A5000931021- Diet, Metabolism, and Disease
- Infectious Diseases and Tuberculosis
- Tuberculosis Research and Epidemiology
- Liver Disease Diagnosis and Treatment
- Biochemical Acid Research Studies
- Hematological disorders and diagnostics
- Pneumocystis jirovecii pneumonia detection and treatment
- Diverse Scientific Research Studies
- Malaria Research and Control
- Tryptophan and brain disorders
- Fatty Acid Research and Health
- Neuroinflammation and Neurodegeneration Mechanisms
- Alcohol Consumption and Health Effects
- Orthopedic Infections and Treatments
- Child Nutrition and Water Access
- Gut microbiota and health
North-West University
2019-2024
Federal University of Technology Owerri
2021
Abstract Background The pathogenesis of tuberculous meningitis (TBM) involves infection by Mycobacterium tuberculosis in the meninges and brain. However, recent studies have shown that immune response inflammatory processes triggered TBM can significant effects on gut microbiota. Disruptions microbiome been linked to various systemic consequences, including altered immunity metabolic dysregulation. Inflammation caused TBM, antibiotic treatment, changes host all influence composition...
Tuberculous meningitis (TBM) is a severe form of tuberculosis with high neuro-morbidity and mortality, especially among the paediatric population (aged ≤12 years). Little known associated metabolic changes. This study aimed to identify characteristic markers that differentiate cases TBM from controls, through non-invasive urine collection. Urine samples selected for this were two groups. Group 1: controls (n = 44): children without meningitis, no neurological symptoms same geographical...
Nutritional manipulations in the neonatal period are associated with development of negative or positive health outcomes later life. Excessive fructose consumption has been attributed to increase global prevalence metabolic syndrome (MetS) and oxidative stress. Oleanolic acid (OA) anti-diabetic anti-obesity effects. We investigated protective potential orally administering OA period, prevent fructose-induced stress, adverse maturation gastrointestinal tract (GIT) suckling rats. Seven-day old...
Abstract Tuberculous meningitis (TBM)—the extrapulmonary form of tuberculosis, is the most severe complication associated with particularly in infants and children. The gold standard for diagnosis TBM requires cerebrospinal fluid (CSF) through lumbar puncture—an invasive sample collection method, currently available CSF assays are often not sufficient a definitive diagnosis. Urine metabolite-rich relatively unexplored terms its potential to diagnose neuroinfectious diseases. We used an...
An imbalance in any metabolic system can be traced to its homeostasis. When homeostatic environment is not attainable then there will a response from the body. A new shift has emerged, “the negative feedback effect of high fructose consumption;” more pain than gain. The human daily combat sugar metabolism which emanates consumption. This inadvently lead chronological series complications arising feedback. These feedbacks play pivotal roles skeletal muscle damage and other...
Malaria is a major public health problem and cause of suffering premature death in tropical subtropical countries. The population groups considered to be at higher rate contracting malaria developing severe include infants, children under 5 years age, pregnant women patients with HIV/ AIDS, non-immune migrants, mobile populations travelers. There need for constant research carried out evaluate the prevalence. This study determined infection among under-fives mothers aged 8- 40 that attended...