A5012052432- Global Cancer Incidence and Screening
- Breast Cancer Treatment Studies
- AI in cancer detection
- Parathyroid Disorders and Treatments
- Digital Radiography and Breast Imaging
- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Cancer Genomics and Diagnostics
- Dialysis and Renal Disease Management
- Acute Kidney Injury Research
- HIV/AIDS drug development and treatment
- Iron Metabolism and Disorders
- TGF-β signaling in diseases
- Hepatitis C virus research
- Viral-associated cancers and disorders
- Cervical Cancer and HPV Research
- Hemoglobinopathies and Related Disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- GDF15 and Related Biomarkers
- HIV Research and Treatment
- Biomarkers in Disease Mechanisms
- Erythropoietin and Anemia Treatment
- Cancer Risks and Factors
- Obesity and Health Practices
- Hepatitis B Virus Studies
University of the Witwatersrand
2015-2024
University Hospitals of Derby and Burton NHS Foundation Trust
2024
Centre International de Recherche sur le Cancer
2014-2023
University of Oxford
2023
Stanford University
2019-2020
Palo Alto University
2020
Johannesburg Hospital
2012-2017
Cancer Registry of Norway
2015
South African National Blood Service
2011
The Patients Association
1996
APOL1 variants are associated with HIV-associated nephropathy and FSGS in African Americans. The prevalence of these populations CKD HIV-1 infection has not been investigated. We determined the role 120 patients 108 controls from a South-African black population. Patients were selected on basis histology. Genotypes successfully for G1 G2 42 single nucleotide polymorphisms, including 18 ancestry informative markers, 116 (96.7%; 38 nephropathy, 39 HIV-positive CKD, HIV-negative CKD), (100%)....
Advanced stage at diagnosis contributes to low breast cancer survival rates in sub-Saharan Africa. Living far from health services is known delay presentation, but the effect of residential distance hospital, radius which this sets and women most affected have not been quantified. In a periurban South African setting, we examined geographic information system (GIS)-measured straight-line distance, patient's residence diagnostic on 1,071 public-sector patients diagnosed during 2006-2012....
Since October 2005, a total of 2,921,561 blood donations have been screened by the South African National Blood Service for hepatitis B virus (HBV) individual-donation nucleic acid testing (ID-NAT). Over 4 years, 149 surface antigen-negative acute-phase HBV NAT-positive were identified (1:19,608). The lookback program one probable transmission.The complete genomes isolated from donor and recipient sequenced, cloned, analyzed phylogenetically. window period (WP) transmission risk was...
Abstract Coral‐derived calcium carbonate/hydroxyapatite macroporous constructs of the genus Goniopora with limited hydrothermal conversion to hydroxyapatite (7% HA / CC ) initiate induction bone formation. Which are molecular signals that pattern formation and formation? To evaluate role released ions osteoclastogenesis, 7% was pre‐loaded either 500 μg channel blocker, verapamil hydrochloride, or 240 osteoclast inhibitor, biphosphonate zoledronate, implanted in rectus abdominis muscle six...
Fluid overload is common in chronic kidney disease (CKD) patients, potentially driving inflammation and left ventricular dysfunction. We investigated the association between volume overload, inflammation, dysfunction across subgroups of CKD patients.The study included 160 participants, comprising peritoneal dialysis (PD), hemodialysis (HD), stage-3 age- sex-matched controls (40 each group). status was assessed using a body composition monitor (BCM); serum endotoxin, lipopolysaccharide...
Higher childhood cancer incidence rates are generally reported for high income countries although quality information on descriptive patterns of low or middle is limited, particularly in Sub-Saharan Africa. There a need to quantify global differences by types, and investigate whether they reflect true can be attributed under-diagnosis under-reporting. For the first time, we describe data pathology report-based National Cancer Registry South Africa 2000-2006 compare our results from Germany,...
Breast cancer is a heterogeneous disease with different gene expression profiles, treatment options and outcomes. In South Africa, tumors are classified using immunohistochemistry. high-income countries multiparameter genomic assays being utilized implications for tumor classification treatment.In cohort of 378 breast patients from the SABCHO study, we investigated concordance between samples by IHC PAM50 assay.IHC as ER-positive (77.5%), PR-positive (70.6%), HER2-positive (32.3%). These...
Receptor-defined breast cancer proportions vary across Africa. They have important implications for survival prospects and research priorities.
Inter-women and intra-women comparisons of mammographic density (MD) are needed in research, clinical screening applications; however, MD measurements influenced by mammography modality (screen film/digital) digital image format (raw/processed). We aimed to examine differences assessed on these types. obtained 1294 pairs images saved both raw processed formats from Hologic General Electric (GE) direct systems a Fuji computed radiography (CR) system, 128 screen-film CR-digital consecutive...
Background: Molecular analysis has shown that breast carcinomas can be classified into several intrinsic subtypes, with implications for management and prognosis. In the majority of pathology laboratories molecular each case is not possible immunohistochemistry used subtyping. This includes hormone receptors as well HER2-neu Ki67. The methodology interpretation proliferation index using Ki67 remains an area uncertainty. We investigated degree agreement between different methods...
Abstract Background Early age at menarche and tall stature are associated with increased breast cancer risk. We examined whether these associations were also positively mammographic density, a strong marker of Methods Participants 10,681 breast-cancer-free women from 22 countries in the International Consortium Mammographic Density, each centrally assessed density common set epidemiologic data. Study periods for 27 studies ranged 1987 to 2014. Multi-level linear regression models estimated...
Despite ranking third as a cause of hospital-acquired acute kidney injury (AKI), iatrogenic contrast-induced nephropathy (CIN) impacts significantly on morbidity and mortality is associated with high hospital costs. In sub-Saharan Africa, the rates risk factors for CIN patient outcomes remain unexplored.We conducted prospective observational study at Charlotte Maxeke Johannesburg Academic Hospital, South from 1 July 2014 to 30 2015. Hospitalised patients undergoing computed tomography scan...
Abstract Objectives The aim of this study was to investigate cementogenesis and alveolar bone induction during in vivo periodontal tissue regeneration upon implantation h TGF ‐ β 3 furcation defects Papio ursinus evaluate the feasibility gene expression studies. Materials Methods Class II (day 0) were prepared mandibular first second molars three P. on day 30 implanted with without 75 μ g Matrigel ® matrix. On 0, 90, cementum harvested for analyses. Coral‐derived bioreactors 250 rectus...
Inflammation is a major risk factor for atherosclerosis. Genetic polymorphisms in the inflammatory cytokine genes have been associated with Because levels of cytokines are markedly elevated patients chronic kidney disease (CKD), we hypothesized that genotypic variations interleukin-6 (IL-6) gene cause systemic states and atherosclerosis South African CKD patients. 120 40 healthy controls were included. Serum IL-6 high-sensitivity C-reactive protein (hs-CRP) measured. Functional genotyped...
Our objective was to review the quality of service delivered by a national cancer information service--the British Association Cancer United Patients (BACUP)--and consider implications for future policy and practice. We used sample callers over 10-day period, responding structured postal questionnaire. The included patients, relatives, friends, general public who called with any concern relating cancer. Of 406 invited take part, 282 responded (69%). questionnaire designed evaluate callers'...
Twenty-one hepatitis B virus (HBV) isolates from the state of Haryana (North India) were studied for genotype, subgenotype, serotype distribution and precore mutations. Assays alanine aminotransminase (ALT) HBeAg performed on all samples. Genotypes, subgenotypes serotypes determined by amplification pre-S1/S2 regions followed RFLP also phylogenetic analysis amplified products. Mutations sequencing region. Twenty-four percent samples had high ALT levels 90% negative. It was observed that HBV...
Objectives Low‐dose stavudine therapy may have a lower toxicity profile compared with standard dose. A randomized controlled trial comparing these two doses of tenofovir disoproxil fumarate (tenofovir DF ) was performed to assess the effects on anthropometry, markers inflammation, and lipid glucose metabolism in B lack S outh frican patients. Methods Sixty patients were 1:1:1 either standard‐dose (30–40 mg) or low‐dose (20–30 (300 mg), each combined lamivudine efavirenz, for 48 weeks....
Alterations in whole genome expression profiles following exposure of the pneumococcus (strain 172, serotype 23F) to cigarette smoke condensate (160 μ g/mL) for 15 and 60 min have been determined using TIGR4 DNA microarray chip. Exposure CSC resulted significant (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn fontstyle="italic">0.014</mml:mn></mml:math>–0.0006) upregulation genes encoding two-component regulatory system 11...