A5030492647- Pancreatic and Hepatic Oncology Research
- Galectins and Cancer Biology
- Cancer Mechanisms and Therapy
- Pancreatitis Pathology and Treatment
- Pancreatic function and diabetes
- Protein Tyrosine Phosphatases
- Adipose Tissue and Metabolism
- Cancer Cells and Metastasis
- PI3K/AKT/mTOR signaling in cancer
- Cancer Genomics and Diagnostics
- Protein Kinase Regulation and GTPase Signaling
- Melanoma and MAPK Pathways
- Lung Cancer Treatments and Mutations
- Ubiquitin and proteasome pathways
- Cytokine Signaling Pathways and Interactions
- Cancer-related Molecular Pathways
- Fatty Acid Research and Health
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Phagocytosis and Immune Regulation
- Intensive Care Unit Cognitive Disorders
- Frailty in Older Adults
- Diet and metabolism studies
- Genetic and Kidney Cyst Diseases
- Cell death mechanisms and regulation
Spanish National Cancer Research Centre
2016-2025
Centro de Investigación Biomédica en Red de Cáncer
2022-2025
Instituto de Salud Carlos III
2009-2025
Centro de Investigación del Cáncer
2017-2024
Medical Research Network
2023
Molecular Oncology (United States)
2006-2023
Hospital Dr. Nélio Mendonça
2023
Cancer Research Center
2019
Instituto Ramón y Cajal de Investigación Sanitaria
2019
Hôpital Civil de Charleroi
2018
The mRNA levels for the mitochondrial uncoupling protein (UCP1) in fat tissues of A/J and C57BL/6J inbred strains mice varied a regional-specific manner after stimulation adrenergic signaling by cold exposure or treatment with beta3-adrenergic agonist. While differences between were minimal interscapular brown fat, large occurred white tissues, particularly retroperitoneal fat. Among AXB recombinant strains, Ucp1 up to 130-fold. This induction at level was accompanied corresponding increase...
Nab-paclitaxel and gemcitabine have demonstrated a survival benefit over alone in advanced pancreatic cancer (PDA). This study aimed to investigate the clinical, biological, imaging effects of regimen patients with operable PDA. Patients PDA received two cycles nab-paclitaxel before surgical resection. FDG-PET CA19.9 tumour marker levels were used measure clinical activity. Effects on stroma determined by endoscopic ultrasound (EUS) elastography. The collagen content architecture as well...
Objectives: To evaluate the association between length of ICU stay and 1-year mortality for elderly patients who survived to hospital discharge in United States. Design: Retrospective cohort study a random sample Medicare beneficiaries discharge, with 1- 3-year follow-up, stratified by number days intensive care additional stratification based on receipt mechanical ventilation. Interventions: None. Patients: The included 34,696 older than 65 years received 2005. Measurements Main Results:...
Although insulin regulates metabolism in both brown and white adipocytes, the role of these tissues energy storage utilization is quite different. Recombination technology using Cre-loxP approach allows inactivation receptor a tissue-specific manner. Mice lacking receptors adipocytes show an age-dependent loss interscapular fat but increased expression uncoupling protein-1 -2. In parallel, mice develop insulin-secretion defect resulting progressive glucose intolerance, without resistance....
Oncogenic mutations in the K-ras gene occur approximately 50% of human colorectal cancers. However, precise role that oncogenes play tumor formation is still unclear. To address this issue, we have conditionally expressed an oncogenic K-ras(V12) allele small intestine adult mice either alone or context Apc deficiency. We found expression does not affect normal intestinal homeostasis immediate phenotypes associated with Mechanistically failed to find activation Raf/MEK/ERK pathway, which may...
Significance Pancreatic ductal adenocarcinoma is one of the most malignant human tumors for which there are no efficacious therapeutic strategies. This tumor type characterized by an abundant desmoplastic stroma that promotes progression. Yet recent studies have shown physical or genetic elimination leads to more aggressive development. Here, we decided reprogram stromal tissue identifying and subsequently targeting genes responsible their protumorigenic properties. Comparative transcriptome...
Pancreatic ductal adenocarcinoma (PDA) remains one of the most lethal tumor types, with extremely low survival rates due to late diagnosis and resistance standard therapies. A more comprehensive understanding complexity PDA pathobiology, especially role microenvironment in disease progression, should pave way for therapies improve patient response rates. In this study, we identify galectin-1 (Gal1), a glycan-binding protein that is highly overexpressed stroma, as major driver pancreatic...
Despite some advances, pancreatic ductal adenocarcinoma (PDAC) remains generally refractory to current treatments. Desmoplastic stroma, a consistent hallmark of PDAC, has emerged as major source therapeutic resistance and thus potentially promising targets for improved treatment. The glycan-binding protein galectin-1 (Gal1) is highly expressed in PDAC but its roles there have not been studied. Here we report functions molecular pathways Gal1 that mediate oncogenic properties this setting....