A5074864491- Diet and metabolism studies
- Pharmacovigilance and Adverse Drug Reactions
- Gut microbiota and health
- Maternal and Perinatal Health Interventions
- Respiratory and Cough-Related Research
- Asthma and respiratory diseases
- Influenza Virus Research Studies
- Pharmaceutical studies and practices
- Peptidase Inhibition and Analysis
- Diabetes Treatment and Management
- Vaccine Coverage and Hesitancy
- Drug-Induced Adverse Reactions
- Neuropeptides and Animal Physiology
- SARS-CoV-2 and COVID-19 Research
- Bacterial Infections and Vaccines
- Adipokines, Inflammation, and Metabolic Diseases
- Tryptophan and brain disorders
- Maternal and fetal healthcare
- Virology and Viral Diseases
- Herpesvirus Infections and Treatments
- Epigenetics and DNA Methylation
- Nutritional Studies and Diet
- COVID-19 Clinical Research Studies
- Nutrition, Genetics, and Disease
- Liver Disease Diagnosis and Treatment
University Hospital Schleswig-Holstein
2017-2024
University of Lübeck
2017-2024
The Geneva Association
2024
University Medical Center
2022-2023
Kiel University
2017-2023
Marqués de Valdecilla University Hospital
2023
Hospital Universitario de Canarias
2023
Queen Mary University of London
2023
International Federation of Gynaecology and Obstetrics
2023
International Confederation of Midwives
2023
Recent rodent microbiome experiments suggest that besides Akkermansia, Parasutterella sp. are important in type 2 diabetes and obesity development. In the present translational human study, we aimed to characterize our European cross-sectional FoCus cohort (n = 1,544) followed by validation of major results an independent Canadian 438). addition, examined abundance response a weight loss intervention 55). was positively associated with BMI independently reduced α/β diversity low-grade...
Research suggests 1 in 3 births are experienced as psychologically traumatic and about 4% of women 1% their partners develop post-traumatic stress disorder (PTSD) a result. To provide expert consensus recommendations for practice, policy, research theory. Two consultations (n = 65 n 43) with an international group researchers clinicians from 33 countries involved COST Action CA18211; three meetings CA18211 leaders stakeholders; followed by review feedback people lived experience members...
Abstract Background The traditional binary classification of diabetes into Type 1 and 2 fails to capture the heterogeneity among patients. This study aims identify characterize subtypes within German FoCus cohort, using ANDIS cohort's framework, explore subtype-specific variations in metabolic markers, gut microbiota, lifestyle, social factors, comorbidities. Methods We utilized data from 416 participants (208 with 208 matched metabolically healthy controls) cohort. Participants were...
OBJECTIVE Gut microbiota represent a potential novel target for future prediabetes and type 2 diabetes therapies. In that respect, niacin has been shown to beneficially affect the host-microbiome interaction in rodent models. RESEARCH DESIGN AND METHODS We characterized more than 500 human subjects with different metabolic phenotypes regarding their (nicotinic acid [NA] nicotinamide [NAM]) status gut microbiome. addition, NA NAM delayed-release microcapsules were engineered examined vitro...
A woman's right to respectful and dignified care during labour childbirth is strategically accepted.1 As management committee members of the EU COST Action CA18211 network ('DEVOTION') focused on traumatic (www.ca18211.eu), we are concerned with ensuring a positive birth experience for all. We work pan-European level ensure women's rights give in clinically psychologically safe environment including current COVID-19 pandemic. every country reacted pandemic, swift initial response was based...
This analysis describes the successes, challenges and opportunities to improve global vaccine safety surveillance as observed by Vaccine Safety Working Group from its role a platform of exchange for stakeholders responsible monitoring vaccines distributed through COVAX mechanism. Three key elements considered be essential ongoing future pandemic preparedness developers in their interaction with other members ecosystem are (1) availability infrastructure capacity active low-income...
Dipeptidylpeptidase (DPP)-4 is a key regulator of the incretin system. For several years DPP-4 inhibitors in addition to GLP-1 analogues are major importance clinical management obesity and type 2 diabetes. also known as CD26 represents membrane bound protease on surface eukaryotic cell types. Of interest, DPP-4, like ACE2, has been shown serve binding partner for corona-like viruses enter host immune cells. Since metabolic diseases risk factors present COVID-19 pandemic, we examined...
The interplay between bile acids (BAs) and metabolic diseases has gained importance in recent years, with a variety of studies investigating their relationship diverging results. Therefore, the present study we performed detailed analysis BA metabolism 492 subjects different phenotypes. Besides microbiomics metabolomics this investigation included silico community to examine interchange microbes as well human host. Our findings revealed distinct changes profiles patients diabetes...
Common nutrition-associated diseases like obesity and type 2 diabetes are linked to chronic low-grade inflammation. The secreted glycopeptide wingless-type mouse mammary tumor virus integration site family member 5a (wnt5a) has been implicated in metabolic inflammation rodent models, suggesting a potential treatment target. Data on the role of wnt5a human physiology have yielded conflicting results. Serum concentrations were measured cross-sectional cohort 896 people gain deeper insights...
Abstract Context Dipeptidylpeptidase (DPP)-4 is a key regulator of the incretin system. It exists in membrane-bound form and soluble (sDPP-4). Initial human studies suggested sDPP-4 to be an adipokine involved metabolic inflammation. However, recent mechanistic data genetically modified mice has questioned these findings. Objectives We examined circulating cohort n = 451 humans with different phenotypes during 3 weight loss interventions (n 101) further clarify its role physiology diseases....
<i>Background: </i>The Swiss Drug Monitoring Center (SANZ) uses a systematic approach to the collection of spontaneously reported individual cases on suspected adverse drug reactions (ADRs). Spontaneous reporting schemes are designed detect new, rare and unexpected ADRs act as an early warning system but there is tendency overreport severe reactions. <i>Objectives:</i> The aim study was determine drug-induced episodes bronchospasm, their seriousness predisposing risk...
The present study aimed to prove the metyrapone short test in a day clinic be suitable for examining integrity of hypothalamic-pituitary-adrenal (HPA) axis patients with suspected secondary and tertiary adrenal insufficiency identify novel effector molecules acute stress response.44 were prospectively enrolled. Based on stimulated 11-deoxycortisol levels, divided into physiological (11-deoxycortisol ≥70 μg/L) pathological <70 response group. Clinical follow-up examination was performed...
From 1995 until June 1998 123 new chemical entities (NCEs) were launched in Switzerland. In this time period 250 reports of adverse reactions (ADRs) involving 56 different NCEs reported to the Swiss Drug Monitoring Center SANZ directly by physicians within voluntary spontaneous reporting scheme (SRS). No cases from observational or clinical postmarketing studies included. Of 88% suspected be drug-related and 20% them serious. 64% ADRs unlabelled not notified health professionals. Disorders...