A5114239836- Viral-associated cancers and disorders
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- CNS Lymphoma Diagnosis and Treatment
- Histiocytic Disorders and Treatments
- Acute Lymphoblastic Leukemia research
- T-cell and B-cell Immunology
- Eosinophilic Disorders and Syndromes
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Global Cancer Incidence and Screening
- Pneumocystis jirovecii pneumonia detection and treatment
- Iron Metabolism and Disorders
- Parvovirus B19 Infection Studies
- Immune Cell Function and Interaction
- Multiple Myeloma Research and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Autoimmune Neurological Disorders and Treatments
- Cardiac Valve Diseases and Treatments
- vaccines and immunoinformatics approaches
- COVID-19 and healthcare impacts
- Animal Disease Management and Epidemiology
- Lymphadenopathy Diagnosis and Analysis
- Bone and Joint Diseases
- Vector-Borne Animal Diseases
University of the Witwatersrand
2002-2025
Chris Hani Baragwanath Hospital
2002-2025
Johannesburg Hospital
2015
United States Public Health Service
2015
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reverse transcriptase polymerase chain reaction (RT-PCR) cycle threshold (Ct) values serve as surrogate markers for estimating viral load. Their usefulness in patients with haematological malignancies and COVID-19 has not been studied the South African context.Objectives: To evaluate if a Ct value 30 can predict symptom development adult malignancies.Method: A retrospective cohort study on was conducted at Chris Hani...
Hodgkin's lymphoma (HL) occurs with increasing frequency in human-immunodeficiency-virus-(HIV-) infected individuals. The natural history and behaviour of HIV-HL is different, being more atypical aggressive. association between HIV HL appears to be primarily EBV driven. HAART use does not significantly impact on the incidence HL. Indeed, risk has increased post-HAART era. However, advent brought renewed hope, allowing standard therapeutic options used optimally, better treatment outcomes....
Human immunodeficiency virus (HIV) infection is endemic in South Africa. Non-Hodgkin lymphoma (NHL) occurs with increased frequency HIV seropositive individuals. The increase NHL has been more marked the last decade, being major contributor to this increase. More than 70% of adult patients at Chris Hani Baragwanath Academic Hospital (CHBAH), Soweto, Johannesburg, are seropositive. In addition, impacted on clinical presentation—being aggressive and atypical. Histologically, HIV-NHL typically...
Key Clinical Message Intracranial Hodgkin lymphoma ( HL ) is considered so atypical that an intracranial space‐occupying lesion in a patient with known should be thoroughly investigated to rule out second disease process.
Hepatosplenic T-cell lymphoma (HSTCL) is a rare type of Non-Hodgkin Lymphoma (NHL), grouped under the mature or peripheral lymphomas. It characterised by extranodal infiltration and proliferation malignant T-cells within sinusoids liver, sinuses red pulp spleen, bone marrow. The tumour cells express CD2 CD3, but are CD4, CD5 CD8 negative clonally restricted gamma-delta (or less commonly alpha-beta) receptor. disease has an aggressive clinical course associated with poor prognosis. We...
Diagnosis of AIDS lymphoma in low-resource settings, like South Africa, is often delayed, leaving patients with limited treatment options. In tuberculosis (TB) endemic regions, overlapping signs and symptoms lead to diagnostic delays. Assessment plasma cell-free DNA (cfDNA) by next-generation sequencing (NGS) may expedite the diagnosis but requires high-quality cfDNA.People living HIV newly diagnosed aggressive B-cell those TB seeking care at Chris Hani Baragwanath Academic Hospital its...
While the exact aetiology of myeloma is unknown, genetic factors feature among potential risk factors. The HLA phenotypes in African blacks with (the commonest haematopoietic malignancy this group) have not been characterized. purpose study was to determine class I and II patients multiple compare findings an ethnically matched control group 100 individuals. Analysis 62 revealed: (i) a corresponding statistically significant association B18 [odds ratio (OR) 6.3; 95% confidence interval (CI)...
Objective: Fine needle aspiration (FNA) is an early step in the work-up of lymphadenopathy people living with HIV (PLWH). We set out to characterize FNA cytology PLWH and report on time lymphoma diagnosis through clinics public healthcare system Johannesburg, South Africa. Design: Retrospective review laboratory database Methods: A retrospective chart patients undergoing department cytopathology at National Health Laboratory Service (NHLS) was undertaken. Results FNAs performed between March...
The uterine cervix and vaginal regions are infrequently infiltrated by lymphoma. Involvement of these topographic may constitute primary disease or more commonly represent a manifestation systemic lymphomatous disease. Herein, we report an expanded spectrum high-grade B-cell non-Hodgkin lymphomas comprising plasmablastic lymphoma (with without plasmacytic differentiation), ALK-positive large lymphoma, diffuse which involved the and/or vagina 6 patients at initial diagnosis. These tumors...
We utilised chromogenic and fluorescence in-situ hybridisation (CISH FISH) to evaluate MYC gene copy numbers rearrangements within HIV-associated plasmablastic lymphomas (PBLs). Thereafter, clinicopathological features were explored retrospectively.Sixty-seven (n = 67) patients included the HIV seropositive status was confirmed in 98% (63 of 64) with a median viral load 55 587 (IQR 273 582) copies/ml CD4 count 170 249) cells/µl. The mean age 41 ± 10.1 years females comprised 54%. PBL...
Abstract Background There is a great geographic variation of extranodal natural killer (NK)/T-cell lymphoma, nasal type (NNKTL) prevalence, with much higher prevalence in the Asian and South American populations. According to our knowledge searches, only one other case report/study NNKTL has been published Africa. Case presentation We present southern-African 31-year-old male residing township south Johannesburg, He presented signs symptoms similar those benign upper airway diseases. Further...
Acute adult T-cell leukaemia (AATL) is a clinical subtype of leukaemia/lymphoma, rare type peripheral T cell lymphoma. It associated with infection by the retrovirus Human T-Lymphotropic Virus Type-1 (HTLV-1), and seen most commonly in HTLV-1 endemic areas. The tumour cells have polylobulated nuclei morphologically are CD3+, CD4+ or CD8+, CD7-, express receptor , CD25+. disease has an aggressive course marked immunosuppression caused HTLV-1, poor prognosis. We report case young male patient...
Background: Acute Promyelocytic Leukaemia (APL) is a subtype of Myeloid (AML). APL medical emergency due to its high early mortality rate, most commonly bleeding complications resulting from an associated coagulopathy. However, eminently treatable. Aim: The aim the study was review clinical profile as well outcome adult patients presenting with APL, tertiary, public sector hospital (Chris Hani Baragwanath Academic Hospital -CHBAH) in Soweto, Johannesburg, South Africa. Patients and Methods:...