A5025957478- Adipose Tissue and Metabolism
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Diet and metabolism studies
- Muscle metabolism and nutrition
- Mitochondrial Function and Pathology
- Obesity, Physical Activity, Diet
- Genetics and Physical Performance
- Sirtuins and Resveratrol in Medicine
- Fatty Acid Research and Health
- Cardiovascular and exercise physiology
- Pregnancy-related medical research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Exercise and Physiological Responses
- Childhood Cancer Survivors' Quality of Life
- ATP Synthase and ATPases Research
- Metabolomics and Mass Spectrometry Studies
- Drug Transport and Resistance Mechanisms
- Metabolism, Diabetes, and Cancer
- Mesenchymal stem cell research
- Liver Disease Diagnosis and Treatment
East Carolina University
2021-2024
Abstract Maternal exercise (ME) has been established as a useful non‐pharmacological intervention to improve infant metabolic health; however, mechanistic insight behind these adaptations remains mostly confined animal models. Infant mesenchymal stem cells (MSCs) give rise tissues (e.g., skeletal muscle), and remain involved in mature tissue maintenance. Importantly, maintain characteristics of an offspring donor provide model for the investigation mechanisms health improvements. We used...
Abstract Context Maternal exercise positively influences pregnancy outcomes and metabolic health in progeny; however, data regarding the effects of different modes prenatal on offspring phenotype is lacking. Objective To elucidate maternal umbilical cord derived mesenchymal stem cell (MSC) metabolism. Design Randomized controlled trial. Setting Clinical research facility. Patients Healthy females between 18 35 years age <16 weeks’ gestation. Intervention Women were randomized to...
Resveratrol, a natural polyphenol compound contained in numerous plants, has been proposed as treatment for obesity-related disease processes such insulin resistance. However, humans there are conflicting results concerning the efficacy of resveratrol improving action; purpose present study was to determine whether obesity status (lean, severely obese) affects response human skeletal muscle. Primary muscle cells were derived from biopsies obtained age-matched lean and insulin-resistant women...
Abstract Context Recent preclinical data suggest exercise during pregnancy can improve the metabolic phenotype not only of mother, but developing offspring as well. However, investigations in human are lacking. Objective To characterize effect maternal aerobic on offspring’s mesenchymal stem cells (MSCs). Design Randomized controlled trial. Setting Clinical research facility. Patients Healthy female adults between 18 and 35 years age ≤ 16 weeks’ gestation. Intervention Mothers were...
Preclinical rodent and nonhuman primate models investigating maternal obesity have highlighted the importance of intrauterine environment in development insulin resistance offspring; however, it remains unclear if these findings can be translated to humans. To investigate possible effects humans, we isolated mesenchymal stem cells (MSCs) from umbilical cord tissue infants born mothers normal weight or with obesity. Insulin-stimulated glycogen storage was determined MSCs undergoing myogenesis...
Abstract Objective Rates of pediatric obesity are continuously rising and likely to translate into a high incidence metabolic disease later in life. Maternal exercise (ME) has been established as useful non-pharmacological intervention improve infant health; however, mechanistic insight behind these adaptations remains mostly confined animal models. Infant mesenchymal stem cells (MSCs) give rise tissues (e.g., skeletal muscle), remain involved mature tissue maintenance. Importantly, maintain...
Rates of pediatric obesity are continuously rising and likely to translate into high incidence metabolic disease later in life. Maternal exercise during pregnancy has been established as a useful non-pharmacological intervention improve infant health; however, mechanistic insight behind these adaptations remains mostly confined animal models. Infant mesenchymal stem cells (MSCs) give rise multitude peripheral tissue (e.g., skeletal muscle) remain involved mature repair maintenance....
<p> </p> <p>Preclinical rodent and non-human primate models investigating maternal obesity have highlighted the importance of intrauterine environment for development insulin resistance in offspring; however, it remains unclear if these findings can be translated to humans. To investigate possible effects humans, we isolated mesenchymal stem cells (MSCs) from umbilical cord tissue infants born mothers normal weight (NW) or with (Ob). Insulin stimulated glycogen storage was...
<p> </p> <p>Preclinical rodent and non-human primate models investigating maternal obesity have highlighted the importance of intrauterine environment for development insulin resistance in offspring; however, it remains unclear if these findings can be translated to humans. To investigate possible effects humans, we isolated mesenchymal stem cells (MSCs) from umbilical cord tissue infants born mothers normal weight (NW) or with (Ob). Insulin stimulated glycogen storage was...
PURPOSE: Aerobic exercise in nonpregnant women has been shown to enhance certain aspects of the metabolic phenotype, including glucose and lipid handling. Recent preclinical data suggests during pregnancy can improve phenotype not only mother, but developing offspring as well. We utilized an in-utero cell culture model (mesenchymal stem cells, MSCs) characterize effects maternal aerobic on offspring. METHODS: Expecting mothers, were randomized into one two groups: (AE) or non-exercise...