A5032700618- Respiratory viral infections research
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 and COVID-19 Research
- Antibiotic Resistance in Bacteria
- Parvovirus B19 Infection Studies
- SARS-CoV-2 detection and testing
- Bacterial Identification and Susceptibility Testing
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Antibiotics Pharmacokinetics and Efficacy
- Clostridium difficile and Clostridium perfringens research
- Escherichia coli research studies
- COVID-19 diagnosis using AI
- Immunodeficiency and Autoimmune Disorders
- Microscopic Colitis
- Pneumonia and Respiratory Infections
- Pediatric health and respiratory diseases
- Organ Transplantation Techniques and Outcomes
- COVID-19 Clinical Research Studies
- Organ and Tissue Transplantation Research
- Viral-associated cancers and disorders
- Viral Infections and Immunology Research
- Congenital Anomalies and Fetal Surgery
- Nosocomial Infections in ICU
- Cytomegalovirus and herpesvirus research
- Infection Control in Healthcare
Witten/Herdecke University
2011-2022
Kliniken der Stadt Köln
2011-2019
Tulane University
2015
Centers for Disease Control and Prevention
2015
United States Naval Medical Research Unit SOUTH
2015
University of Cologne
2011-2015
Matrix Research (United States)
2015
Institut für Hygiene und Umwelt
2015
Universität Hamburg
2014
University Medical Center Hamburg-Eppendorf
2014
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Abstract Human bocavirus (HBoV), discovered in 2005, can cause respiratory disease or no symptoms at all. We confirmed HBoV infection an 8-month-old girl with hypoxia, distress, wheezing, cough, and fever. This case demonstrates that lower tract caused by lead to severe life-threatening disease.
Human bocavirus is the second autonomous human parvovirus with assumed pathogenic potential. Other parvoviruses are known to persist and even integrate into host genome, eventually contributing multi-step development of cancer. also persists in an unknown percentage clinically asymptomatic patients addition those primary infection. The aim present study was analyze role lung colorectal cancers. Therefore, formalin-fixed, paraffin-embedded, archived tumor samples were screened for DNA by PCR,...
Abstract Background Pseudomonas aeruginosa is a common pathogen causing hospital-acquired infections. Carbapenem resistance in P. either mediated via combination of efflux pumps, AmpC overexpression, and porin loss, or through an acquired carbapenemase. Carbapenemase-producing (CPPA) strains are known to cause outbreaks harbour reservoir mobile antibiotic genes, however, few molecular surveillance data available. The aim this study was analyse the prevalence epidemiology CPPA three German...
Cause for gastroenteritis range from viral, bacterial to parasitic pathogens. Rapid Multiplexing techniques like ProGastro_SSCS and xTAG_GPP can detect broad panels of pathogens simultaneously. We performed a field test with total number 347 stool samples adult hospitalized patients that were tested the Luminex xTAG GPP assay; 157 positively at least one pathogen by 30 was retested ProGastro SSCS assay. Assays compared standard routine diagnostics.Multiplexing significantly reduced time...
A case of severe diarrhoea associated with synergistic human bocavirus type 1 (HBoV) and herpes virus 6 (HHV6) is reported. The supports the hypotheses that HBoV infection under clinical conditions may depend on helper viruses, or replicates by a mechanism atypical for parvoviruses, can be specifically treated cidofovir.
Abstract Background A. baumannii is a common nosocomial pathogen known for its high transmission potential. A rate of carbapenem-susceptible Acinetobacter calcoaceticus-Acinetobacter (ACB)-complex in clinical specimens led to the implementation pathogen-based surveillance on 32-bed surgical intensive care unit (SICU) German tertiary centre. Methods Between April 2017 and March 2018, ACB-complex isolates with an epidemiological link SICU were further assessed. Identification species level was...
We present findings describing the epidemiology of non-severe acute respiratory syndrome human coronavirus-associated influenza-like illness from a population-based active follow-up study in four different regions Peru. In 2010, prevalence infections by coronaviruses 229E, OC43, NL63, or HKU1 was 6.4% participants with who tested negative for influenza viruses. Ten 11 coronavirus were identified fall–winter season. Human are Peru and relatively frequently associated
To describe the propensity of carbapenem-resistant Pseudomonas aeruginosa to spread within a hospital critical care setting.The study was conducted in 700-bed tertiary centre Cologne, Germany. P. resistant piperacillin, ceftazidime, cefepime, imipenem, meropenem and ciprofloxacin, isolated from clinical screening specimens four units 2015 2020 were analysed. Genotyping carried out by WGS (Illumina MinION). MLST, core genome MLST (cgMLST) resistome analysis performed merged with...
The human bocavirus was first detected in 2005 and since then has been found both respiratory secretions from patients with airway infections stool samples gastroenteritis. Meanwhile, four different genotypes have identified that most likely derive recombination events. Although the modified Koch's postulates not yet fulfilled completely, owing to lack of an animal model or a simple cell culture system, there is increasing evidence bocaviruses are serious participants infectious diseases GI...
In May 2011 an increasing number of cases with gastroenteric symptoms were reported in German hospitals. The patients showed mainly onset vomiting and bloody diarrhoea. Because high numbers these suffered from haemolytic uraemic syndrome (HUS), immediately HUS-inducing Shigatoxin-producing Escherichia coli suspected causing the outbreak. E. serotype O157:H7 is associated HUS a prevalence worldwide, but also non-O157 serotypes are known to initiate HUS. Characterization responsible...
A.baumannii (AB) colonisation and infection is frequent in burn patients multiple outbreaks especially with multidrug resistant strains are described units as well other intensive care units. The understanding of the transmission routes AB health settings eminent to control prevent transmission. Burn suspected spread high amounts pathogens.
We report about a 21-month-old boy presenting with chronic diarrhea and obstructive lung disease since infancy. His older brother, the first male child of non-consanguine Egyptean parents, had died at age 20 months suffering from BCGitis severe CMV infection, suggesting primary immundeficiency syndrome. found immunological dysregulation, endocrine dysfunction enteropathy compatible IPEX syndrome, therefore was listed for stem cell transplantation (SCT). <i>FOXP3</i> gene showed no associated...
Abstract In limelight of the ongoing pandemic SARS-CoV-2 testing is critical for diagnosis infected patients, contact-tracing and mitigating transmission. Diagnostic laboratories are expected to provide appropriate with maximum accuracy. Real-time reverse transcriptase PCR (RT-PCR) diagnostic standard yet many commercial kits have become available. However, only a handful studies reviewed their performance in clinical settings. The aim this study was compare overall analytical matrix...