A5062998583- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Atherosclerosis and Cardiovascular Diseases
- S100 Proteins and Annexins
- IL-33, ST2, and ILC Pathways
- Cell death mechanisms and regulation
- Signaling Pathways in Disease
- Endoplasmic Reticulum Stress and Disease
- Glycosylation and Glycoproteins Research
- Cellular transport and secretion
University Hospital Schleswig-Holstein
2024-2025
University of Lübeck
2024-2025
Kiel University
2021-2024
Metastasis is the major cause of death in cancer patients. Circulating tumor cells need to migrate through endothelial layer blood vessels escape hostile circulation and establish metastases at distant organ sites. Here, we identified membrane-bound metalloprotease ADAM17 on as a key driver metastasis. We show that TNFR1-dependent cell–induced cell death, extravasation, subsequent metastatic seeding dependent activity ADAM17. Moreover, reveal ADAM17-mediated TNFR1 ectodomain shedding...
Pulmonary T and B cells are important for protection of this mucosal barrier site. While viral infections lead to the development ectopic lymphoid structures highly similar those in germinal centers secondary organs, little is known about how T/B cooperation occurs unstructured, diffuse tissue infiltrates characteristic autoimmune diseases nonviral infections. Using a mouse model interstitial lung inflammation, we found that naive directly activated tissue. Despite absence any center-like...
Abstract Golgi membrane proteins such as glycosyltransferases and other glycan-modifying enzymes are key to glycosylation of lipids. Secretion soluble that released from their anchor by endoprotease activity is a wide-spread yet largely unexplored phenomenon. The intramembrane protease SPPL3 can specifically cleave select enzymes, enabling secretion concomitantly altering global cellular glycosylation, the entire range cleaved under physiological conditions remains be defined. Here, we...