Angel Angelov
A5034687804- Genomics and Phylogenetic Studies
- Biofuel production and bioconversion
- Bacterial Genetics and Biotechnology
- Enzyme Production and Characterization
- Microbial Metabolic Engineering and Bioproduction
- Microbial Community Ecology and Physiology
- SARS-CoV-2 and COVID-19 Research
- Bacteriophages and microbial interactions
- Microbial Metabolites in Food Biotechnology
- Enzyme Structure and Function
- Antibiotic Resistance in Bacteria
- Enzyme Catalysis and Immobilization
- COVID-19 Clinical Research Studies
- Business and Economic Development
- Microbial Natural Products and Biosynthesis
- Probiotics and Fermented Foods
- Polysaccharides and Plant Cell Walls
- Bacterial biofilms and quorum sensing
- SARS-CoV-2 detection and testing
- COVID-19 epidemiological studies
- Amino Acid Enzymes and Metabolism
- Protist diversity and phylogeny
- Animal Nutrition and Physiology
- Economic and Business Development Strategies
- Studies on Chitinases and Chitosanases
Technical University of Munich
2015-2025
King Abdullah University of Science and Technology
2022-2025
Core Laboratories (United States)
2025
Universitätsklinikum Tübingen
2019-2024
Bernstein Center for Computational Neuroscience Tübingen
2021-2024
University of Tübingen
2022-2024
Ministry of Interior
2022
Institute of Medical Microbiology and Hygiene
2021-2022
American Society of Safety Professionals
2022
Heinrich Heine University Düsseldorf
2021
Fast and reliable detection of patients with severe heterogeneous illnesses is a major goal precision medicine1,2. Patients leukaemia can be identified using machine learning on the basis their blood transcriptomes3. However, there an increasing divide between what technically possible allowed, because privacy legislation4,5. Here, to facilitate integration any medical data from owner worldwide without violating laws, we introduce Swarm Learning-a decentralized machine-learning approach that...
The euryarchaea Picrophilus torridus and oshimae are able to grow around pH 0 at up 65°C, thus they represent the most thermoacidophilic organisms known. Several features that may contribute survival strategy of P. were deduced from analysis its 1.55-megabase genome. has smallest genome among nonparasitic aerobic microorganisms growing on organic substrates simultaneously highest coding density thermoacidophiles. An exceptionally high ratio secondary over ATP-consuming primary transport...
Sourdough has played a significant role in human nutrition and culture for thousands of years is still eminent importance diet the bakery industry. Lactobacillus sanfranciscensis predominant key bacterium traditionally fermented sourdoughs.The genome L. TMW 1.1304 isolated from an industrial sourdough fermentation was sequenced with combined Sanger/454-pyrosequencing approach followed by gap closing walking on fosmids. The sequencing data revealed circular chromosomal sequence 1,298,316 bp...
ABSTRACT The increasing production of synthetic and natural poly( cis -1,4-isoprene) rubber leads to huge challenges in waste management. Only a few bacteria are known degrade rubber, little is about the mechanism microbial degradation. genome Gordonia polyisoprenivorans strain VH2, which one most effective rubber-degrading bacteria, was sequenced annotated elucidate degradation pathway other features this actinomycete. consists circular chromosome 5,669,805 bp plasmid 174,494 with average...
Functional metagenomic screening strategies, which are independent of known sequence information, can lead to the identification truly novel genes and enzymes. Since E. coli has been used exhaustively for this purpose as a host, it is important establish alternative expression hosts use them functional new In study we show that Thermus thermophilus HB27 an excellent host be provider biocatalysts. previous constructed mutant strain BL03 with multiple markerless deletions in major extra-...
Discovery of novel antibiotics is crucial for combating rapidly spreading antimicrobial resistance and new infectious diseases. Most the clinically used are natural products-secondary metabolites produced by soil microbes that can be cultured in lab. Rediscovery these secondary during discovery expeditions costs both time resources. Metagenomics approaches overcome this challenge capturing culturable unculturable hidden microbial diversity. To effective, such an approach should address...
Abstract Background Long-read whole genome sequencing (lrWGS) has the potential to address technical limitations of exome in ways not possible by short-read WGS. However, its utility autosomal recessive Mendelian diseases is largely unknown. Methods In a cohort 34 families which suspected remained undiagnosed sequencing, lrWGS was performed on Pacific Bioscience Sequel IIe platform. Results Likely causal variants were identified 13 (38%) cohort. These include (1) homozygous splicing SV TYMS...
Natural transformation has been described in bacterial species spread through nearly all major taxonomic groups. However, the current understanding of structural components and regulation competence development is derived from only a few model organisms. Although natural was discovered members Actinobacteria (high GC Gram-positive bacteria) more than four decades ago, or system have not studied any representative entire phylum. In this report we identify new role for distinct type pilus...
Agro-industrial residues are low-cost carbon sources (C-sources) for microbial growth and production of value-added bioproducts. Among the agro-industrial available, those rich in pectin generated high amounts worldwide from sugar industry or industrial processing fruits vegetables. Sugar beet pulp (SBP) hydrolysates contain predominantly neutral sugars d-glucose, l-arabinose d-galactose, acidic d-galacturonic acid. Acetic acid is also present at significant concentrations since acetylated....
Abstract Background Tracing of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission chains is still a major challenge for public health authorities, when incidental contacts are not recalled or perceived as potential risk contacts. Viral sequencing can address key questions about SARS-CoV-2 evolution and may support reconstruction viral networks by integration molecular epidemiology into classical contact tracing. Methods In collaboration with local we set up an...
ABSTRACT Actinobacteria have frequently been reported in the Andean Puna, including strains of genus Micrococcus . These demonstrate resistance to high levels UV radiation, arsenic, and multiple antibiotics, possess large linear plasmids. A comparative analysis sequences putative functions these plasmids was conducted. The presence regions with sequence identity (exceeding 30 kb total) all three studied megaplasmids indicates a clear evolutionary link among elements. Genes related essential...
<title>Abstract</title> <bold>Background</bold> In this study, xTitan, a field-deployable, automated, and versatile nucleic acid extraction system was employed to characterize microbial communities in Red Sea-derived samples, including coral colonies, mangrove sediments, seawater. The use of the xTitan field intended minimize sample transport bias, obtaining data that may be closer “ground truth” for diversity. observed from DNA extracted using were compared extractions performed laboratory...
ObjectiveThe aim of this study was to carry out whole-genome sequencing (WGS) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), using samples collected from Congolese individuals between April and July 2020.MethodsNinety-six were screened for SARS-CoV-2 RT-PCR, 19 with Ct values <30 sequenced Illumina Next-Generation Sequencing (NGS). The genomes annotated mutations the web tool 'coronapp'. Subsequently, different lineages assigned PANGOLIN Nextclade.ResultsEleven successfully...
Enzymatic degradation of plant biomass requires the coordinated action various enzymes. In this study, production reducing sugars from pectic substrates and sugar beet pulp (SBP) was investigated compared using commercial enzyme preparations, including M2, pectinase (E1), Viscozyme L (V-L) L-40. V-L, a cellulolytic mix produced by Aspergillus sp. further evaluated as most robust cocktail with strongest SBP ability in terms release monosaccharides, methanol, acetate SBP....