A5034727328- Adipose Tissue and Metabolism
- Gestational Diabetes Research and Management
- Birth, Development, and Health
- Infant Nutrition and Health
- Cardiovascular Disease and Adiposity
- Breastfeeding Practices and Influences
- Obesity, Physical Activity, Diet
- Regulation of Appetite and Obesity
- Diet and metabolism studies
- Assisted Reproductive Technology and Twin Pregnancy
- Plant Micronutrient Interactions and Effects
- Bariatric Surgery and Outcomes
- Sirtuins and Resveratrol in Medicine
- Digestive system and related health
- Mesenchymal stem cell research
- Obstructive Sleep Apnea Research
- Fatty Acid Research and Health
- Eating Disorders and Behaviors
- Phytase and its Applications
- Tissue Engineering and Regenerative Medicine
- Epigenetics and DNA Methylation
- Trace Elements in Health
- Gut microbiota and health
- Neuropeptides and Animal Physiology
University of Rochester Medical Center
2021-2022
Gastroenterology Center of Connecticut
2018
University of Colorado Anschutz Medical Campus
2016-2017
University of Colorado Denver
2014-2017
Quinnipiac University
2016
Johns Hopkins University
2009-2011
Maternal obesity increases the risk for pediatric obesity; however, molecular mechanisms in human infants remain poorly understood. We hypothesized that mesenchymal stem cells (MSCs) from born to obese mothers would demonstrate greater potential adipogenesis and less myogenesis, driven by differences β-catenin, a regulator of MSC commitment. MSCs were cultured umbilical cords normal-weight (prepregnancy [pp] BMI 21.1 ± 0.3 kg/m(2); n = 15; NW-MSCs) (ppBMI 34.6 1.0 14; Ob-MSCs). Upon...
Infants born to mothers with obesity have greater adiposity, ectopic fat storage, and are at increased risk for childhood metabolic disease compared infants of normal weight mothers, though the cellular mechanisms mediating these effects unclear.We tested hypothesis that human, umbilical cord-derived mesenchymal stem cells (MSCs) from obese (Ob-MSC) versus (NW-MSC) demonstrate altered fatty acid metabolism consistent adult obesity. In infant MSCs undergoing myogenesis in vitro, we measured...
Maternal obesity is a global health problem that increases offspring risk. The metabolic pathways underlying early developmental programming in human infants at risk for remain poorly understood, largely due to barriers fetal/infant tissue sampling. Utilizing umbilical cord–derived mesenchymal stem cells (uMSC) from of normal weight and obese mothers, we tested whether energy metabolism gene expression differ differentiating uMSC myocytes adipocytes, relation maternal exposures and/or...
The intrauterine period is a critical time wherein developmental exposure can influence risk for chronic disease including childhood obesity. Using umbilical cord-derived mesenchymal stem cells (uMSC) from offspring born to normal-weight and obese mothers, we tested the hypothesis that changes in infant body composition over first 5 months of life correspond with differences cellular metabolism transcriptomic profiles at birth. Higher long-chain acylcarnitine concentrations, lipid transport...
Exposure to maternal obesity may promote metabolic dysfunction in offspring. We used infant mesenchymal stem cells (MSCs) experimentally examine cellular mechanisms of intergenerational health transmission. Our earlier reports show MSCs collected from infants mothers with had a dichotomous distribution efficiency; they were either efficient (Ef-Ob) or inefficient (In-Ob) respect fatty acid oxidation (FAO). Here, we sought determine if this was due primary defect FAO. Accordingly, measured...
The cellular mechanisms whereby excess maternal nutrition during pregnancy increases adiposity of the offspring are not well understood. However, nicotinamide (NAM), a fundamental micronutrient that is important in energy metabolism, has been shown to regulate adipogenesis through inhibition SIRT1. Here we tested three novel hypotheses: 1) NAM adipogenic response human umbilical cord tissue-derived mesenchymal stem cells (MSCs) SIRT1 and PPARγ pathway; 2) lipid potentiates NAM-enhanced...
Preclinical rodent and nonhuman primate models investigating maternal obesity have highlighted the importance of intrauterine environment in development insulin resistance offspring; however, it remains unclear if these findings can be translated to humans. To investigate possible effects humans, we isolated mesenchymal stem cells (MSCs) from umbilical cord tissue infants born mothers normal weight or with obesity. Insulin-stimulated glycogen storage was determined MSCs undergoing myogenesis...
4‐hydroxynonenol (HNE; a protein adduct product of lipid peroxidation) may serve as novel marker oxidative stress in human milk (HM). We investigated the determinants HNE HM and relationships between maternal BMI, cytokines, infant growth. Anthropometry was performed on 36 mothers their healthy term (37‐42 weeks) exclusively breastfed infants at T 1 (2 weeks), 2 (4 months) 3 (6 months). collected for macronutrient, HNE, IL‐6, IL‐8, TNF‐α analysis. Infants gaining more than 0.66...
Excess infant weight and fat gain incur risk of later obesity. We investigated whether insulin or the orexigenic hormone, ghrelin, in human milk (HM) differed by maternal BMI these hormones associated with adipose deposition. 26 normal (NW) 23 overweight (OW) breastfeeding women provided fasted HM samples at 2‐wks (T 1 ), 2‐mos 2 4‐mos 3 ) for analysis insulin, fat. Fasting blood was collected T ghrelin. Infant body composition measured (by PeaPod TM . OW mothers exhibited higher (p=0.04)...
<p> </p> <p>Preclinical rodent and non-human primate models investigating maternal obesity have highlighted the importance of intrauterine environment for development insulin resistance in offspring; however, it remains unclear if these findings can be translated to humans. To investigate possible effects humans, we isolated mesenchymal stem cells (MSCs) from umbilical cord tissue infants born mothers normal weight (NW) or with (Ob). Insulin stimulated glycogen storage was...
<p> </p> <p>Preclinical rodent and non-human primate models investigating maternal obesity have highlighted the importance of intrauterine environment for development insulin resistance in offspring; however, it remains unclear if these findings can be translated to humans. To investigate possible effects humans, we isolated mesenchymal stem cells (MSCs) from umbilical cord tissue infants born mothers normal weight (NW) or with (Ob). Insulin stimulated glycogen storage was...