A5076154226- Congenital gastrointestinal and neural anomalies
- Gastrointestinal motility and disorders
- Intestinal Malrotation and Obstruction Disorders
- Gut microbiota and health
- Infant Nutrition and Health
- Diet and metabolism studies
- Parkinson's Disease Mechanisms and Treatments
- Child Nutrition and Feeding Issues
- Alzheimer's disease research and treatments
- Neuroscience and Neural Engineering
- 3D Printing in Biomedical Research
- Dysphagia Assessment and Management
- Clinical Nutrition and Gastroenterology
- Advanced Sensor and Energy Harvesting Materials
- Congenital Anomalies and Fetal Surgery
- Congenital heart defects research
- Biochemical Analysis and Sensing Techniques
- Nuclear Receptors and Signaling
- Autoimmune Neurological Disorders and Treatments
- Gastrointestinal disorders and treatments
- Infant Health and Development
- Pediatric Pain Management Techniques
- Helicobacter pylori-related gastroenterology studies
- Tissue Engineering and Regenerative Medicine
- Anesthesia and Neurotoxicity Research
University of Applied Sciences Kaiserslautern
2016-2025
University Hospital Heidelberg
2007-2022
University Medical Centre Mannheim
2003-2022
Heidelberg University
2012-2022
University of Central Florida
2019
Mannheim University of Applied Sciences
2012-2013
University of Mannheim
2012-2013
Freie Universität Berlin
2002
Saarland University
1997-1999
Sysmex (Japan)
1998
The regulation of physiological gut functions such as peristalsis or secretion digestive enzymes by the central nervous system via Nervus vagus is well known. Recent investigations highlight that pathological conditions neurological psychiatric disorders might directly interfere with autonomous neuronal network – enteric system, even derive from there. By using a murine Alzheimer’s disease model, we investigated potential influence disease-associated changes on gastrointestinal properties....
Chronic pancreatitis (CP) and pancreatic cancer (PCa) are characterized by intrapancreatic neuropathic alterations, including increased neural density hypertrophy, neuritis invasion (NI) cells in PCa. The aim of this study was to identify the influence these changes on quality innervation, glia, visceral pain.Pancreatic nerve fiber qualities were immunohistochemical visualization various markers, those for sympathetic (tyrosine hydroxylase, TH) cholinergic innervation (choline...
Parkinson's disease (PD) is one of the most common neurodegenerative disorders. PD patients suffer from gastrointestinal dysfunctions and alterations autonomous nervous system, especially its part in gut wall, i.e., enteric system (ENS). Such functional deficits often occur years before classical clinical symptoms appear. Until now, only little known about PD-associated changes microbiota composition their potential implication development. In order to increase knowledge this field, fecal...
Hirschsprung's disease (HSCR) is characterized by congenital absence of ganglion cells in the gastrointestinal tract, which leads to impaired defecation, constipation and intestinal obstruction. The current diagnosis HSCR based on Rectal Suction Biopsies (RSBs), could be complex newborns. Occasionally, there a delay that can increase risk clinical complications. Consequently, room for new non-invasive diagnostic methods are objective, more logistically feasible also deliver far earlier base...
To further characterize the neurotrophic attributes of pancreatic cancer (PCa).PCa is characterized by neuropathic alterations which are resulting in pain. neuropathy, we aimed: to analyze whether PCa only limited tumor-core or they similarly encountered neural structures noncancerous pancreas, demonstrate features and finally identify responsible molecules.Nerve density area were quantified normal pancreas (NP, n=45), histologically "normal" next (NNPCa, n=61) (n=97). Growth-associated...
Complex regional pain syndrome, which is characterised by and trophic disturbances, develops frequently after peripheral limb trauma. There an increasing evidence of involvement the immune system in CRPS, recently we showed that CRPS patients have autoantibodies against nervous structures. Therefore tested sera patients, neuropathy healthy volunteers for surface-binding to primary cultures autonomic neurons differentiated neuroblastoma cell lines using flow cytometry. Thirteen 30 but none...
In Alzheimer's disease (AD), fatal neuronal cell loss occurs long before relevant evidence can lead to a reliable diagnosis. If characteristic pathological alterations take place in the enteric nervous system (ENS), it could be one of most promis
Abstract Background Braak’s hypothesis states that sporadic Parkinson’s disease (PD) follows a specific progression of pathology from the peripheral to central nervous system, and this can be monitored by detecting accumulation alpha-Synuclein (α-Syn) protein. Consequently, there is growing interest in understanding how gut (commensal) microbiome regulate α-Syn accumulation, as could potentially lead PD. Methods We used 16S rRNA shotgun sequencing characterise microbial diversity. 1 H-NMR...
Epidemiologic associations and preclinical studies suggest that amyloid pathology observed in the brain may be preceded by gastrointestinal amyloidosis.We identify a pathogenic program becomes activated enteric nervous system after exposure to bacterial amyloids, show serum A3 is an important self-amplifying mediator of this proinflammatory response.responsible for SAA3 production, attenuated curli-and recombinant SAA3-induced Saa3 up-regulation, DNA damage, replication glia.CONCLUSIONS: Our...
ABSTRACT Recently, p24A and p23 (also termed Tmp21), two members of the p24 protein family, have been proposed to function as integral receptors for COPI-vesicle coat. This study describes intracellular localization trafficking in comparison p23. For immunolocalization p23, strong reduction denaturation conditions were necessary allow antibody interaction. Both cycle continuously between intermediate compartment (IC) elements cis-Golgi network. In vivo tagged green fluorescent (GFP) revealed...
Pancreatic neuropathy in chronic pancreatitis (CP) and pancreatic cancer (PCa) is characterized by neuropathy, i.e. increased neural density hypertrophy, which are associated with neuropathic pain. To better understand the mechanism of these alterations, we aimed at achieving an in-vitro simulation intrapancreatic neuroplasticity.Dissociated myenteric plexus (MP) dorsal root ganglia (DRG) neurons newborn rats were treated normal human pancreas (NP), CP or PCa tissue extracts. Furthermore, MP...
Novel organoplatinum(II) complexes with 2-acetylthiophene thiosemicarbazone (ATTSC) were synthesized. The reaction of K2PtCl4 ATTSC in 1:1 and 1:2 metal to ligand ratios yielded 1 [Pt4(ATTSC-2H)4·4DMF] 2 [Pt(ATTSC-H)(ATTSC)Cl·3CH3OH)]. crystal structures these platinum chelates have been solved by single-crystal X-ray diffraction structure determinations revealed metalation the thiophene ring at C2 through atoms. Further characterization was performed using electronic, IR, UV/vis, NMR...