it could ameliorate or prevent multi-organ failure induced by cytokine release context hyperinflammation, as seen COVID-19 patients....
Dipeptidylpeptidase (DPP)-4 is a key regulator of the incretin system. For several years DPP-4 inhibitors in addition to GLP-1 analogues are major importance clinical management obesity and type 2 diabetes. also known as CD26 represents membrane bound protease on surface eukaryotic cell types. Of interest, DPP-4, like ACE2, has been shown serve binding partner for corona-like viruses enter host immune cells. Since metabolic diseases risk factors present COVID-19 pandemic, we examined...
Abstract Background During the COVID-19 pandemic and associated public health social measures, decreasing patient numbers have been described in various healthcare settings Germany, including emergency care. This could be explained by changes disease burden, e.g. due to contact restrictions, but also a result of utilisation behaviour population. To better understand those dynamics, we analysed routine data from departments quantify consultation numbers, age distribution, acuity day hour...
Background: The purpose of this study is the evaluation imaging findings acute-phase cardiac CT (cCT) in stroke patients with large vessel occlusion (LVO) to identify potential cardioembolic sources (CES) without intracardiac thrombi and atrial fibrillation (AF). Material Methods: This retrospective included 315 LVO who underwent cCT acute setting. images were analysed for 15 following established minor major risk factors. final aetiology was determined using TOAST classification through...
The planned hospital and emergency care reform in Germany aims, among other things, to restructure services towards integrated centers (INZ) for children adolescents (KINZ). There is a gap current data on the reasons presentation use of departments by patients under 18 years age. This study provides multicenter analysis most common German departments. In retrospective, descriptive cross-sectional analysis, were collected from 251,570 age January 1, 2019, June 30, 2022, across 22 (including...
Zusammenfassung Einleitung In Notaufnahmen kommen bundesweit nichttraumatologische kritisch kranke Patienten zur Aufnahme. Zur Struktur, Organisation und Ausstattung des nichttraumatologischen Schockraummanagements ist bisher wenig bekannt. Mittels einer Umfrage sollte daher der Ist-Zustand analysiert werden. Methodik Durch die Arbeitsgruppe „Schockraum“ Deutschen Gesellschaft Interdisziplinäre Notfall- Akutmedizin (DGINA) wurde mittels E‑Mail den 420 ärztlichen Leiter*Innen...
Abstract Background In this retrospective routine data analysis, we investigate the number of emergency department (ED) consultations during COVID-19 pandemic 2020 in Germany compared to previous year with a special focus on numbers myocardial infarction and acute heart failure. Methods Aggregated case for two consecutive years 2019 were obtained from 24 university hospitals 9 non-university assessed by age, gender, triage scores, disposition, care level ICD-10 codes including tracer...
Objective The aim of this study was to determine the best airway device among laryngeal mask, I-gel and tube used by healthcare professional groups with different levels experience paediatric management. Method Three professionals were separately provided brief supervised training in using three devices. Afterwards participants asked place device. For every participant, positioning each recorded. success rate timing insertion measured. Furthermore, scored for ease insertion, clinical...
Purpose To describe findings on cerebral imaging in patients with COVID-19 and neurological symptoms at two German university hospitals. Materials Methods Patients (CT or MRI) were included. A chart review regarding symptoms, was conducted. Results 12 (4 females, age 68 ± years) could be Three had acute findings. Two subacute ischemia, one patient additional intracranial hemorrhages presumed central pontine myelinolysis. One COVID-19-associated pansinusitis. Conclusion Findings are uncommon...
Objectives One major goal of the emergency department (ED) is to decide, whether patients need be hospitalised or can sent home safely. We aim at providing criteria for these decisions without knowing SARS-CoV-2 test result in suspected cases. Setting Tertiary medicine. Participants All were treated ED Charité during pandemic peak and underwent testing. Patients with positive results characterised detail a 14-day-follow-up. Primary secondary outcome measures Logistic regression...
There are only few reports on ocular symptoms and manifestations in association with coronavirus disease 2019 (COVID-19).The aim of this study is to describe the anterior posterior segments eye analyze viral prevalence tears patients COVID-19.Hospitalized COVID-19 treated from 16 April 2020 7 January 2021 at hospital were screened for segments. Conjunctival swabs analyzed severe acute respiratory syndrome 2 (SARS-CoV-2) RNA.A total 37 enrolled study. In segment we found chemosis conjunctiva...
Background: The Emergency Department (ED) is directly involved in diagnosis and initial treatment of all stages COVID-19. One major goal the ED to decide, whether patients need be hospitalized or can sent home safely. These decisions must usually made without knowing SARS-CoV-2 test result.Methods: We retrieved who were treated at Charité (Berlin, Germany) during pandemic peak between March 1 April 15, 2020 underwent testing using an oro-naso-pharyngeal swab. All with positive results...
German emergency departments have experienced significant development in recent years due to changes health care policy as well continued professionalism department medical care. The Medical Association has taken this into account and included an additional post residency fellowship training program medicine their 2018 model regulation guidelines. specialized covers the initial diagnosis treatment of patients decision making coordination further specialist interdisciplinary cooperation....
Zusammenfassung Hintergrund Die aktuelle COVID-19-Pandemie stellt, trotz der Verfügbarkeit von Schnelltests und des Starts Impfkampagne, die Notaufnahme weiterhin vor große Herausforderungen. strukturierte Erfassung demographischen, klinischen sowie therapiebezogenen Daten stellt Grundlage für Erstellung evidenzbasierter Prozesse Behandlungskonzepte dar. Ziel Arbeit Darstellung systematischen klinischer Parameter bei Patienten mit COVID-19-Verdacht im Notaufnahmeregister ReCovER ( Registry...
Aims Dipeptidylpeptidase is a key regulator of the incretin system. Initially, it's soluble form (sDPP-4) was described as an adipokine mediating metabolic inflammation. This recently questioned in mechanistic rodent studies. To further clarify sDPP-4's role physiology and diseases, we examined sDPP-4 large human cohort during weight-loss interventions. Like ACE2, serves binding partner for certain corona-like viruses enabling virus entry. As diseases are major risk factors COVID-19...