A5087334709- RNA Interference and Gene Delivery
- Nanomaterials for catalytic reactions
- Marine and Coastal Ecosystems
- Phytochemistry and Bioactivity Studies
- Chemical Reactions and Isotopes
- Bioactive Compounds and Antitumor Agents
- Fungal Biology and Applications
- Ethnobotanical and Medicinal Plants Studies
- Plant-Derived Bioactive Compounds
- Traditional and Medicinal Uses of Annonaceae
- Lipid Membrane Structure and Behavior
- Toxin Mechanisms and Immunotoxins
- Natural product bioactivities and synthesis
- Marine Sponges and Natural Products
- Marine Bivalve and Aquaculture Studies
- Aquatic life and conservation
- Synthesis and bioactivity of alkaloids
University of the Western Cape
2020-2025
The use of natural products as chemotherapeutic agents is well established; however, many these are associated with undesirable side effects, including high toxicity and instability. Furthermore, the development drug resistant cancers makes search for new anticancer lead compounds a priority. In this study, extraction an Ircinia sp. sponge resulted in isolation inseparable mixture (7E,12E,20Z)-variabilin (1) (7E,12Z,20Z)-variabilin (2) structural assignment was established using standard 1D...
Background/Objectives: Tuberculosis remains a major public health crisis, and it is imperative to search for new antimycobacterial drugs. Natural products, including medicinal macrofungi, have been used as sources the discovery of pharmaceuticals; however, research on their activity limited. This study aimed isolate identify bioactive compound responsible activity, thereby expanding limited knowledge regarding antimicrobial compounds present in Gymnopilus junonius. Methods: Bioassay-guided...
Asparagopsis taxiformis macroalgae can potentially reduce methane emissions when fed to ruminants, thus reducing the emission of greenhouse gasses into atmosphere. Literature indicates water temperatures above 24 °C limit A. taxiformes growth rates during culture, however, it grows wild in Seychelles where range from 25 31.5 °C. The feasibility cultivating local strain was investigated, focusing on at higher and bromoform content, compound responsible for reduction. Two tetrasporophyte...
The use of natural products as chemotherapeutic agents is well established. However, many are associated with undesirable side effects, including high toxicity and instability. Previous reports on the cytotoxic activity pyrroloiminoquinones isolated from Latrunculid sponges against cancer cell lines revealed extraordinary at IC50 77nM for discorhabdins. Their general lack selectivity normal lines, however, precludes further development. In this study, extraction a South African sponge...
A further chemical investigation of the butanol extract leaves from South African medicinal plant Sutherlandia frutescens led to isolation eight previously unreported saponins (1−8), together with known sutherlandiosides A−D. Their structures were established by spectroscopic (1D and 2D NMR) analyses, CD, optical rotation, mass spectrometry, as well conversions. The isolates screened for their cytotoxic activity against MCF-7 human breast cancer cell line, although no significant was...