Abstract Plasmablastic lymphoma (PBL) is an aggressive B-cell non-Hodgkin associated with immunodeficiency in the context of human virus (HIV) infection or iatrogenic immunosuppression. While a rare disease general, incidence dramatically increased regions world high HIV prevalence. The molecular pathogenesis this poorly characterized. Here, we defined genomic features PBL cohort 110 patients from South Africa (15 by whole-exome sequencing and 95 deep targeted sequencing). We identified...

Background: HIV infection has been associated with an increased risk of non-Hodgkin lymphoma, particularly in the first world. Despite high burden sub-Saharan regions, published data on and malignancies are sparse from these areas. Materials Methods: We recently lymphomas diagnosed January 2004 to December 2006, at a single center Johannesburg, serve as baseline for long-term comparison during period highly active antiretroviral therapy rollout. report retrospective analysis follow-up...

HIV infection has been associated with an increased risk of malignancy, both AIDS defining and non-AIDS defining.This study presents a detailed pathological description newly diagnosed lymphomas in Johannesburg, South Africa (January 2004 December 2006). The review coincides introduction combination antiretroviral therapy.One thousand eight hundred ninety-seven new lymphoproliferative disorders were referred to the Charlotte Maxeke Johannesburg Academic Hospital. B-cell non-Hodgkin lymphoma...

Comparative data on the distribution of non-Hodgkin lymphoma (NHL) subtypes in Southern Africa (SAF) is scarce. In this study, five expert haematopathologists classified 487 consecutive cases NHL from SAF using World Health Organization classification, and compared results to North America (NA) Western Europe (WEU). had a significantly lower proportion low-grade (LG) B-NHL (34·3%) higher high-grade (HG) (51·5%) WEU (54·5% 36·4%) NA (56·1% 34·3%). High-grade Burkitt-like was more common...

Plasmablastic lymphoma (PBL) is an aggressive B-cell non-Hodgkin associated with immunodeficiency in the context of human virus (HIV) infection or iatrogenic immunosuppression. While a rare disease general, incidence dramatically increased regions world high HIV prevalence. The molecular pathogenesis this poorly characterized. Here, we defined genomic features PBL cohort 110 patients from South Africa (15 by whole-exome sequencing and 95 deep targeted sequencing). We identified recurrent...

Aims Plasmablastic lymphoma (PBL) occurs mainly in immunocompromised individuals, usually secondary to human immunodeficiency virus (HIV) infection. It classically intraorally, but has been described extraoral locations. The aim of this study was define the immunophenotype and Epstein–Barr (EBV) status a large single‐centre cohort PBL (EPBL) South Africa, high‐prevalence HIV setting. Methods results This retrospective 45 EPBLs included patients' age, gender, race, status, site. Cases were...

Abstract Microsatellite Instability (MSI) is a hallmark of colorectal cancer (CRC) and occurs in 15–16% CRC. Molecular biological information CRC South Africa (SA) largely unrecorded. This study was undertaken to determine the frequency MSI, with particular reference Lynch syndrome (LS) view improve surveillance prevention strategies. retrospective on samples diagnosed between 2011–2015 at Charlotte Maxeke Johannesburg Academic Hospital (CMJAH). Samples 2011–2012 were screened for MSI by PCR...

Background and Aim Epidemiological studies of colorectal cancer (CRC) in South Africa (SA) have been poorly characterized. Black white SA population groups demonstrated distinct CRC clinical presentations, suggesting that black patients follow a different carcinogenic pathway than their counterparts. Thus, the aim this study was to identify unique demographic histopathological features associated with facilitate earlier diagnosis improve disease management. Methods This preliminary...

Plasmablastic lymphoma (PBL) is a clinically aggressive which has predilection for extranodal sites and frequently HIV-associated. The incidence of non-Hodgkin thought to be reduced by widescale antiretroviral therapy (ART) coverage, but the literature sparse as regards impact ART on PBL its outcomes in South Africa (SA). This study aimed compare factors interest cases diagnosed before after widespread availability Johannesburg, SA.All state sector hospitals Johannesburg 2007 2017 (before...

This study aimed to compare the degree of epigenetic modifications between a TB-HIV co-infected cohort and uninfected subjects. Formalin-fixed paraffin-embedded (FFPE) tissues were retrieved from 45 control individuals. Real-time PCR was applied level expression genes involved in regulation. The protein multiplex assay used assess modification. DNA sequencing determine evolutionary relationships infecting HIV Mtb strains. Our results indicated significant increase five candidate patients...

Background: The incidence of HIV-associated Hodgkin lymphoma (HIV-HL) has not dropped in the era widespread antiretroviral therapy (ART), and there have reportedly been shifts most prevalent variants encountered. In this study, factors interest cases HIV-HL diagnosed before after availability ART Johannesburg, South Africa, were compared. Methods: All 2007 2017 extracted from laboratory information system, pertinent Results: number HL increased significantly over period assessed, but without...

South Africa has a high HIV prevalence, which associates with an increased risk of lymphoma. Antiretroviral therapy (ART) became accessible in 2004, but the program substantially expanded. Changes lymphoma patterns are documented high-income countries after wide-scale ART including declining high-grade B-cell non-Hodgkin lymphomas (HG B-NHLs), particularly diffuse large lymphoma, and Hodgkin (HL). There limited data from Africa. This study aimed to compare HG B-NHL characteristics early...

We utilised chromogenic and fluorescence in-situ hybridisation (CISH FISH) to evaluate MYC gene copy numbers rearrangements within HIV-associated plasmablastic lymphomas (PBLs). Thereafter, clinicopathological features were explored retrospectively.Sixty-seven (n = 67) patients included the HIV seropositive status was confirmed in 98% (63 of 64) with a median viral load 55 587 (IQR 273 582) copies/ml CD4 count 170 249) cells/µl. The mean age 41 ± 10.1 years females comprised 54%. PBL...

Diffuse large B-cell lymphoma (DLBCL) is a high-grade non-Hodgkin with increased incidence among people living HIV-infection (PLWH). Although its frequency reportedly attenuated by antiretroviral therapy (ART), we have previously shown similar rate of DLBCL in the post-ART era (2017) Johannesburg, South Africa compared that observed when ART had only limited availability state-sector (2007). Here, present more detailed analysis pre-and eras Johannesburg.All cases diagnosed hospitals...

Abstract A 45‐year‐old black patient presented with right‐heart failure. Echocardiography showed a large tumor mass in the right atrium and debulking procedure was performed. Histological immunohistochemical studies revealed high grade angiosarcoma infiltrating myocardium extending to pericardial surface. Metastatic work‐up no evidence of dissemination. The made an uneventful postsurgical recovery treated chemotherapy, consisting epidoxorubicin dacarbazin. Following echocardiographic...

Abstract Endemic Burkitt lymphoma (eBL) is an aggressive B cell cancer characterized by IgH/c-myc translocation and the harboring of Epstein–Barr virus (EBV). Evidence accumulates that CD4 + T cells might contribute to eBL pathogenesis. Here, we investigate presence in primary tissue their potential dichotomous impact on EBV-infected pre-eBL model using ex vivo material vitro co-cultures. In addition, establish a novel method study effect employing CRISPR/Cas9 knock-in approach introduce tag...

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Originally described exclusively orally in HIV-infected patients, plasmablastic lymphoma (PBL) is increasingly extra and non-HIV-infected persons. The study comparatively analysed the clinico-pathologic features of oral PBLs (n = 55) to previously published extra-oral 45 + 1) diagnosed over a seven-year period at same institution an HIV prevalent setting South Africa order clarify any distinction between PBLs.Tumours were assessed histologically immunohistochemically with CD45 (LCA), CD3,...

Abstract Background There is a great geographic variation of extranodal natural killer (NK)/T-cell lymphoma, nasal type (NNKTL) prevalence, with much higher prevalence in the Asian and South American populations. According to our knowledge searches, only one other case report/study NNKTL has been published Africa. Case presentation We present southern-African 31-year-old male residing township south Johannesburg, He presented signs symptoms similar those benign upper airway diseases. Further...

A large proportion of indigenous African (IA) colorectal cancer (CRC) patients in South Africa are young (< 50 years), with no unique histopathological or molecular characteristics. Anatomical site as well microsatellite instability (MSI) status have shown to be associated different clinicopathological and features. This study aimed ascertain key features stable (MSS) low-frequency MSI (MSI-L) patients, provide insight into the mechanism disease.A retrospective cohort (2011-2015) MSS/MSI-L...

CITATION: Ayers, L.W. et al. 2012. HIV/AIDS-related non-Hodgkin’s lymphomas and confounders : preliminary report of the Sub-Saharan Africa Lymphoma Consortium (SSALC). Infectious Agents Cancer, 7(Suppl 1):P11, doi:10.1186/1750-9378-7-S1-P11.