A5028322758- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Chronic Lymphocytic Leukemia Research
- Blood groups and transfusion
- Hematological disorders and diagnostics
- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Platelet Disorders and Treatments
- Chronic Myeloid Leukemia Treatments
- Clinical Laboratory Practices and Quality Control
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hemophilia Treatment and Research
- Immunodeficiency and Autoimmune Disorders
- HIV Research and Treatment
- Hemostasis and retained surgical items
- Hepatitis C virus research
- Parvovirus B19 Infection Studies
- Digital Imaging for Blood Diseases
- Bone and Joint Diseases
- Hepatitis B Virus Studies
- Blood Coagulation and Thrombosis Mechanisms
- Erythrocyte Function and Pathophysiology
- T-cell and Retrovirus Studies
- Herpesvirus Infections and Treatments
- Venous Thromboembolism Diagnosis and Management
National Health Laboratory Service
2016-2025
University of the Witwatersrand
2015-2024
Chris Hani Baragwanath Hospital
2015-2023
National Public Health Laboratory
2016
University of Santo Tomas
2006
Bristol-Myers Squibb (United States)
2006
Ankara University
2006
Henry Dunant Hospital
2006
University Health Network
2006
Limited availability of diagnostic tests in low-resource settings hampers the diagnosis and classification diffuse large B-cell lymphoma (DLBCL). A study was performed to assess use resources for classifying DLBCL South Africa (SA) using 'essential' 'desirable' investigations as per published guidelines. record review 74 patients newly diagnosed with by tissue biopsy at National Health Laboratory Service (NHLS) Johannesburg between 1 January 2019 31 December 2022. The immunohistochemistry...
Plasmablastic lymphoma (PBL) is a clinically aggressive which has predilection for extranodal sites and frequently HIV-associated. The incidence of non-Hodgkin thought to be reduced by widescale antiretroviral therapy (ART) coverage, but the literature sparse as regards impact ART on PBL its outcomes in South Africa (SA). This study aimed compare factors interest cases diagnosed before after widespread availability Johannesburg, SA.All state sector hospitals Johannesburg 2007 2017 (before...
Introduction Extended differential parameters (EDPs) are generated with the automated count by Sysmex XN-series hematology analysers, and include immature granulocyte (IG%), neutrophil fluorescent light intensity (NE-SFL) distribution width (NE-WY). These have been proposed as early biomarkers of bacteremia. This study aimed to evaluate NE-SFL, NE-WY IG% in comparison CD64 (nCD64) expression (as a high quality sepsis biomarker) among patients suspected bacterial at Chris Hani Baragwanath...
Introduction Diffuse large B-cell lymphoma (DLBCL) is an aggressive malignancy of B-cells frequently encountered among people living with HIV. Immunological abnormalities are common in immunocompetent individuals DLBCL, and often associated poorer outcomes. Currently, data on derangements immunological proteins, such as cytokines acute phase reactants, their impact outcomes HIV-associated DLBCL (HIV-DLBCL) lacking. This study assessed the levels prognostic relevance interleukin (IL)-6, IL-10...
Background. The HIV epidemic in South Africa (SA) has had a substantial impact on laboratory services, at least partially owing to the well-described propensity cytopenias HIV-positive patients. Objectives. ( i ) To formally gauge of infection state sector haematology services SA by determining seropositivity rate among full blood counts (FBCs) performed large academic laboratory; and ii document prevalence patients this setting. Methods. Randomly selected FBCs submitted National Health...
Hepatosplenic T-cell lymphoma (HSTCL) is a rare type of Non-Hodgkin Lymphoma (NHL), grouped under the mature or peripheral lymphomas. It characterised by extranodal infiltration and proliferation malignant T-cells within sinusoids liver, sinuses red pulp spleen, bone marrow. The tumour cells express CD2 CD3, but are CD4, CD5 CD8 negative clonally restricted gamma-delta (or less commonly alpha-beta) receptor. disease has an aggressive clinical course associated with poor prognosis. We...
Anaemia is defined as a condition in which the number of red cells or their oxygen-carrying capacity insufficient to meet physiological needs. It most common disorder globally and one conditions that general practitioners frequently encounter. In World Health Organization global database, anaemia estimated affect 1.6 billion people. As manifests wide range conditions, it important embrace structured diagnostic approach. The recommended approach set out this article incorporates clinical...
Introduction Diffuse large B-cell lymphoma (DLBCL) is a high grade non-Hodgkin which common among immunodeficient people. Derangements of peripheral blood immune cells have been described to prognostic impact in DLBCL income countries, including monocytosis, the ratios lymphocytes both monocytes (L:M) and neutrophils (N:L), as well numbers regulatory T-cells (Tregs) immunosuppressive (HLA-DR low monos). To date, these variables has not assessed setting HIV-associated (HIV-DLBCL), most...
To address inborn errors of immunity (IEI) which were underdiagnosed in resource-limited regions, our centre developed and offered free genetic testing for the most common IEI by Sanger sequencing (SS) since 2001. With establishment The Asian Primary Immunodeficiency (APID) Network 2009, awareness definitive diagnosis further improved with collaboration among centres caring patients from East Southeast Asia. We also started to use whole exome (WES) undiagnosed cases extended South Asia...
Causes of thrombocytopenia range from laboratory errors to life-threatening pathological conditions. To establish the cause, appropriate investigation is required.To determine prevalence and causes platelet counts <100 × 10(9)/L in state health facilities Johannesburg, South Africa, as well quality subsequent work-up this setting.Full blood (FBCs) performed on 7 randomly selected days at National Health Laboratory Service Chris Hani Baragwanath Academic Hospital were retrospectively...
Background: The incidence of HIV-associated Hodgkin lymphoma (HIV-HL) has not dropped in the era widespread antiretroviral therapy (ART), and there have reportedly been shifts most prevalent variants encountered. In this study, factors interest cases HIV-HL diagnosed before after availability ART Johannesburg, South Africa, were compared. Methods: All 2007 2017 extracted from laboratory information system, pertinent Results: number HL increased significantly over period assessed, but without...
South Africa has a high HIV prevalence, which associates with an increased risk of lymphoma. Antiretroviral therapy (ART) became accessible in 2004, but the program substantially expanded. Changes lymphoma patterns are documented high-income countries after wide-scale ART including declining high-grade B-cell non-Hodgkin lymphomas (HG B-NHLs), particularly diffuse large lymphoma, and Hodgkin (HL). There limited data from Africa. This study aimed to compare HG B-NHL characteristics early...
Thrombocytopenia is common in HIV-infected individuals and often requires a diagnostic bone marrow examination. Interpretation may, however, be limited due to the multifactorial nature of HIV-associated thrombocytopenia difficulty assessing megakaryocyte function morphologically. The immature platelet fraction (IPF) parameter which reportedly reflects activity, with an IPF >7.7% suggesting increased production. aim this study was correlate findings as well other clinical variables interest...
Acute erythroid leukemia is rare, with isolated reports on presentation as an extramedullary tumor mass (myeloid sarcoma). We describe a case of pure presenting orbital in 1-year, 9-month-old girl. This only the second described child. Tissue biopsy showed medium-sized cells that were glycophorin A positive and negative conventional myeloid markers. Flow cytometry, bone marrow aspirate, trephine confirmed diagnosis leukemia.
Anaemia is defined as a condition in which the number of red cells or their oxygen-carrying capacity insufficient to meet physiological needs. It most common disorder globally and one conditions that general practitioners frequently encounter. In World Health Organization global database, anaemia estimated affect 1.6 billion people. As manifests wide range conditions, it important embrace structured diagnostic approach. The recommended approach set out this article incorporates clinical...
Diffuse large B-cell lymphoma (DLBCL) is a high-grade non-Hodgkin with increased incidence among people living HIV-infection (PLWH). Although its frequency reportedly attenuated by antiretroviral therapy (ART), we have previously shown similar rate of DLBCL in the post-ART era (2017) Johannesburg, South Africa compared that observed when ART had only limited availability state-sector (2007). Here, present more detailed analysis pre-and eras Johannesburg.All cases diagnosed hospitals...
Tuberculosis (TB) remains a global health problem. According to the 2013 Global Report on Tuberculosis, 8.6 million people developed TB in 2012 and 1.3 died from disease. An estimated 13% of who were HIV-positive, 75% these lived Africa. While pulmonary is commonest form Mycobacterium tuberculosis infection, extrapulmonary increasingly being detected HIV-positive patients. Definitive diagnosis disseminated challenge owing atypical presentations diagnostic difficulties (negative chest...
Bleeding disorders are divided into two broad categories, i.e. inherited, discussed in part 1 of this CME series, and acquired, which is the subject discussion current issue. In contrast to inherited haemorrhagic disorders, where generally a single haemostatic abnormality found, multiple defects commonly present acquired diseases. often presenting manifestation systemic disease requires multidisciplinary team approach. Iatrogenic causes abnormal haemostasis particular importance emergency...
Introduction: Primary plasma cell leukaemia is a rare and highly aggressive disease that commonly diagnosed decade earlier than multiple myeloma, at median age of 55 years. However, it has also been described in younger patients, as documented this case report. It often presents with hepatosplenomegaly lymphadenopathy, whilst the presence bony lesions are less-commonly seen when compared to myeloma.Case presentation: This report describes young woman who presented symptoms anaemia history...
Chronic myeloid leukaemia (CML) is a haematological malignancy characterised by the translocation t(9;22)(q34;q11.2), resulting in constitutively active tyrosine kinase. Globally, overall survival of blast crisis phase (BC) CML one year. Newer kinase inhibitors and allogeneic stem cell transplantation offer remission; however, refractory relapsed disease remain biggest challenges.In South Africa, literature lacking on BC-CML. This study aimed to determine characteristics Africa.This...