Yvette N. Löwensteyn
A5001916816- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Neonatal Respiratory Health Research
- Viral gastroenteritis research and epidemiology
- Viral Infections and Vectors
- Tracheal and airway disorders
- Influenza Virus Research Studies
- Blood Coagulation and Thrombosis Mechanisms
- Global Maternal and Child Health
- Congenital Heart Disease Studies
- Child Nutrition and Water Access
- Vaccine Coverage and Hesitancy
- Respiratory Support and Mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
- Vitamin K Research Studies
Wilhelmina Children's Hospital
2019-2024
University Medical Center Utrecht
2019-2024
Respiratory syncytial virus (RSV) is a leading cause of pediatric death, with >99% mortality occurring in low- and lower middle-income countries. At least half RSV-related deaths are estimated to occur the community, but clinical characteristics this group children remain poorly characterized.The RSV Global Online Mortality Database (RSV GOLD), global registry under-5 who have died illness, describes dying through data sharing. GOLD acts as collaborative platform for deaths, including...
Abstract We initiated a nationwide prospective study to monitor respiratory syncytial virus (RSV)–related pediatric hospitalizations in 46 hospitals throughout the Netherlands between May 2021 and August 2022. showed year-round RSV transmission after an initial summer outbreak. The pattern was unprecedented distinct from neighboring countries. extended dynamic simulation model evaluate impact of waning immunity on using 4 different scenarios. Our results suggest that observed continuous...
Patient-level data on life-threatening respiratory syncytial virus (RSV) infection in children low-income and lower-middle-income countries (LMICs) are scarce, this scarcity might limit demand for RSV interventions LMICs who rely support from Gavi, the Vaccine Alliance. We aimed to describe characteristics of RSV-positive younger than 2 years were admitted paediatric intensive care units (PICUs) with extended severe acute (eSARI) Gavi-eligible countries.
Respiratory syncytial virus (RSV) is a major cause of mortality in children younger than 5 years worldwide. Systematic reviews have shown that Down syndrome (DS) an independent risk factor for severe RSV infection. We aimed to describe demographic and clinical characteristics with DS who died
According to the World Health Organization, global burden of nosocomial infections is poorly characterized as surveillance systems are lacking. Nosocomial occur at higher rates in low- and lower-middle-income countries (LMICs) than high-income (HICs). Current RSV estimates largely based on community-acquired infection. We aimed characterize children with RSV-related mortality understand potential impact immunization strategies.RSV GOLD a registry younger 5 years who died laboratory-confirmed...
BackgroundMucosal administration of monoclonal antibodies (mAbs) against respiratory pathogens is a promising alternative for systemic because lower doses are required protection. Clinical development mucosal mAbs highly active field yet clinical proof-of-concept lacking.MethodsIn this investigator-initiated, double-blind, randomized placebo-controlled trial, we evaluated intranasal palivizumab the prevention RSV infection in preterm infants (Dutch Trial Register NTR7378 and NTR7403). We 1:1...
Vitamin K prophylaxis in infancy aims to prevent life-threatening vitamin deficiency bleeding (VKDB). The Dutch prophylactic oral daily regimen was increased sixfold from 25 150 μg because of a high failure rate. To evaluate the efficacy this new regimen, incidences intracranial VKDB under both regimens were compared using general and targeted surveillance. Late pediatric population identified by Netherlands Pediatric Surveillance Unit, between 1 October 2014 31 December 2016. Additionally,...
Abstract Background Respiratory syncytial virus (RSV) infection is an important cause of hospitalization and death in young children. The majority deaths (99%) occur low- lower-middle-income countries (LMICs). Vaccines against RSV are underway. To obtain access to interventions, LMICs depend on support from Gavi, the Vaccine Alliance. identify future vaccine target populations, information children with severe required. However, there a lack individual patient-level clinical data instances...
Influenza virus infection is an important cause of under-five mortality. Maternal vaccination protects children younger than 3 months age from influenza infection. However, it unknown to what extent paediatric influenza-related mortality may be prevented by a maternal vaccine since global age-stratified data are lacking.We invited clinicians and researchers share clinical demographic characteristics 5 years who died with laboratory-confirmed between January 1, 1995 March 31, 2020. We...
BACKGROUND Respiratory syncytial virus (RSV) infection is an important cause of hospitalization and death in young children. The majority deaths (99%) occur low- lower-middle-income countries (LMICs). Vaccines against RSV are underway. To obtain access to interventions, LMICs depend on support from Gavi, the Vaccine Alliance. identify future vaccine target populations, information children with severe required. However, there a lack individual patient-level clinical data instances...
Reducing neonatal mortality is one of the targets Sustainable Development Goal 3 on good health and well-being. The highest rates death occur in sub-Saharan Africa. Birth asphyxia major preventable causes. Early detection timely management abnormal labour progress fetal compromise are critical to reduce global burden birth asphyxia. Labour progress, maternal well-being assessed using WHO partograph intermittent heart rate monitoring. However, low-resource settings adherence guidelines...
Abstract: Background- Globally, 33 million cases of Respiratory Syncytial Virus (RSV) infections occur annually among under-fives. Ninety-nine percent deaths from RSV in low- and middle-income countries. Under-five pneumonia mortality Nigeria was estimated at 140,520 2017, but epidemiological data is scant due to poor awareness limited testing. Vaccines for are currently under development this high-mortality low resource setting essential maximizing the potential benefit vaccination as well...
ABSTRACT Background According to the World Health Organization global burden of nosocomial infections is poorly characterized as surveillance systems for infection are lacking. Nosocomial occur at higher rates in low- and lower-middle-income countries (LMICs) than high-income (HICs). Current RSV estimates largely based on community-acquired disease. We aimed characterize children with RSV-related mortality understand potential impact immunization strategies. Methods GOLD a registry younger 5...
Abstract Objective Globally, 33 million cases of respiratory syncytial virus (RSV) infections occur annually among under-fives (5s). Ninety-nine percent deaths from RSV in low- and middle-income countries. Under-five pneumonia mortality Nigeria was estimated at 140,520 2017, but epidemiological data are scant due to poor awareness limited testing. Vaccines for currently under development this high mortality, low resource setting essential maximizing the potential benefit vaccination as well...
ABSTRACT A nationwide prospective study showed year-round RSV transmission in the Netherlands after an initial 2021 summer outbreak. The pattern was unprecedented and distinct from neighboring countries. Our dynamic simulation model suggests that this could be associated with waning immunity because of low circulation during COVID-19 pandemic.