A5091726091- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Surgical Simulation and Training
- Diverticular Disease and Complications
- Phagocytosis and Immune Regulation
- Esophageal Cancer Research and Treatment
- Liver physiology and pathology
- Diet and metabolism studies
- Genomics, phytochemicals, and oxidative stress
- Glioma Diagnosis and Treatment
- Tracheal and airway disorders
- Esophageal and GI Pathology
- Histone Deacetylase Inhibitors Research
- Pancreatic function and diabetes
- Signaling Pathways in Disease
- Gastric Cancer Management and Outcomes
- Protein Degradation and Inhibitors
- Autophagy in Disease and Therapy
- Lung Cancer Diagnosis and Treatment
- Anorectal Disease Treatments and Outcomes
- Macrophage Migration Inhibitory Factor
- Intestinal Malrotation and Obstruction Disorders
- Genetic factors in colorectal cancer
- S100 Proteins and Annexins
- Colorectal Cancer Surgical Treatments
Kiel University
2015-2025
Israelitisches Krankenhaus
2025
University Hospital Schleswig-Holstein
2013-2021
University of Lübeck
2013-2021
Clinical Research Center Kiel
2011
Metastasis is the major cause of death in cancer patients. Circulating tumor cells need to migrate through endothelial layer blood vessels escape hostile circulation and establish metastases at distant organ sites. Here, we identified membrane-bound metalloprotease ADAM17 on as a key driver metastasis. We show that TNFR1-dependent cell–induced cell death, extravasation, subsequent metastatic seeding dependent activity ADAM17. Moreover, reveal ADAM17-mediated TNFR1 ectodomain shedding...
Pancreatic ductal adenocarcinoma (PDAC) is often diagnosed when liver metastases already emerged. This study elucidated the impact of hepatic stromal cells on growth behavior premalignant and malignant pancreatic epithelial (PDECs). Liver sections tumor-bearing KPC mice comprised micrometastases displaying low proliferation located in an unobtrusive microenvironment whereas macrometastases containing more proliferating were surrounded by myofibroblasts (HMFs). In age-related syngeneic PDAC...
The antioxidant transcription factor Nrf2 confers broad cytoprotection and has a dual role in tumorigenesis. Enhancing proteasome activity is one mechanism by which can promote cancer development, e.g., colorectal cancer. This study investigated whether this potential oncogenic effect of emerges already from the epithelial adaptation to persistent oxidative stress during inflammatory bowel disease (IBD).Reactive oxygen species (ROS)-producing myeloid cells (IMCs) colon tissue patients with...
// Hendrike Knaack 1 , Lennart Lenk 2 Lisa-Marie Philipp Lauritz Miarka Sascha Rahn Fabrice Viol 3 Charlotte Hauser 4 Jan-Hendrik Egberts Jan-Paul Gundlach Olga Will 5 Sanjay Tiwari Wolfgang Mikulits 6 Udo Schumacher 7 Jan G. Hengstler 8 and Susanne Sebens Institute for Experimental Cancer Research, Christian-Albrechts-University Kiel (CAU) University Medical Center Schleswig-Holstein (UKSH) Campus Kiel, Germany Department of Pediatrics, UKSH Medicine I, Hamburg-Eppendorf, Hamburg, General,...
Appendicitis represents a common and severe gastrointestinal illness in younger individuals worldwide. The disease is characterized by an excessive inflammatory response it believed that bacterial overgrowth due to blockage of the appendix lumen might be involved. Despite high incidence, only limited data on pathophysiological changes exist; particular, innate immune responses involved are largely unknown. Real-time PCR analysis tissue samples from inflamed normal appendices demonstrated...
Metastasis management remains a long-standing challenge.High abundance of E2F1 triggers tumor progression by developing protein-protein interactions (PPI) with coregulators that enhance its potential to activate network prometastatic transcriptional targets.Methods: To identify E2F1-coregulators, we integrated high-throughput Co-immunoprecipitation (IP)/mass spectometry, GST-pull-down assays, and structure modeling.Potential inhibitors PPI discovered were found bioinformatics-based...
Pancreatic ductal adenocarcinoma (PDAC) and chronic pancreatitis, representing one risk factor for PDAC, are characterized by a marked desmoplasia enriched of pancreatic myofibroblasts (PMFs). Thus, PMFs thought to essentially promote tumorigenesis. We recently demonstrated that the adhesion molecule L1CAM is involved in epithelial–mesenchymal transition PMF-cocultured H6c7 human epithelial cells expressed already structures pancreatitis with even higher elevation primary tumors metastases...
Most patients with pancreatic ductal adenocarcinoma (PDAC) undergoing curative resection relapse within months, often liver metastases. The hepatic microenvironment determines induction and reversal of dormancy during metastasis. Both tumor growth metastasis depend on the Tumor necrosis factor (TNF)-related apoptosis-inducing ligand-receptor 2 (TRAIL-R2). This study investigated interplay TRAIL-R2 in metastases formation impact surgical resection. Although TRAIL-R2-knockdown (PancTu-I shTR2)...
No data exist concerning the appication of a new robotic system with 3 mm instruments (Senhance®, Transenterix) in infants and small children. Therefore, aim this study was to test for its feasibility, performance safety pediatric abdominal thoracic surgery piglets simulating body weight lower than 10 kg. 34 procedures (from explorative laparoscopy thoracoscopic esophageal repair) were performed 12 median age 23 (interquartile range: 12-28) days 6.9 (6.1-7.3) The Senhance® used instruments,...
Summary During the preclinical period of medical school, clinical relevance theoretical knowledge is given little attention. Medical students second year were invited to participate in an interdisciplinary congress for robot-assisted and digital surgery. The had evaluate impact on their learning motivation, decision-making a career surgery, educational curriculum. Participation increased motivation subjects, significantly interest surgical career. Most considered active involvement...
Preneoplasic and neoplastic changes of the gallbladder patients with a familial adenomatous polyposis (FAP) are rare, very little is known about their incidence in an attenuated FAP. We herein report on unique case woman FAP who shows eight distinct, partially preneoplastic differentiation patterns within mucosa, which are: (1) regular epithelium, (2) low grade biliary intraepithelial neoplasia, (3) papillary adenoma, (4) Paneth cell metaplasia, (5) goblet (6) pancreatic (7) pseudopyloric...
Robot-assisted cervical esophagectomy (RACE) enables radical surgery for tumors of the middle and upper esophagus, avoiding a transthoracic approach. However, access, narrow working space, complex topographic anatomy make this procedure particularly demanding. Our study offers stepwise description appropriate dissection planes anatomical landmarks to facilitate RACE. Macroscopic dissections were performed on formaldehyde-fixed body donors (three females, three males), according surgical...
Anastomosis in bronchoplasty using continuous suturing has become widely accepted. However, especially VATS and robotic assisted thoracic surgery (RATS) it is difficult to maintain a traction of suture over the circumference. In addition, lack haptic feedback on current systems might even further complicate precise constant maintenance traction. Recent reports absorbable barbed materials open were published with promising results. We adopted standardized application sutures (Stratafix,...
Background and Aims High frequency electrosurgery has a key role in the broadening application of liver surgery. Its molecular signature, i.e. metabolites evolving from electrocauterization which may inhibit hepatic wound healing, have not been systematically studied. Methods Human samples were thus obtained during surgery before after electrosurgical dissection subjected to two-stage metabolomic screening experiment (discovery sample: N = 18, replication 20) using gas chromatography/mass...
Summary Background In the surgical treatment of esophageal cancer, complete tumor resection is most important factor and determines long-term survival. With an increase in robotic expertise other fields surgery, robotic-assisted minimally invasive esophagectomy (RAMIE) was born. Currently, there a lack convincing data on extent expected benefits (perioperative oncologic outcomes and/or quality life). Some evidence exists that patients’ overall life physical function improves, with less...
Background: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic disorder in industrialized countries. Epigenetic regulation a key element determination of cellular faith and function plays an important role pathogenesis both malignant benign disorders.
Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic disorder in developed countries context of global obesity epidemic. A two-stage metabolic screening human biopsies (discovery set: N=33; replication N=66) including range from normal histology to severe non-alcoholic steatohepatitis (NASH) analysed correlation 252 metabolites histological NASH activity score. Six passed correction for multiple testing discovery set and two those, namely hydroquinone (HQ,...