A5024117256- Viral-associated cancers and disorders
- Cervical Cancer and HPV Research
- Global Cancer Incidence and Screening
- Cancer Diagnosis and Treatment
- HIV/AIDS Research and Interventions
- Cancer and Skin Lesions
- Lymphoma Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Cancer survivorship and care
- Diversity and Career in Medicine
- Economic and Financial Impacts of Cancer
- HIV/AIDS drug development and treatment
- Multiple and Secondary Primary Cancers
- Colorectal Cancer Screening and Detection
- Chronic Disease Management Strategies
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Dental Education, Practice, Research
- Breast Lesions and Carcinomas
- Male Breast Health Studies
- BRCA gene mutations in cancer
- Cardiac, Anesthesia and Surgical Outcomes
- Hip and Femur Fractures
- Global Health and Surgery
- Hedgehog Signaling Pathway Studies
University of Zululand
2023-2024
University of KwaZulu-Natal
2023-2024
University of the Witwatersrand
2018-2023
Johannesburg Hospital
2018-2023
Africa Health Research Institute
2021-2022
Helen Joseph Hospital
2019
University of Pretoria
2016
Background. Monitoring quality indicators to improve breast cancer care is well established in high-income countries. This the first evaluation of diagnostic and surgical for initial benchmarking South Africa (SA). Objective. To measure adherence rates among women with SA. Methods. Ten were evaluated 3 545 patients across four SA units using a shared electronic patient record system. Data differences between determined. The effect HIV status on was assessed by multivariate Poisson regression...
In some countries of sub-Saharan Africa, the prevalence HIV exceeds 20%; in South 20.4% people are living with HIV. We examined impact infection on overall survival (OS) women nonmetastatic breast cancer (BC) enrolled African Breast Cancer and Outcomes (SABCHO) study. recruited newly diagnosed BC at six public hospitals from 1 July 2015 to 30 June 2019. Among stages I-III BC, we compared those without sociodemographic, clinical, treatment factors. analyzed OS using multivariable Cox...
Breast cancer is a heterogeneous disease with different gene expression profiles, treatment options and outcomes. In South Africa, tumors are classified using immunohistochemistry. high-income countries multiparameter genomic assays being utilized implications for tumor classification treatment.In cohort of 378 breast patients from the SABCHO study, we investigated concordance between samples by IHC PAM50 assay.IHC as ER-positive (77.5%), PR-positive (70.6%), HER2-positive (32.3%). These...
Abstract Background Breast cancer survival in South Africa is low, but when diagnosed with breast cancer, many women also have other chronic conditions. We investigated the impact of multimorbidity (≥ 2 conditions) on overall among Africa. Methods Between 1 July 2015 and 31 December 2019, we enrolled newly at six public hospitals participating African Cancer HIV Outcomes (SABCHO) Study. examined seven conditions (obesity, hypertension, diabetes, HIV, cerebrovascular diseases (CVD),...
Objective In low- and middle-income countries (LMICs), advanced-stage diagnosis of breast cancer (BC) is common, this contributes to poor survival. Understanding the determinants stage at will aid in designing interventions downstage disease improve survival from BC LMICs. Methods Within South African Breast Cancers HIV Outcomes (SABCHO) cohort, we examined factors affecting histologically confirmed invasive five tertiary hospitals Africa (SA). The was assessed clinically. To examine...
In high-income settings, delays from breast cancer (BC) diagnosis to initial treatment worsen overall survival (OS). We examined how time BC initiation (TTI) impacts OS in South Africa (SA).
High-quality histopathology reporting forms the basis for treatment decisions. The quality indicator pathology reports from European Society of Breast Cancer Specialists was applied to a cohort four South African breast units.The study included 1,850 patients with invasive cancer and evaluated core biopsies 1,158 surgical specimen cross-center comparisons. A biopsy report required histologic type; tumor grade; estrogen receptor, progesterone human epidermal growth factor receptor 2 (HER2)...
Treatment decision making for patients with breast cancer increasingly depends on analysis of markers or systems estimating risk recurrence. Breast intrinsic subtypes and recurrence (ROR) scores have been found to be valuable in predicting survival determining optimal treatment individual patients. We studied the association PAM50 gene expression assay HIV-positive HIV-negative patients.RNA was extracted from formalin-fixed paraffin-embedded specimens histologically confirmed invasive...
Background: Breast cancer (BC) is the most common malignancy diagnosed among women in South Africa (SA). The aggressive triple-negative breast (TNBC) subtype comprises approximately 15% of BC cases SA. SA has largest HIV-infected population world, but it unclear whether proportion patients with TNBC differs by HIV status.Methods: African Cancer and Outcomes (SABCHO) study a prospective cohort recruiting newly at six public hospitals We used SABCHO subjects recruited from 1 January 2015 to 18...
The South African Breast Cancer and HIV Outcomes prospective cohort (SABCHO) study was established to investigate survival determinants among HIV-positive HIV-negative SA women with breast cancer. This paper describes common unique characteristics of the cancer centres their participants, examining disparities in pathways diagnosis, treatment resources approaches adopted mitigate resource constraints. Johannesburg (Jhb), Soweto (Sow), Durban (Dbn) sites treat mainly urban, relatively better...