A5072433554- Parasites and Host Interactions
- Research on Leishmaniasis Studies
- Heat shock proteins research
- Parasite Biology and Host Interactions
- thermodynamics and calorimetric analyses
- Effects of Radiation Exposure
- Click Chemistry and Applications
- Monoclonal and Polyclonal Antibodies Research
- RNA and protein synthesis mechanisms
- ATP Synthase and ATPases Research
- Chemical Synthesis and Analysis
- Cancer-related Molecular Pathways
- Amoebic Infections and Treatments
- Biochemical and Molecular Research
- Radiopharmaceutical Chemistry and Applications
- Enzyme Structure and Function
- Endoplasmic Reticulum Stress and Disease
- Field-Flow Fractionation Techniques
- Enzyme function and inhibition
- Immune Response and Inflammation
- Child Nutrition and Water Access
- Advanced biosensing and bioanalysis techniques
- Cancer, Hypoxia, and Metabolism
- Immune Cell Function and Interaction
- Transgenic Plants and Applications
University of Johannesburg
2020-2024
University of Zululand
2016-2020
Major histocompatibility complex class 1 chain-related gene sequence A is a polymorphic found at about 46.6 kb centromeric to HLA-B. It encodes transmembrane protein, which non-classical human leukocyte antigen whose expression normally induced by stress conditions like cancer and viral infections. The of MIC-A leads the activation NKG2D receptors natural killer T cells, leading generation innate immune response that can easily eliminate/cleanse tumour cells other express protein. Several...
Background: Acacia senegal (Fabaceae) Wild is a leguminous tree with economic values, but its leaves are under-utilised. Objective: To investigate the phytochemical constituents and antioxidant potential of crude extracts from A. Senegal's leaves. Methods: Methanol acetone were prepared by maceration using organic solvents, methanol respectively. Qualitative quantitative analysis evaluated Association Agricultural Chemist (AOAC) protocols. Antioxidant activities determined 2,...
Schistosomiasis is the most severe water-borne disease in tropics and subtropics, infecting more than 252 million people worldwide, but prevalent Sub-Saharan Africa. Reduced efficacy of Praziquantel, gold standard treatment against disease, associated reports drug resistance have diminished confidence drug, prompting efforts toward developing alternative or improved forms medication. The Universal Stress G4LZI3 protein has been identified as a potential 'lead' molecule. This manuscript...
Purpose: Universal stress protein (USP) from Schistosoma mansoni, designated as G4LZI3, waspreviously hypothesised a druggable target and vaccine candidate for human schistosomiasis.The purpose of this study is to characterize purified recombinant G4LZI3 preliminarily forsubsequent structural characterization, which will provide baseline data futurefunctional studies the discovery, design development new schistosomal drugs thetreatment, control elimination schistosomiasis. Methods:...
For decades, Praziquantel has been the undisputed drug of choice for all schistosome infections, but rising concerns due to unelucidated mechanism action and unavoidable reports emerging resistant strains necessitated need alternative treatment drug. Moreover, current apprehension reinforced by total dependence on hence, search novel effective anti-schistosomal drugs.This study made use bioinformatic tools determine structural binding Universal G4LZI3 Stress Protein (USP) in complex with ten...
Core-splicing proteins such as small nuclear ribonucleoprotein polypeptide G (SNRPG) and retinoblastoma-binding protein 6 (RBBP6) have been in the spotlight for years because of their regulatory functions mRNA processing active engagement carcinogenesis tumour growth. Varied forms cancer shown to exhibit different amounts expression two proteins. RBPP6 has linked liver, lung, breast, colon, cervical carcinomas, while SNRGP found malignancies prostate, colon. Suggestive evidence postulated...