A5073696830- Infectious Diseases and Tuberculosis
- Tuberculosis Research and Epidemiology
- Clinical Nutrition and Gastroenterology
- Mycobacterium research and diagnosis
- Bacterial Infections and Vaccines
- Pneumonia and Respiratory Infections
- Hematological disorders and diagnostics
- Respiratory viral infections research
- Neonatal Respiratory Health Research
- Emergency and Acute Care Studies
- Nutrition and Health in Aging
- Appendicitis Diagnosis and Management
- Kawasaki Disease and Coronary Complications
- COVID-19 epidemiological studies
- Gut microbiota and health
- Mechanical Circulatory Support Devices
- Infant Development and Preterm Care
- Intestinal Malrotation and Obstruction Disorders
- Viral Infections and Outbreaks Research
- Congenital Heart Disease Studies
- Bacterial Identification and Susceptibility Testing
- Healthcare Operations and Scheduling Optimization
- Neurosurgical Procedures and Complications
- Neonatal and Maternal Infections
- Coronary Artery Anomalies
Amsterdam University Medical Centers
2019-2025
Emma Kinderziekenhuis
2016-2025
University of Amsterdam
2021-2025
University Medical Center
2004-2024
Vrije Universiteit Amsterdam
1997-2024
Great Ormond Street Hospital
2024
NIHR Great Ormond Street Hospital Biomedical Research Centre
2024
University College London
2024
National and Kapodistrian University of Athens
2024
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2023
Since May 2022, an international monkeypox (MPX) outbreak has been ongoing in more than 50 countries. While most cases are men who have sex with men, transmission is not restricted to this population. In report, we describe the case of a male child younger 10 years MPX Netherlands. Despite thorough source tracing, likely infection identified. No secondary were identified close contacts.
<h3>Importance</h3> Inappropriate antimicrobial prescribing leads to resistance and suboptimal clinical outcomes. Changing is a complex behavioral process that not often taken into account in stewardship programs. <h3>Objective</h3> To examine whether an approach grounded theory focusing on preserving prescriber autonomy participation effective improving appropriateness of hospitals. <h3>Design, Setting, Participants</h3> The Dutch Unique Method for Antimicrobial Stewardship (DUMAS) study...
Abstract We initiated a nationwide prospective study to monitor respiratory syncytial virus (RSV)–related pediatric hospitalizations in 46 hospitals throughout the Netherlands between May 2021 and August 2022. showed year-round RSV transmission after an initial summer outbreak. The pattern was unprecedented distinct from neighboring countries. extended dynamic simulation model evaluate impact of waning immunity on using 4 different scenarios. Our results suggest that observed continuous...
Central nervous system (CNS) infection by Mycobacterium tuberculosis is one of the most devastating complications tuberculosis, in particular early childhood. In order to induce CNS infection, M. needs cross specialised barriers protecting brain. How crosses blood–brain barrier (BBB) and enters not well understood. Here, we use transparent zebrafish larvae closely related pathogen marinum answer this question. We show that stages development, mycobacteria rapidly infect brain tissue, either...
Objective: Longitudinal comparison of prescribed energy, actually administered and energy expenditure (EE) predicted by Schofield's equations to actual EE, as determined daily indirect calorimetry measurements in critically ill children during the first 7 days following admission. Design: Observational study. Setting: Pediatric intensive care unit, high medium wards, a university hospital. Patients: Forty-six mechanically ventilated spontaneously breathing infants (0–18 yrs) who were...
Abstract Tuberculous meningitis (TBM) is one of the most severe extra-pulmonary manifestations tuberculosis with a high morbidity and mortality. Characteristic pathological features TBM are Rich foci, i.e. brain spinal cord-specific granulomas formed after haematogenous spread pulmonary tuberculosis. Little known about early pathogenesis role foci. We have adapted zebrafish - Mycobacterium marinum model to study TBM. First, we analyzed whether occurs in adult showed that intraperitoneal...
Children with SARS-CoV-2 related Multisystem Inflammatory Syndrome in (MIS-C) often present clinical features that resemble Kawasaki disease (KD). Disease severity adult COVID-19 is associated to the presence of anti-cytokine autoantibodies (ACAAs) against type I interferons. Similarly, ACAAs may be implicated KD and MIS-C. Therefore, we explored immunological response, correlates both disorders.Eighteen inflammatory plasma protein levels seven were measured (n = 216) MIS-C 56)...
In about 1% of tuberculosis (TB) patients, Mycobacterium (M. tuberculosis) can disseminate to the meninges, causing tuberculous meningitis (TBM) with mortality rate up 60%. Chronic granulomatous inflammation (non-necrotizing and necrotizing) in brain is histological hallmark TBM. The tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase 1 (IDO1) generated kynurenine metabolites exert major effector functions relevant TB granuloma functioning. Here we have assessed immunohistochemically...
ABSTRACT Objective We investigated the presence of mycobacteria in oral cavity and oropharynx children with nontuberculous mycobacterial (NTM) cervicofacial lymphadenitis compared to negative controls. Our aim was evaluate whether oropharyngeal swab sampling could serve as a minimally invasive alternative diagnostic excised lymph node tissue or punctate. Methods Children who underwent surgery under general anesthesia due strong clinical suspicion NTM were enrolled this multicenter...
Of all tuberculosis (TB) cases, 1% affects the central nervous system (CNS), with a mortality rate of up to 60%. Our aim is fill 'key gap' in TBM research by analyzing brain specimens unique historical cohort 84 patients, focusing on granuloma formation. We describe three different types: non-necrotizing, necrotizing gummatous, and abscess type granuloma. hypothesis that these types are developmental stages same pathological process. All were present each patient mainly localized...
To assess energy requirements and body composition in preoperative children with congenital heart disease (CHD).In 11 infants CHD (2-8 mo), total daily expenditure (TDEE) water (TBW) were measured doubly labelled compared historic data from healthy controls. Within the patient group, of versus those without congestive failure was compared. Subsequently, pooled literature meta-analyses.CHD patients showed increased TBW (mean +/- SD 66 3 vs 58 5% weight, p < 0.05) (381 42 298 36 kJ kg(-1)...
In the literature it is generally assumed that venous reflux within radicular veins prevented by presence of bicuspid valves and narrowing transdural part these vessels. Recently, we performed a human cadaver study internal vertebral plexus. Surprisingly, large number perimedullary appeared to be filled with Araldite CY 221 mixture, after injection this material into system, implicating via suggesting insufficiency presumed anti-reflux mechanism. Therefore, was decided in order determine...
Hermansky-Pudlak syndrome type 2 (HPS2) is a caused by mutations in the beta-3A subunit of adaptor protein (AP)-3 complex (AP3B1 gene). We describe five unreported cases with four novel mutations, one which aberrant pre-mRNA splicing. A point mutation c.2702C>G exon 23 AP3B1 gene deletion 112 bp mRNA two siblings. This activates cryptic donor splice site that overrules wild-type this exon. Three other were identified, is, nonsense c.716G>A (p.Trp239Ter), 1-bp and 4-bp c.177delA...
Abstract Background The pathogenesis of tuberculous meningitis (TBM) involves infection by Mycobacterium tuberculosis in the meninges and brain. However, recent studies have shown that immune response inflammatory processes triggered TBM can significant effects on gut microbiota. Disruptions microbiome been linked to various systemic consequences, including altered immunity metabolic dysregulation. Inflammation caused TBM, antibiotic treatment, changes host all influence composition...
Tuberculous meningitis (TBM) is a severe form of tuberculosis with high neuro-morbidity and mortality, especially among the paediatric population (aged ≤12 years). Little known associated metabolic changes. This study aimed to identify characteristic markers that differentiate cases TBM from controls, through non-invasive urine collection. Urine samples selected for this were two groups. Group 1: controls (n = 44): children without meningitis, no neurological symptoms same geographical...