Eunice J. van den Berg
A5027407006- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Global Cancer Incidence and Screening
- Circular RNAs in diseases
- Breast Cancer Treatment Studies
- Epigenetics and DNA Methylation
- Viral-associated cancers and disorders
- AI in cancer detection
- Molecular Biology Techniques and Applications
- Multiple and Secondary Primary Cancers
- Cervical Cancer and HPV Research
- Polyomavirus and related diseases
- Male Breast Health Studies
- BRCA gene mutations in cancer
- Analytical Methods in Pharmaceuticals
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pharmacology and Obesity Treatment
- Hormonal and reproductive studies
- Cytomegalovirus and herpesvirus research
- Fungal Infections and Studies
- CNS Lymphoma Diagnosis and Treatment
- Bacterial biofilms and quorum sensing
- Antifungal resistance and susceptibility
University of the Witwatersrand
2014-2024
National Health Laboratory Service
2013-2023
Chris Hani Baragwanath Hospital
2018-2023
Estimates of the proportion estrogen receptor negative (ERN) and triple-negative (TRN) breast cancer from sub-Saharan Africa are variable include high values. Large studies status conducted on non-archival tissue lacking this region. We identified 1218 consecutive women (91% black) diagnosed with invasive 2006–2012 at a public hospital in Soweto, South Africa. Immunohistochemistry based ER, progesterone (PR) human epidermal factor 2 (HER2) receptors were assessed diagnosis pre-treatment...
In the low-income HIV-endemic regions of sub-Saharan Africa, malignancies related to HIV have long been recognized as a major public health problem. However, epithelial associated with older age, such breast cancer, are also rising dramatically in those regions. We compared consecutive HIV-positive and -negative black women diagnosed cancer at large hospital Soweto, South on year diagnosis, stage, grade, receptor status, grouped patients by CD4 cell counts. computed prevalence ratios...
An unmet need in low-resource countries is an automated breast cancer detection assay to prioritize women who should undergo core biopsy and pathologic review. Therefore, we sought identify validate a panel of methylated DNA markers discriminate between benign lesions using cells obtained by fine-needle aspiration (FNA).Experimental Design: Two case-control studies were conducted comparing tissue identified from clinical repositories the United States, China, South Africa for marker...
Abstract The low overall survival rates of patients with breast cancer in sub-Saharan Africa (SSA) are driven by regionally differing tumor biology, advanced stages at diagnosis, and limited access to therapy. However, it is not known whether regional differences the composition microenvironment (TME) exist affect patients’ prognosis. In this international, multicentre cohort study, 1,237 formalin-fixed, paraffin-embedded samples, including samples “African Breast Cancer-Disparities Outcomes...
Tuberculosis (TB) remains endemic in South Africa. The spine, hip, and knee joints are common extra-pulmonary TB sites. Sound history taking, clinical examination, basic laboratory pathological tests remain key important steps osteoarticular diagnosis. In our resources-stricken context cost is everything, if we can make a diagnosis cheaply that would go long way. diagnostic yield of standard compared to real-time polymerase chain reaction (PCR) for single orthopaedic unit has not been...
Hepatosplenic T-cell lymphoma (HSTCL) is a rare type of Non-Hodgkin Lymphoma (NHL), grouped under the mature or peripheral lymphomas. It characterised by extranodal infiltration and proliferation malignant T-cells within sinusoids liver, sinuses red pulp spleen, bone marrow. The tumour cells express CD2 CD3, but are CD4, CD5 CD8 negative clonally restricted gamma-delta (or less commonly alpha-beta) receptor. disease has an aggressive clinical course associated with poor prognosis. We...
Despite widespread access to antiretroviral therapy (ART), the burden of advanced HIV disease in South Africa is high. This translates into an increased risk AIDS-related opportunistic infections, including invasive mycoses.Using a limited number non-culture-based diagnostic assays, we aimed determine prevalence mycoses and tuberculosis among hospitalised adults with very (CD4 counts < 100 cells/µL) at large academic hospital. We conducted interviews prospective medical chart reviews....
High-quality histopathology reporting forms the basis for treatment decisions. The quality indicator pathology reports from European Society of Breast Cancer Specialists was applied to a cohort four South African breast units.The study included 1,850 patients with invasive cancer and evaluated core biopsies 1,158 surgical specimen cross-center comparisons. A biopsy report required histologic type; tumor grade; estrogen receptor, progesterone human epidermal growth factor receptor 2 (HER2)...
Treatment decision making for patients with breast cancer increasingly depends on analysis of markers or systems estimating risk recurrence. Breast intrinsic subtypes and recurrence (ROR) scores have been found to be valuable in predicting survival determining optimal treatment individual patients. We studied the association PAM50 gene expression assay HIV-positive HIV-negative patients.RNA was extracted from formalin-fixed paraffin-embedded specimens histologically confirmed invasive...
Disseminated
<p>Figure S1: Consort diagram of the analyzed samples</p>
<p>Figure S1: Consort diagram of the analyzed samples</p>
<p>Figure S2: TILs in SSA</p>
<p>Figure S3: Immune cell subpopulations in SSA</p>
<p>Figure S2: TILs in SSA</p>
<p>Figure S4:PD-L1 expression and cytotoxicity</p>
<p>Figure S3: Immune cell subpopulations in SSA</p>
<p>Figure S5: MHC I expression in SSA</p>
<p>Figure S4:PD-L1 expression and cytotoxicity</p>
<p>Figure S5: MHC I expression in SSA</p>
<p>Figure S6: Multivariate Cox regression analysis of patient's survival.</p>
<p>Figure S6: Multivariate Cox regression analysis of patient's survival.</p>