A5086243359- Gestational Diabetes Research and Management
- Birth, Development, and Health
- Cardiovascular Issues in Pregnancy
- Obesity, Physical Activity, Diet
- Pregnancy-related medical research
- Adipose Tissue and Metabolism
- Heart Rate Variability and Autonomic Control
- Pregnancy and preeclampsia studies
- Congenital Heart Disease Studies
- Adolescent and Pediatric Healthcare
- Cardiovascular Function and Risk Factors
- Neonatal and fetal brain pathology
- Maternal Mental Health During Pregnancy and Postpartum
- Mitochondrial Function and Pathology
- Infant Development and Preterm Care
- Fatty Acid Research and Health
- Diet and metabolism studies
- Neuroscience of respiration and sleep
- ATP Synthase and ATPases Research
- Cardiovascular Effects of Exercise
- Physical Activity and Health
- Cardiomyopathy and Myosin Studies
- Cardiovascular and exercise physiology
- Mesenchymal stem cell research
- Child Nutrition and Feeding Issues
East Carolina University
2016-2025
Tygerberg Hospital
2025
Stellenbosch University
2025
Beijing Obstetrics and Gynecology Hospital
2024
Greenville College
2018-2024
Illinois State University
2021-2024
University of Southern Indiana
2021-2023
GTx (United States)
2023
University of Almería
2022
East Central University
2020
Abstract Maternal exercise (ME) has been established as a useful non‐pharmacological intervention to improve infant metabolic health; however, mechanistic insight behind these adaptations remains mostly confined animal models. Infant mesenchymal stem cells (MSCs) give rise tissues (e.g., skeletal muscle), and remain involved in mature tissue maintenance. Importantly, maintain characteristics of an offspring donor provide model for the investigation mechanisms health improvements. We used...
Abstract Context Maternal exercise positively influences pregnancy outcomes and metabolic health in progeny; however, data regarding the effects of different modes prenatal on offspring phenotype is lacking. Objective To elucidate maternal umbilical cord derived mesenchymal stem cell (MSC) metabolism. Design Randomized controlled trial. Setting Clinical research facility. Patients Healthy females between 18 35 years age <16 weeks’ gestation. Intervention Women were randomized to...
Purpose Our previous research found lower fetal HR and increased variability (HRV) in women who exercised during pregnancy. This finding is similar to the adult heart training response at rest due aerobic exercise. Dose–response associations have been between physical activity cardiorespiratory fitness adults. Therefore, our objective was determine whether there a dose–response relationship maternal HR, HRV, sympathovagal balance. Methods Pregnant completed questionnaire magnetocardiogram...
Abstract Objective Assess the effects of supervised, prenatal aerobic exercise intervention on 1‐month‐old neonatal morphometry. Methods Secondary data analyses a 24+ week, randomized controlled trial in pregnant women between 2015 and 2018 were performed. Eligibility criteria included women: <16 weeks gestation, singleton pregnancy, aged 18–40 years, body mass index 18.5–35.00 kg∙m 2 . Eligible ( n = 128) randomly assigned moderate‐intensity group 68) or nonexercising 60) consisting...
As thresholds for the diagnosis of gestational diabetes mellitus (GDM) become lower, and prevalence obesity in society rises, more pregnant women will be diagnosed with GDM hypertension. Both conditions hold dangers mother baby. Our objective was to properly describe this association. This retrospective audit conducted at Obstetric High-Risk Clinic Tygerberg Academic Hospital, Cape Town, South Africa. All patients from 01/01/19 - 31/12/19 were included. The primary aim determine incidence,...
Offspring exposed to metformin treatment for gestational diabetes mellitus (GDM) experience altered growth patterns that increase the risk developing cardiometabolic diseases later in life. The adaptive cellular mechanisms underlying these remain unclear. Therefore, objective of this study was determine if chronic utero exposure associated with GDM elicits infant metabolic adaptations. In a cross-sectional design, 22 pregnant women diagnosed and treated exclusively (Met; n=12) or diet (A1DM;...
We explored whether maternal exercise during pregnancy moderates the effect of fetal breathing movements on cardiac autonomic control assessed by metrics heart rate (HR) and variability (HRV). Thirty women were assigned to Exercise or Control group (n=15/group) based modifiable physical activity questionnaire (MPAQ). Magnetocardiograms (MCG) recorded using a dedicated biomagnetometer. Periods apnea identified diaphragmatic magnetomyogram (dMMG) as marker. MCG R-waves marked. Metrics HR HRV...
Pregnancy is associated with an increased sympathetic state, which can be exacerbated by gestational conditions. Research has shown that exercise during pregnancy lowers heart rate (HR) and attenuate the symptoms of conditions control. However, changes in maternal autonomic function response to have not been reported across multiple time points pregnancy. This analysis designed address this gap.To determine if throughout gestation improves cardiac nervous system functioning, as evidenced...
The extent of the benefits exercise training during pregnancy on maternal, fetal, and neonatal health outcomes has not been sufficiently addressed. While aerobic determined as safe efficacious throughout pregnancy, effects other modes fetal development well any continued for neonate, especially with regards to cardiovascular function, is largely unknown. In ENHANCED by Mom study we aim determine different (aerobic, circuit, resistance) childhood controlling individual programs assessing each...
ABSTRACT Purpose To determine the effects of exercise during pregnancy on neuromotor development 1-month-old offspring. We hypothesized that aerobic would be associated with higher scores in infants at 1 month age, based standard pediatric assessment skills. Methods Seventy-one healthy, pregnant women between 18 and 35 yr were randomly assigned to either intervention or no (control) group. Women group performed 50 min moderate-intensity, supervised exercise, three times per week; those...
It has been shown that short-term direct interaction between maternal and fetal heart rates may take place this is affected by the rate of respiration. The aim study was to determine effect aerobic exercise during pregnancy on occurrence fetal-maternal synchronization. Methods In 40 pregnant women at 36th week gestation, 21 whom exercised regularly, we acquired 18 min. RR interval time series obtained simultaneously in mothers their fetuses from magnetocardiographic recordings. two groups...
Abstract Background Prenatal exercise improves birth outcomes, but research into dose–response effects is limited. Methods This study a retrospective, secondary analysis of pooled data from three blinded, prospective, randomized controlled trials. frequency, intensity, type, time, and volume (FITT‐V) were assessed in supervised sessions throughout pregnancy. Gestational age (GA), neonatal resting heart rate (rHR), morphometrics (body circumferences, weight‐to‐length ponderal index) Apgar...
Public spending on parks in racial/ethnic minority areas lags behind more affluent areas. Limited resources could result poor quality turn creating additional barriers to physical activity. However, the of these has not been adequately investigated. The purpose this study was conduct an empirical examination associations between park characteristics and demographics residents living around park. Physical Activity Resource Assessment instrument used evaluate quantity features amenities 68...
African Americans, when compared with Caucasians, display greater insulin resistance in skeletal muscle. Differences substrate utilization have been proposed as a factor for this health disparity; however, it remains unknown how early these differences manifest. Using infant umbilical cord-derived mesenchymal stem cells, we tested vitro glucose and fatty acid oxidation differences. Myogenically differentiated MSCs from American offspring higher rates of incomplete oxidation.
In adults, skeletal muscle insulin sensitivity (SI ) and fatty acid oxidation (FAO) are linked with a predisposition to obesity. The current study aimed determine the effects of maternal exercise on model infant tissue (differentiated umbilical cord mesenchymal stem cells [MSCs]) SI FAO analyzed for associations body composition.Females <16 weeks' gestation were randomized either 150 min/wk moderate-intensity aerobic, resistance, or combination nonexercising control. At delivery, MSCs...