A5013567602- Advanced Glycation End Products research
- COVID-19 Clinical Research Studies
- Polymer Nanocomposite Synthesis and Irradiation
- Cancer-related molecular mechanisms research
- Conducting polymers and applications
- Mitochondrial Function and Pathology
- Computational Drug Discovery Methods
- Long-Term Effects of COVID-19
- Nanoparticles: synthesis and applications
- SARS-CoV-2 and COVID-19 Research
- Dielectric materials and actuators
- Phytochemicals and Antioxidant Activities
- Heavy Metal Exposure and Toxicity
- Neurological Disease Mechanisms and Treatments
- Medicinal Plants and Neuroprotection
- MicroRNA in disease regulation
- Biochemical effects in animals
- Alcohol Consumption and Health Effects
- Synthesis and biological activity
- Pigment Synthesis and Properties
- Circular RNAs in diseases
- Glutathione Transferases and Polymorphisms
- Healthcare and Environmental Waste Management
- CAR-T cell therapy research
- Metal-Organic Frameworks: Synthesis and Applications
University of Ha'il
2020-2024
Umm al-Qura University
2021
Oxidative stress and antioxidants play an important role in obesity etiopathology. Genetic variants, including single nucleotide polymorphisms (SNPs) of the antioxidant-related genes, may impact disease risk several populations. This preliminary study aimed to explore association 12 SNPs related superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione-S-transferase (GST), nitric oxide synthase (NOS) genes with susceptibility a Saudi population. A total 384...
Among the plethora of debilitating neurological disorders COVID-19 syndrome in survivors, scope SARS-CoV-2-induced dysautonomia (DNS) is yet to be understood, though implications are enormous. Herein, we present an inclusive mini-review DNS and its associated complications. Although, direct link between Covid-19 DSN still speculative, hypothetical links thought either a neuronal injury autonomic pathway or para/post-infectious immune-induced mechanism. SARS-CoV-2 infection-induced stress may...
The purpose of the current investigation was to produce cinammaldehyde-based chalcone derivatives (3a–k) evaluate their potential effectiveness as antioxidant and inhibitory agents versus human Caco-2 cancer cells. findings obtained using DPPH assay showed that compound 3e had highest effective activity with best IC50 value compared other compounds. Moreover, cytotoxic revealed for inhibiting development in contrast all produced derivatives, lowest concentration (32.19 ± 3.92 µM), it also no...
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H. pylori (Helicobacter pylori) causes a common chronic infectious disease and infects around 4.4 billion people worldwide. was classified as member of the primary class stomach cancer (stomach adenocarcinoma). Hence, this study conducted to design novel lactobionic acid (LBA)-coated Zn-MOFs enhance bactericidal activity Amoxicillin (AMX) against pylori. The synthesized were characterized by various techniques which included Dynamic Light Scattering (DLS), Fourier Transform Infrared (FT-IR)...
Aging causes gradual changes in free radicals, antioxidants, and immune-imbalance the elderly. This study aims to understand links among aging, gluco-oxidative stress, autoantibodies asymptomatic individuals. In vitro glycation of human serum albumin (Gly-HSA) induces appreciable biochemical changes. Significant inhibition advanced end products (AGEs) formation was achieved using garlic extract (53.75%) epigallocatechin-3-gallate from green tea (72.5%). Increased amounts carbonyl content...
Type-2 diabetes mellitus (T2DM), is considered being a multifaceted disorder that presents major therapeutic problem. Despite the widespread efforts in managing T2DM, drug discovery therapies remain insufficient. There are several new and vital antidiabetic agents under examination of many research clusters. Computational tools have influenced at levels. Hence, this study aimed to explain molecular interactions via an silico simulation approach between Aframomum melegueta seed-derived...
Garlic has been reported to inhibit protein glycation, a process that underlies several disease processes, including chronic complications of diabetes mellitus. Biophysical, biochemical, and molecular docking investigations were conducted assess anti-glycating, antioxidant, structural protection activities garlic. Results from spectral (UV fluorescence) circular dichroism (CD) analysis helped ascertain conformation secondary structure against glycation significant extent. Further, garlic...
Aluminum chloride (AlCl
Biological materials have gained an irreplaceable position as a bio-indicator for environmental pollution with heavy metals. Human hair and nails come to play important role in this subject according the recommendations by World Health Organization (WHO). The levels of selected toxic metals (Pb, Zn, Cd, Ni) fingernails scalp autoworkers Saudi Arabia were estimated study exposure chemical pollutants samples collected from d
This study investigates unique and specific properties of the lanthanum based zinc molybdate nanocomposite material. The material was synthesized using a simple low cost “co-precipitation” method. nano materials had structural, vibrational morphological properties, determined by X-ray diffraction, fourier-transform infrared spectroscopy field emission scanning electron microscopy. nanomaterial characterised range techniques. diffraction used to determine particle size 65.7 nm disc shaped...
Heat shock proteins (HSPs) are cytoprotective against stressful conditions, as in the case of cancer cell metabolism. Scientists proposed that HSP70 might be implicated increased survival. This study aimed to investigate (HSPA4) gene expression signature patients with renal carcinoma (RCC) correlation subtype, stage, grade, and recurrence, combining both clinicopathological silico analysis approaches. One hundred thirty archived formalin-fixed paraffin-embedded samples, including 65 RCC...