A5111416012- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- CNS Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Histiocytic Disorders and Treatments
- Eosinophilic Disorders and Syndromes
- Pneumocystis jirovecii pneumonia detection and treatment
- Chronic Myeloid Leukemia Treatments
- Parvovirus B19 Infection Studies
- Autoimmune Neurological Disorders and Treatments
- Vector-Borne Animal Diseases
- T-cell and Retrovirus Studies
- Prenatal Screening and Diagnostics
- Hemoglobinopathies and Related Disorders
- Global Cancer Incidence and Screening
- Iron Metabolism and Disorders
- Glioma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Multiple Myeloma Research and Treatments
- Cardiac tumors and thrombi
- Animal Disease Management and Epidemiology
- Polyomavirus and related diseases
- Diagnosis and treatment of tuberculosis
- Immune Cell Function and Interaction
University of the Witwatersrand
2012-2024
Chris Hani Baragwanath Hospital
2012-2024
Johannesburg Hospital
2015
United States Public Health Service
2015
Background: Autologous stem cell transplantation (ASCT) is the standard of care for multiple myeloma (MM), even in era novel therapeutic agents. Data regarding ASCT outcomes MM lacking South Africa.Aim: To assess impact on at a public health facility.Setting: Clinical Haematology Unit, Chris Hani Baragwanath Academic Hospital, Johannesburg.Methods: A retrospective analysis patients who received over 19 years.Results: Fifty-one as part their treatment schedule. While 41 single...
Human immunodeficiency virus (HIV) infection is endemic in South Africa. Non-Hodgkin lymphoma (NHL) occurs with increased frequency HIV seropositive individuals. The increase NHL has been more marked the last decade, being major contributor to this increase. More than 70% of adult patients at Chris Hani Baragwanath Academic Hospital (CHBAH), Soweto, Johannesburg, are seropositive. In addition, impacted on clinical presentation—being aggressive and atypical. Histologically, HIV-NHL typically...
Key Clinical Message Intracranial Hodgkin lymphoma ( HL ) is considered so atypical that an intracranial space‐occupying lesion in a patient with known should be thoroughly investigated to rule out second disease process.
Hepatosplenic T-cell lymphoma (HSTCL) is a rare type of Non-Hodgkin Lymphoma (NHL), grouped under the mature or peripheral lymphomas. It characterised by extranodal infiltration and proliferation malignant T-cells within sinusoids liver, sinuses red pulp spleen, bone marrow. The tumour cells express CD2 CD3, but are CD4, CD5 CD8 negative clonally restricted gamma-delta (or less commonly alpha-beta) receptor. disease has an aggressive clinical course associated with poor prognosis. We...
Diagnosis of AIDS lymphoma in low-resource settings, like South Africa, is often delayed, leaving patients with limited treatment options. In tuberculosis (TB) endemic regions, overlapping signs and symptoms lead to diagnostic delays. Assessment plasma cell-free DNA (cfDNA) by next-generation sequencing (NGS) may expedite the diagnosis but requires high-quality cfDNA.People living HIV newly diagnosed aggressive B-cell those TB seeking care at Chris Hani Baragwanath Academic Hospital its...
The uterine cervix and vaginal regions are infrequently infiltrated by lymphoma. Involvement of these topographic may constitute primary disease or more commonly represent a manifestation systemic lymphomatous disease. Herein, we report an expanded spectrum high-grade B-cell non-Hodgkin lymphomas comprising plasmablastic lymphoma (with without plasmacytic differentiation), ALK-positive large lymphoma, diffuse which involved the and/or vagina 6 patients at initial diagnosis. These tumors...
<p>Hypereosinophilia is a rare paraneoplastic nding in malignant disease, particularly lung cancer. When it occurs, usually indicative of<br />metastatic disease. We describe 52-year-old male patient with hypereosinophilia associated primary adenocarcinoma<br />of the right lower lobe and extensive metastatic disease.</p>
We utilised chromogenic and fluorescence in-situ hybridisation (CISH FISH) to evaluate MYC gene copy numbers rearrangements within HIV-associated plasmablastic lymphomas (PBLs). Thereafter, clinicopathological features were explored retrospectively.Sixty-seven (n = 67) patients included the HIV seropositive status was confirmed in 98% (63 of 64) with a median viral load 55 587 (IQR 273 582) copies/ml CD4 count 170 249) cells/µl. The mean age 41 ± 10.1 years females comprised 54%. PBL...
Abstract Background There is a great geographic variation of extranodal natural killer (NK)/T-cell lymphoma, nasal type (NNKTL) prevalence, with much higher prevalence in the Asian and South American populations. According to our knowledge searches, only one other case report/study NNKTL has been published Africa. Case presentation We present southern-African 31-year-old male residing township south Johannesburg, He presented signs symptoms similar those benign upper airway diseases. Further...
Acute adult T-cell leukaemia (AATL) is a clinical subtype of leukaemia/lymphoma, rare type peripheral T cell lymphoma. It associated with infection by the retrovirus Human T-Lymphotropic Virus Type-1 (HTLV-1), and seen most commonly in HTLV-1 endemic areas. The tumour cells have polylobulated nuclei morphologically are CD3+, CD4+ or CD8+, CD7-, express receptor , CD25+. disease has an aggressive course marked immunosuppression caused HTLV-1, poor prognosis. We report case young male patient...