Control of postprandial hyperglycemia is crucial in the management diabetes mellitus. Despite use current hypoglycemic drugs, incidence and related diseases continue to increase. This study aimed at evaluating vivo antihyperglycemic activity methyl-3β-hydroxylanosta-9,24-dien-21-oate (RA-3), a lanosteryl triterpene isolated, characterized from Protorhus longifolia stem bark. Spectroscopic data analysis was used establish verify structure triterpene. The evaluated an STZ-induced rat model....

The methanolic and aqueous extracts of Garcinia kola seeds were screened for their anti-Vibrio activities against 50 Vibrio isolates obtained from wastewater final effluents in the Eastern Cape Province, South Africa. crude at 10 mg/mL exhibited appreciable inhibitory most test isolates, with zones inhibition ranging 10-19 mm methanol extract 8-15 extracts. minimum concentrations (MIC) varied 0.313 to 2.5 while that was all susceptible isolates. Rate kill assay three selected species showed...

Listeriosis is a fatal disease caused by pathogenic Listeria bacteria and it most prevalent in immune-compromised individuals. The increase numbers of individuals against background antibiotic resistance, limits listeriosis treatment options. This therefore calls for research into substitute treatments, which, medicinal plants derived compounds offer viable alternative.

Type 2 diabetes remains one of the leading causes death worldwide. Persistent hyperglycemia within a diabetic state is implicated in generation oxidative stress and aggravated inflammation that responsible for accelerated modification pancreatic beta cell structure. Here we investigated whether lanosteryl triterpene, methyl-3β-hydroxylanosta-9,24-dien-21-oate (RA-3), isolated from Protorhus longifolia can improve glucose tolerance ultrastructure by reducing high fat diet...

The current rapid increase in the incidence of cardiovascular events indicates a need for discovery more effective cardioprotective agents.This study evaluated potential lanosteryl triterpene from Protorhus longifolia (Benrh.) Engl. stem bark.Spectroscopic data analysis was used to confirm structure methyl-3β-hydroxylanosta-9, 24-dien-21-oate (RA-3). effect RA-3 isoproterenol-induced myocardial injury hyperlipidemic rats investigated. Rats were divided into normal diet (ND) fed and high fat...

Partially purified fractions of the n‐hexane extract Garcinia kola seeds were obtained through column chromatography and their constituents identified use gas coupled to mass spectrometry (GC‐MS). Three by elution with benzene as mobile phase silica gel 60 stationery these named Benz1, Benz2, Benz3 in order elution. The anti Listerial activities assessed MIC determination only Benz2 found be active MIC’s ranging from 0.625 2.5 mg/mL. results GC‐MS analysis showed have 9 compounds whilst had...

Infectious diseases such as respiratory tract, skin and soft tissue infections are a cause of high morbidity rates worldwide due to the emergence antibiotic resistant bacteria. Medicinal plants Ansellia africana Platycarpha glomerata which have been reported traditionally be useful in treating these may key finding alternative treatment options. Antibacterial activities different solvent crude extracts (each at 10 mg/mL) A. (root stem) P. (leaf rhizome) were screened against respective test...

The traditional use of medicinal plants in the management sexual dysfunctions has a long history. This study investigated testicular dysfunction ameliorative effect methanolic roots extracts Maytenus procumbens and Ozoroa paniculosa butanol-induced rat model. rats respective experimental groups were orally administered with extract at 50 250 mg/kg bw, daily for 28 days. cytotoxicity was evaluated against HEK293, MCF-7, HT29 cell lines. exhibited moderate (LC 30.3–330.2 μ g/mL) to weak...

Crude methanol extracts of Garcinia kola (Heckel) seeds were screened for their antilisterial activities against 42 Listeria bacteria isolated from wastewater effluents. The extract had activity 45% the test and achieved minimum inhibitory concentrations (MICs) ranging between 0.157 0.625 mg/mL. rate kill was determined four representative species in study, results showed that highest percentage cells killed after maximum exposure time 2 h at concentration 4 × MIC value, with number being L....

We assessed the anti-Listerial activities of crude n-hexane and aqueous extracts Garcinia kola seeds against a panel 42 Listeria isolates previously isolated from wastewater effluents in Eastern Cape Province South Africa belonging to monocytogenes, grayi ivanovii species. The fraction was active 45% test bacteria with zones inhibition ranging between 8–17 mm, while 29% 8–11 mm. minimum inhibitory concentrations (MIC) were within ranges 0.079–0.625 mg/mL for extract 10 >10 extract. rate...

Dichloromethane extracts of the seeds of Garcinia kola were screened for anti-Vibrioactivities against a panel 50 Vibrio isolates comprised five different species namelyVibrio parahaemolyticus, Vibrio vulnificus, Vibrio fluvialis and Vibrio metschnikovii andVibrio sp. (not identified to specie level). The extract had activity 16 the Vibrioisolates at screening concentration 10 mg/ml, with zones inhibition ranging from 9 to15 mm. minimum inhibitory (MIC) varied between 0.313 and 0.625 while...

Background: The increase in the prevalence of multi-drug resistant bacteria has necessitated search for new antimicrobials from alternative
 sources such as traditional medicinal plants.
 Materials and Methods: agar well diffusion method was employed to determine susceptibilities four plant derived triterpenes namely,
 3β-hydroxylanosta-9, 24-dien-21-oic acid (RA5), methyl-3β-hydroxylanosta-9, 24-dien-21oate (RA3), a mixture oleanolic betulinic
 (SF1) 3β-acetonyloleanolic...

Diabetic wound infections still remain a health concern such that correct identification of bacteria is essential in monitoring the spread as well administration treatment. This study therefore focuses on isolating and identifying present diabetic wounds hospitalized patients northern KwaZulu-Natal assessing their distribution.The specimen were collected swabbed onto selective differential media. The identities presumptively ascertained through biochemical characterization (Gram-stain,...

Background and Objective: Antimicrobial susceptibility testing of bacteria recovered in diabetic wounds remains an important way monitoring infection the emergence antibiotic-resistant bacteria.Early diagnosis microbial resistance patterns is aimed to help institute appropriate antibacterial therapy improve adverse effects wound infection.This study determine phenotypic isolated from hospitalized patients.Materials Methods: disk diffusion assay was performed on 42 isolates using antibiotics...