Geraldine Lazarus

ORCID: 0000-0002-2135-9122
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About
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Research Areas
  • Crystallization and Solubility Studies
  • X-ray Diffraction in Crystallography
  • Advanced biosensing and bioanalysis techniques
  • RNA Interference and Gene Delivery
  • Phytochemistry and biological activity of medicinal plants
  • Gold and Silver Nanoparticles Synthesis and Applications
  • Nanoparticle-Based Drug Delivery
  • Metal complexes synthesis and properties
  • CRISPR and Genetic Engineering
  • Testicular diseases and treatments
  • Click Chemistry and Applications
  • Organometallic Complex Synthesis and Catalysis
  • Sperm and Testicular Function
  • Electrostatics and Colloid Interactions
  • Diverse Scientific Research Studies
  • Electrochemical Analysis and Applications
  • Asymmetric Hydrogenation and Catalysis
  • Synthesis and Characterization of Heterocyclic Compounds
  • Phytochemistry and biological activities of Ficus species
  • Natural Compounds in Disease Treatment
  • Ethnobotanical and Medicinal Plants Studies
  • Phytochemistry and Biological Activities
  • Psidium guajava Extracts and Applications
  • Nanoparticles: synthesis and applications
  • Phytochemistry and Bioactive Compounds

University of KwaZulu-Natal
2014-2018

University of Zululand
2014

Instituto de Investigación Biosanitaria de Granada
2014

Universidad de Granada
2014

New complexes [(η6-p-cymene)Ru(C5H4N-2-CH=N–Ar)X]PF6 [X = Br (1), I (2); Ar 4-fluorophenyl (a), 4-chlorophenyl (b), 4-bromophenyl (c), 4-iodophenyl (d), 2,5-dichlorophenyl (e)] were prepared, as well 3a–3e (X Cl) and the new [(η6-arene)RuCl(N-N)]PF6 (arene C6H5OCH2CH2OH, N-N 2,2′-bipyridine (4), 2,6-(dimethylphenyl)-pyridin-2-yl-methylene amine (5), 2,6-(diisopropylphenyl)-pyridin-2-yl-methylene (6); arene p-cymene, 4-(aminophenyl)-pyridin-2-yl-methylene (7)]. X-ray diffraction studies...

10.1002/zaac.201600427 article EN Zeitschrift für anorganische und allgemeine Chemie 2017-05-03

Abstract Gold nanoparticles (AuNPs) can be suitably engineered for applications in gene delivery, and as carriers of peptides proteins. They present innovative strategies therapy the treatment genetic well acquired diseases. Optimisation AuNPs binding eventual release therapeutic agent a controlled manner are crucial steps pathway to effective drug or therapy. In this study, we propose formulation cationic polymer [chitosan (Chit) poly- l -lysine (PLL)] cysteine (Cys)-coated AuNPs. These...

10.1515/ntrev-2016-0003 article EN cc-by Nanotechnology Reviews 2016-04-28

Abstract The reaction of the ruthenium arene dimers [( η 6 -arene)Ru( μ -Cl)Cl] 2 (where arene=benzene or p -cymene) with ligands 4-benzylidene-3,5-di(2′-pyridyl)-4-amino-1,2,4-triazole ( L 1 ), 2-methoxybenzylidene-3,5-di(2′-pyridyl)-4-amino-1,2,4-triazole 4-methylbenzylidene-3,5-di(2′-pyridyl)-4-amino-1,2,4-triazole 3 ) and indole-3-carbaldehyde-3,5-di(2′-pyridyl)-4-amino-1,2,4-triazole 4 in a 1:2 ratio gives new complexes -arene)RuCl(L)] + [arene=C H (with L=L 7 PF − as counter ion, Cl...

10.1515/znb-2017-0145 article EN Zeitschrift für Naturforschung B 2018-03-20

The traditional use of medicinal plants in the management sexual dysfunctions has a long history. This study investigated testicular dysfunction ameliorative effect methanolic roots extracts Maytenus procumbens and Ozoroa paniculosa butanol-induced rat model. rats respective experimental groups were orally administered with extract at 50 250 mg/kg bw, daily for 28 days. cytotoxicity was evaluated against HEK293, MCF-7, HT29 cell lines. exhibited moderate (LC 30.3–330.2 μ g/mL) to weak...

10.1155/2017/8204816 article EN Evidence-based Complementary and Alternative Medicine 2017-01-01

Purpose: To evaluate the pharmacodynamic effect and cytotoxicity of S. cordatum pulp extract in treatment gastrointestinal tract infections.Methods: The air-dried fruit pulps were ground, extracted with 100 % methanol screened for phytochemicals. Serial microdilution method was used to determine antibacterial activity against Bacillus cereus (ATCC 10102), Staphylococcus aureus 25925), Enterococcus hirae 8043), Escherichia coli 25922), Salmonella typhimurium 700030), Klebsiella pneumonia...

10.4314/tjpr.v16i6.19 article EN cc-by Tropical Journal of Pharmaceutical Research 2017-07-04

Non-viral gene delivery approaches have been extensively studied as a basic tool for intracellular transfer and therapy especially genetic aberrations including cancer. Gold nanoparticles attracted strong biomedical interest drug/gene due to their low toxic nature, surface plasmon resonance capability of increasing the stability payload. In present study synthesis photoluminescent consisting gold core coated with polyethyleneimine, poly-L-lysine, cysteine chitosan is reported. These...

10.1016/s1525-0016(16)33774-1 article EN cc-by-nc-nd Molecular Therapy 2015-05-01
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