A5005578444- Opioid Use Disorder Treatment
- Pain Mechanisms and Treatments
- Pain Management and Opioid Use
- Musculoskeletal pain and rehabilitation
- Probiotics and Fermented Foods
- Anesthesia and Pain Management
- Diet, Metabolism, and Disease
- Microbial Metabolites in Food Biotechnology
- Pain Management and Placebo Effect
- Enzyme Production and Characterization
- Gut microbiota and health
- Peptidase Inhibition and Analysis
- Moringa oleifera research and applications
- Enzyme Catalysis and Immobilization
- Pharmaceutical and Antibiotic Environmental Impacts
- Botulinum Toxin and Related Neurological Disorders
- Ion Channels and Receptors
- Genomics and Phylogenetic Studies
- Marine and coastal plant biology
- Pharmacological Effects and Assays
- Food Quality and Safety Studies
- Blood Pressure and Hypertension Studies
- Barrier Structure and Function Studies
- Neurotransmitter Receptor Influence on Behavior
- Vibrio bacteria research studies
Collegium Pharmaceutical (United States)
2017-2023
ORCID
2023
Centrexion Therapeutics (United States)
2021
Clinical Solutions
2018
Max Rubner Institut
2015-2016
University of Arizona
2010-2016
Kiel University
2010-2011
Clinical Research Center Kiel
2010
Summary Marine macroalgae are constantly exposed to epibacterial colonizers. The epiphytic bacterial patterns and their temporal spatial variability on host algae poorly understood. To investigate the interaction between marine bacteria, this study tested if composition of communities different was specific persisted under varying biotic abiotic environmental conditions over a 2‐year observation time frame. Epibacterial co‐occurring Fucus vesiculosus, Gracilaria vermiculophylla Ulva...
Pain is aversive, and its relief elicits reward mediated by dopaminergic signaling in the nucleus accumbens (NAc), a part of mesolimbic motivation pathway. How pathway engaged pain-relieving treatments not known. Endogenous opioid anterior cingulate cortex (ACC), an area encoding pain aversiveness, contributes to modulation. We examined whether endogenous ACC neurotransmission required for subsequent downstream activation NAc dopamine signaling. Conditioned place preference (CPP) vivo...
To gain some specific insight into the roles microorganisms might play in non-alcoholic fatty liver disease (NAFLD), intestinal and lactic acid bacteria one yeast (Anaerostipes caccae, Bacteroides thetaiotaomicron, Bifidobacterium longum, Enterococcus fecalis, Escherichia coli, Lactobacillus acidophilus, fermentum, plantarum, Weissella confusa, Saccharomyces cerevisiae) were characterized by high performance liquid chromatography for production of ethanol when grown on different...
Hypoxia (Hx) is a component of many disease states including stroke. Ischemic stroke occurs when there restriction cerebral blood flow and oxygen to part the brain. During ischemic, subsequent reperfusion phase stroke, blood–brain barrier (BBB) integrity lost with tight junction (TJ) protein disruption. However, mechanisms Hx reoxygenation (HR)-induced loss BBB are not fully understood. We examined role kinase C (PKC) isozymes in modifying TJ expression rat model global Hx. The (6% O 2 )...
Many aspects of study conduct impact the observed effect size treatment. Data were utilized from a recently published meta-analysis randomized, double-blind, placebo-controlled, clinical trials performed for United States Food and Drug Administration (FDA) approval full mu-agonist opioids treatment chronic pain.The number sites in each trial standardized (SES) extracted computed. Standardized was plotted against sites, two-piece linear model fit to plot. Ten studies included.The SES...
ABSTRACT In 2011, one of the world's largest outbreaks hemolytic-uremic syndrome (HUS) occurred, caused by a rare Escherichia coli serotype, O104:H4, that shared virulence profiles Shiga toxin-producing E. (STEC)/enterohemorrhagic (EHEC) and enteroaggregative (EAEC). The persistence fitness factors highly virulent EHEC/EAEC O104:H4 strain, grown either in food or vitro , were compared with those O157 outbreak-associated strains. log reduction rates different EHEC strains during maturation...
Objective: To further characterize the human abuse potential and pharmacokinetics (PK) of Oxycodone DETERx (Xtampza® ER) after intact chewed oral administration.Design: Randomized, double-blind, triple-dummy, active- placebo-controlled, single-dose, six-period, crossover comparison study.Setting: Clinical research unit.Subjects: Adult, nondependent recreational opioid users who liked effects crushed immediate-release (IR) oxycodone in solution were able to differentiate from placebo...
The standard of care calls for the assessment patients with chronic pain prior to initiation opioids, one part this including risk misuse medications. However, traditional opioid tools focus almost entirely on individual factors and addiction opioids. Diversion medications has been found be not uncommon, but date, there have no specifically designed assess diversion. In study, we developed a measure an medication ending up in hands someone other than patient whom they were prescribed. A...
This post hoc analysis of data from a randomized, double-blind, placebo-controlled, enriched-enrollment randomized-withdrawal Phase III study evaluated the safety, tolerability, and analgesic efficacy Oxycodone DETERx extended-release (ER), abuse-deterrent capsules (Xtampza® ER) in subjects with chronic low back pain who were successfully transitioned immediate-release (IR) oxycodone.Continuous outcomes analyzed using mixed-model repeated-measures approach; binomial chi-squared;...
To obtain broad regulatory approval for a new analgesic agent in acute postoperative pain, US and European authorities require pivotal studies both hard (bony) tissue pain soft pain. Bunionectomy is by far the most common trial model, spite of fact that model has limited relevance to clinicians prescribing drugs (pain from bunionectomy not extreme or long-lasting, adequately treated existing drugs). The authors outline experimental characteristics make an appealing study researchers despite...
Background: Previous data suggest that tapentadol, an atypical opioid with a putative dual mechanism of action, has relatively low rates abuse. A better understanding the abuse among different prescription opioids may help clinicians when considering their potential risks and benefits. The results urine drug tests (UDTs) provide unique opportunity to answer this question.Method: To investigate prescription-opioid in retrospective study, we examined test from patients seeking treatment at...
In the mammalian central nervous system, opioid receptors and their endogenous ligands are involved in mediating reinforcing effects of natural rewards such as food. Endogenous system also plays an important role pain analgesia. Human neuroimaging studies have demonstrated that peptides (EOPs) released cortical subcortical regions brain during appetitive food consumption, well following acute stimulus. Dynamic monitoring EOPs laboratory animals, however, has been limited due to low...