A5015887566- Antibiotic Resistance in Bacteria
- Nosocomial Infections in ICU
- Antibiotic Use and Resistance
- Clostridium difficile and Clostridium perfringens research
- Bacterial Identification and Susceptibility Testing
- Infection Control in Healthcare
- Complementary and Alternative Medicine Studies
- Antimicrobial Resistance in Staphylococcus
- SARS-CoV-2 and COVID-19 Research
- Microscopic Colitis
- Immune responses and vaccinations
- Enterobacteriaceae and Cronobacter Research
- Surgical site infection prevention
- Urinary Tract Infections Management
- Primary Care and Health Outcomes
- Health Policy Implementation Science
- Long-Term Effects of COVID-19
- Healthcare cost, quality, practices
- SARS-CoV-2 detection and testing
- Multiple Sclerosis Research Studies
- Telemedicine and Telehealth Implementation
- Cytomegalovirus and herpesvirus research
- Amoebic Infections and Treatments
- Bacterial biofilms and quorum sensing
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
University Hospital Leipzig
2022-2025
Heinrich Heine University Düsseldorf
1998-2024
Leipzig University
2022-2024
Institut für Hygiene und Umwelt
2023-2024
Düsseldorf University Hospital
2015-2019
Klebsiella (K.) pneumoniae is a ubiquitous Gram-negative bacterium and common coloniser of animals humans. Today, K. one the most persistent nosocomial pathogens worldwide poses severe threat/burden to public health by causing urinary tract infections, pneumonia bloodstream infections. Affected infections are mainly immunocompromised individuals hospitalised patients. In recent years, new type has emerged associated with community-acquired such as pyogenic liver abscess in otherwise healthy...
Background: Healthcare-acquired infections due to multidrug-resistant organisms (MDR-HAIs) pose globally significant challenges healthcare systems, leading increased morbidity, mortality, and costs. According the World Health Organization, COVID-19 pandemic significantly impacted burden of MDR-HAIs. The aim this study was investigate dynamics epidemiology MDR-HAIs in inpatients at University Leipzig Medical Center (ULMC) before during pandemic. Methods: We compared data from with bacterial...
Abstract Background Tracing of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission chains is still a major challenge for public health authorities, when incidental contacts are not recalled or perceived as potential risk contacts. Viral sequencing can address key questions about SARS-CoV-2 evolution and may support reconstruction viral networks by integration molecular epidemiology into classical contact tracing. Methods In collaboration with local we set up an...
Implementation interventions in infection prevention and control (IPC) differ by recipients. The two target groups are healthcare workers directly involved patient care (“frontline”) IPC professionals as proxy agents, that is, implementation support practitioners. While both types of aim to promote compliance with clinical prevent healthcare-associated infections (HAI), their tailoring may be vastly different, for example, due different behavioural outcomes. Additionally, teams, recipients...
Reports of outbreaks concerning carbapenemase-producing Gram-negative bacteria in which the main source transmission is hospital environment are increasing. This study describes results environmental sampling a protracted polyspecies metallo-beta-lactamase GIM-1 outbreak driven by plasmids and bacterial clones Enterobacter cloacae Pseudomonas aeruginosa tertiary care center. Environmental targeting wet locations (especially sinks) was carried out on surgical intensive unit medical ward...
Abstract Purpose Superficial surgical site infections (SSI) are a common complication after abdominal surgery. Additionally, multidrug-resistant organisms (MDRO) have shown an increasing spread in recent years with growing importance for health care. As there is varying evidence on the of MDRO different fields and countries as causative agents SSI, we report our findings MDRO-caused SSI. Methods We assembled institutional wound register spanning 2015–2018 including all patients surgery SSI...
Introduction Infection prevention and control (IPC) teams are routinely confronted with intense emotions in their daily work, as they involved many change processes front-line medical staff, for example, when promoting compliance basic IPC measures. In addition, challenges due to role intermediaries. Based on former research, this study aims empower promote clinicians’ through interventions focusing the teams’ leadership skills. Methods analysis The IP-POWER (Infection Prevention head heart:...
Antiseptic bathing has garnered attention in an effort to reduce hospital-acquired infections. Previous studies have shown the efficacy of antiseptic high-risk environments, such as intensive care units (ICUs), using chlorhexidine. In this study we aimed evaluate effectiveness octenidine a potential alternative due its established popularity and widespread use Europe.
Enterobacter cloacae complex is a common cause of hospital outbreaks. A retrospective and prospective molecular analysis carbapenem-resistant clinical isolates in tertiary care center demonstrated an outbreak German-imipenemase-1 (GIM-1) metallo-beta-lactamase-producing hormaechei ssp. steigerwaltii affecting 23 patients between 2009 2016. Thirty-three were sequence type 89 by conventional multilocus typing (MLST) displayed maximum difference 49 out 3,643 targets the ad-hoc core-genome MLST...
Abstract Background The surveillance of hospital-acquired infections in Germany is usually conducted via manual chart review; this, however, proves resource intensive and prone to a certain degree subjectivity. Documentation based on electronic routine data may present an alternative methods. We compared the derived review that which was from data. Methods Data used for analyses obtained five University Leipzig Medical Center’s (ULMC) ICUs. Clinical collected according Protection against...
ABSTRACT Successful multidrug-resistant clones are increasing in prevalence globally, which makes the ability to identify these urgent. However, adequate, easy-to-perform, and reproducible typing methods lacking. We investigated whether DiversiLab (DL), an automated repetitive-sequence-based PCR bacterial system (bioMérieux), is suitable for comparing isolates analyzed at different geographic centers. A total of 39 Escherichia coli Klebsiella species previously typed by coordinating center...
Abstract Viral genome sequencing can address key questions about SARS-CoV-2 evolution and viral transmission. Here, we present an integrated system of genomic surveillance in the German city Düsseldorf, combining a) sequencing, b) genetically based identification infection clusters population, c) analysis hospital outbreaks, d) integration public health authority contact tracing data, e) a user-friendly dashboard application as central data platform. The generated (n = 320 genomes) showed...
Abstract The prevalence of Parkinson’s disease (PD) is rising, rendering it one the most common neurodegenerative diseases. Treatment and monitoring patients require regular specialized in- outpatient care. Patients with PD are more likely to have a complicated course if they become infected severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). Regular in-hospital appointments place these at risk exposure SARS-CoV-2 due travel contact other staff. However, guidelines for...
Hintergrund: In Deutschland besteht die gesetzliche Verpflichtung zur systematischen Erfassung und Bewertung von nosokomialen Infektionen (NI) Erregern mit besonderen Resistenzen Multiresistenzen (MRE). Diese leitet sich u.a. aus Studienergebnissen ab, zeigen, dass Infektionssurveillance in Verbindung Maßnahmen der Infektionskontrolle Raten nosokomialer senkt.
ABSTRACT Genomic surveillance enables the early detection of pathogen transmission in healthcare facilities and contributes to reduction substantial patient harm. Fast turnaround times, flexible multiplexing, low capital requirements make Nanopore sequencing well suited for genomic purposes; analysis data, however, can be challenging. We present NanoCore, a user-friendly method Nanopore-based facilities, enabling calculation visualization cgMLST-like (core-genome multilocus sequence typing)...
Nosokomiale Diarrhöen werden hauptsächlich durch Clostridium-difficile-Infektionen in Zusammenhang mit einer Antibiotikatherapie verursacht. Da Infektionen diesem Bakterium immer häufiger vorkommen und schwere Verläufe zunehmen, ist es wichtig, sinnvolle Präventionsmaßnahmen umzusetzen.
Kernaussagen CDI sind assoziiert mit einer hohen Krankheitslast und Mortalität. Die ist in Deutschland weder für den stationären noch ambulanten Sektor repräsentativ erhoben worden. Der Vergleich eigener Daten Referenzdaten des CDAD-KISS-Moduls NRZ erlaubt aufgrund der Streuung Ergebnisse nur bedingt eine Einschätzung individuellen Situation. stärkste bekannte Risikofaktor Antibiotikatherapie. Hohes Alter, Komorbiditäten Immunsuppression stellen bei Patienten neben Antibiotikatherapie nicht...
The risk of peripheral venous catheter (PVC) infections in inpatients is often underestimated, even if it lower than that for central catheters. Guidelines the prevention PVC-associated describe evidence-based management PVCs. aims this study were development standardized methods compliance assessment regarding PVC and evaluation self-reported knowledge implementations among healthcare providers care.We developed a checklist based on recommendation Commission Hospital Hygiene Infection...
Die klinikweite Erhebung von Prävalenzdaten für nosokomiale Infektionen und zum Antibiotikagebrauch ist eine logistische Herausforderung. Umso interessanter sind die Ergebnisse, einen Überblick über Gesamtsituation der Fachabteilungen auf Stationsebene gewähren. Das Protokoll europäische Punktprävalenz-Studie in nationalen Light-Version Kliniken realistisch umsetzbar.